Antibiotic Utilization Pattern at the Surgery Department of a Tertiary Care Hospital

Abstract

Objective: This study aims to determine the pattern of antibiotic utilization at the surgery department of a tertiary care hospital.Methods: A prospective observational study was conducted over a period of 6-month in surgical ward at Bharti Hospital and Research Centre, Pune, a 1000 bedded teaching hospital. Patients above 18 years and receiving antibiotic therapy pre-and post-surgery were included in the study.Results: A total of 160 patients with surgical operations were included in the study. The disease spectrum was classified into respective system-wise surgical procedures of which 49.37% cases are skin and soft tissue infections, 25.62% cases of general surgical procedure, 12.5% cases of gastrointestinal surgical procedure, 11.25% cases of urinary system, and 1.25% case of head-neck system. 20.62% of the study patients had hernia, 18.12% patients had cellulitis, 16.87% patients had diabetic foot ulcer, 16.25% patients had abscess, and 10.62% patients had appendicitis and cholelithiasis. In this study, it was found that 471 antibiotics were used in total of 160 patients, among which highest group of antibiotics prescribed were third generation cephalosporin (28.23%) followed by penicillins (23.56%). The most frequently prescribed antibiotics were metronidazole -19.74% among the nitroimidazoles followed by ceftriaxone -19.53% of the class cephalosporins. Conclusion:The rate of prescribing of broad-spectrum antibiotics has increased demonstrably which may result in the development of bacterial resistance; however, development of guidelines for an antibiotic prescription and use of appropriate drugs for the diseases can minimize the unfavorable use of antibiotics and cost of health care.

Surgical Site Infection Related Risk Factors and Usage of Antibiotics in Two Different Tertiary Care Hospitals of Dhaka City, Bangladesh

“…In this current study, 31.4% of cases came from the age group 40-49 years. A similar study conducted in Pune, India, had 32.5% operative patients lying under the age group 34-49 years [10], whereas the majority of the surgical patients were between the ages 18-40 years which were found in a separate study of India [11].…”

“…The most commonly prescribed antibiotics were ceftriaxone (38%) as reported by Joshi et al [11]. Besides, top postoperative antibiotics prescribed were metronidazole, cefotaxime, and ceftriaxone which were found in two different studies in India [6,10]. Amoxicillin (26%) was discovered as a drug of choice, followed by penicillin (20%) [14], whereas the most common antimicrobial agents used were cefotaxime (81%), followed by cefoperazone sodium (42%), ceftriaxone (25%), and amoxicillin with clavulanate (20%) in surgical patients [17].…”

A Study of Antibacterial Utilization Pattern in a Tertiary Care Hospital

“…In most of the studies, general medicine department prescribed the highest number of antimicrobials as infectious cases will be admitted to this department [8,9,13]. Carrying out study in various departments will add to the advantage of getting a better picture of utilization pattern of antibacterials by different medical specialists.…”

Assessment of Antibiotic Utilization Pattern In Hospital Settings

“…Cephalosporin class of antibiotics is seen to be the most frequently prescribed antibiotic due to its relatively broader spectrum of activity and lower toxicity for several infections. Among cephalosporin class of antibiotics, ceftriaxone is the most frequently prescribed followed by other classes of antibiotics like penicillins, nitroimidazoles and luoroquinolones (Raut et al, 2017). In most of the scenarios, the category of use of antibiotic is seen as prophylaxis.…”