Antibiotics acting as neuroprotectants via mechanisms independent of their anti-infective activities

Stock, Michelle L.; Fiedler, Kara J.; Acharya, Sreemoyee; Lange, Jennifer K.; Mlynarczyk, Gregory S.A.; Anderson, Stephen J.; McCormack, Garrett R.; Kanuri, Sri Harsha; Kondru, Naveen; Brewer, Matthew T.; Carlson, Steve A.

doi:10.1016/j.neuropharm.2013.04.059

Cited by 18 publications

(19 citation statements)

References 146 publications

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“…Minocycline, a tetracycline antibiotic, shows antiinflammatory neuroprotective effects independent of its anti-microbial activity 14 . It offers advantages as a candidate for treatment for stroke because of its superior penetration of the brain tissue prolonged treatment window and good chemical safety 14,15 .…”

Section: Mcpip In Pharmacological Preconditioningmentioning

confidence: 99%

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MCPIP mediates preconditioning protection against ischemia

Kolattukudy¹

2016

J Neurol Neuromedicine

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Inflammatory response represents one of the first immune processes following injury. However, evidence indicates that inflammatory response can also induce cellular protection associated in with preconditioning, a phenomenon in which brief episodes of a sublethal insult induce robust protection against subsequent lethal injuries. The elucidation of mechanisms that allow inflammatory response to confer cellular protection is critical to developing new therapeutic strategies against acute ischemic insults. In the present review, we will give a short overview on a novel zinc-finger protein, MCPIP (also known as Zc3h12a or Regnase-1), which may function as a master integrator of endogenous cellular protection exerted by preconditioning.

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Section: Mcpip In Pharmacological Preconditioningmentioning

confidence: 99%

“…It offers advantages as a candidate for treatment for stroke because of its superior penetration of the brain tissue prolonged treatment window and good chemical safety 14,15 . The neuroprotective effect of minocycline against ischemic stroke is mediated via MCPIP 16 .…”

Section: Mcpip In Pharmacological Preconditioningmentioning

confidence: 99%

MCPIP mediates preconditioning protection against ischemia

Kolattukudy¹

2016

J Neurol Neuromedicine

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“…Therapy with this Salmonella would optimally include a beta-lactam antibiotic or a beta-lactamase inhibitor [22] plus minocycline. Therapy with this Salmonella would optimally include a beta-lactam antibiotic or a beta-lactamase inhibitor [22] plus minocycline.…”

Section: Salmonella and Brain Cancermentioning

confidence: 99%

Salmonella as a biological “Trojan horse” for neoplasia: Future possibilities including brain cancer

et al. 2014

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“…Studies concerning minocycline (a derivative of tetracycline; 7-dimethylamino-6-dimethyl-6-deoxytetracycline) indicate that the antibiotic has multi-faced effects on cell functions and consequently a number of clinical properties that are useful and/or could be useful for treatment of different diseases, including bacterial infections, cancer, autoimmune disorders, ischemia as well as neurodegenerative and psychiatric diseases (for review, see for example, Garrido-Mesa et al, 2013, Karachitos et al 2013, Stock et al, 2013and Fond et al, 2014. Accordingly, it is becoming evident that minocycline-mediated cytoprotection is an important aspect of its clinical application.…”

Section: Introductionmentioning

confidence: 99%