Antibiotic use and the development of depression: A systematic review

Pouranayatihosseinabad, Mahsa; Bezabih, Yihienew; Hawrelak, Jason; Peterson, Gregory M.; Veal, Felicity; Mirkazemi, Corinne

doi:10.1016/j.jpsychores.2022.111113

Cited by 10 publications

(10 citation statements)

References 72 publications

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“… 4 , 5 , 6 A recent systematic review indicated the association between antibiotics use and subsequent development of depression. 7 This is largely because antibiotics reduce the diversity of gut microbiota. 8 Moreover, an unhealthy diet and environmental exposures that influence the gut microbial composition were proved to be highly associated with the increased incidence of depression in recent years.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota and its metabolites in depression: from pathogenesis to treatment

Liu¹,

Wang²,

Chen³

et al. 2023

eBioMedicine

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Section: Introductionmentioning

confidence: 99%

Gut microbiota and its metabolites in depression: from pathogenesis to treatment

Liu¹,

Wang²,

Chen³

et al. 2023

eBioMedicine

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“…Furthermore, there is an increased risk of severe mental illnesses after antibiotic use, which reduces the gut microbiota diversity, 121–123 including a direct association between antibiotics use and subsequent development of depression. 124 Similarly, exposure to environmental factors or unhealthy diet known to impact the microbiome increases the incidence of depression. 125 , 126 Although modulation of the microbiota affects both cognition and mood, 106 , 116 , 127–132 the mechanisms whereby the gut microbiota promotes depression remains to be fully understood.…”

Section: Stressmentioning

confidence: 99%

Stress in the microbiome-immune crosstalk

Beurel

2024

Gut Microbes

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The gut microbiota exerts a mutualistic interaction with the host in a fragile ecosystem and the host intestinal, neural, and immune cells. Perturbations of the gastrointestinal track composition after stress have profound consequences on the central nervous system and the immune system. Reciprocally, brain signals after stress affect the gut microbiota highlighting the bidirectional communication between the brain and the gut. Here, we focus on the potential role of inflammation in mediating stress-induced gut-brain changes and discuss the impact of several immune cells and inflammatory molecules of the gut-brain dialogue after stress. Understanding the impact of microbial changes on the immune system after stress might provide new avenues for therapy.

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“…A recent systematic review of the relationship between antibiotic use and the development of depression in humans revealed an increased risk of depression following antibiotic use (Pouranayatihosseinabad et al, 2023). The review of over 1 million participants confirmed that the risk of depression increases by over 20% following antibiotic use.…”

Section: Mdd and The Mgbamentioning

confidence: 99%

“…The review of over 1 million participants confirmed that the risk of depression increases by over 20% following antibiotic use. Moreover, a greater number of antibiotic courses was associated with a greater risk of depression and the risk declined over the ensuing 10 years after exposure (Pouranayatihosseinabad et al, 2023).…”

Section: Mdd and The Mgbamentioning

confidence: 99%

Just a gut feeling: Faecal microbiota transplant for treatment of depression – A mini-review

Chang,

Chang

2024

J Psychopharmacol

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Background: The microbiota–gut–brain axis (MGBA) allows bidirectional crosstalk between the brain and gut microbiota (GM) and is believed to contribute to regulating mood/cognition/behaviour/metabolism/health and homeostasis. Manipulation of GM through faecal microbiota transplant (FMT) is a new, exciting and promising treatment for major depressive disorder (MDD). Aims: This mini-review examines current research into GM and FMT as a therapy for depression. Methods: Original research articles published in Medline/Cochrane Library/PubMed/EMBASE/PsycINFO databases/National Institute of Health website Clinicaltrials.gov/controlled-trials.com were searched. Full articles included in reference lists were evaluated. We summarise current data on GM and depression and discuss communication through the MGBA and the interaction of antidepressants and GM through this. We review compositions of dysbiosis in depressed cohorts, focusing on future directions in the treatment of MDD. Results: Studies have demonstrated significant gut dysbiosis in depressed patients compared to healthy cohorts, with overgrowth of pro-inflammatory microbiota, reduction in anti-inflammatory species and reduced overall stability and taxonomic richness. FMT allows the introduction of healthy microbiota into the gastrointestinal tract, facilitating the restoration of eubiosis. Conclusion: The GM plays an integral role in human health and disease through its communication with the rest of the body via the MGBA. FMT may provide a means to transfer the healthy phenotype into the recipient and this concept in humans is attracting enormous attention as a prospective treatment for psychopathologies, such as MDD, in the future. It may be possible to manipulate the GM in a number of ways, but further research is needed to determine the exact likelihood and profiles involved in the development and amelioration of MDD in humans, as well as the long-term effects and potential risks of this procedure.

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Antibiotic use and the development of depression: A systematic review

Cited by 10 publications

References 72 publications

Gut microbiota and its metabolites in depression: from pathogenesis to treatment

Gut microbiota and its metabolites in depression: from pathogenesis to treatment

Stress in the microbiome-immune crosstalk

Just a gut feeling: Faecal microbiota transplant for treatment of depression – A mini-review

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