Antibiotic use and inflammatory bowel diseases in childhood

Hviid, Anders; Svanström, Henrik; Frisch, Mørten

doi:10.1136/gut.2010.219683

Cited by 429 publications

(307 citation statements)

References 18 publications

(17 reference statements)

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“…Metagenomic studies provide a profile of the microbial communities in the human gut and reveal an association between low microbial diversity and several disease states, including IBD, metabolic disorders and IBS. [30][31][32][33][34][35][36] Even if a cause-effect relationship between low microbial richness and disease has not been established, it is known that exposure to antibiotics early in life is a risk factor for the development of IBD 37 or obesity, 38 sug gesting that depletion of some critical commensals might have health consequences later in life. These observations, among others, support the hypothesis that the increasingly vulnerable human microbiota and specifically defective colonization by 'old friends' play a part in the aetiology of a number of disorders of modern society.…”

Section: Should the Probiotic Framework Include Well-defined Beneficimentioning

confidence: 99%

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Hill

Guarner

Reid

et al. 2014

Nat Rev Gastroenterol Hepatol

6,156

3,637

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| An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics. It is now 13 years since the definition of probiotics and 12 years after guidelines were published for regulators, scientists and industry by the Food and Agriculture Organization of the United Nations and the WHO (FAO/WHO). The FAO/WHO definition of a probiotic-"live microorganisms which when administered in adequate amounts confer a health benefit on the host"-was reinforced as relevant and sufficiently accommodating for current and anticipated applications. However, inconsistencies between the FAO/WHO Expert Consultation Report and the FAO/WHO Guidelines were clarified to take into account advances in science and applications. A more precise use of the term 'probiotic' will be useful to guide clinicians and consumers in differentiating the diverse products on the market. This document represents the conclusions of the ISAPP consensus meeting on the appropriate use and scope of the term probiotic.

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Section: Should the Probiotic Framework Include Well-defined Beneficimentioning

confidence: 99%

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Hill

Guarner

Reid

et al. 2014

Nat Rev Gastroenterol Hepatol

6,156

3,637

View full text Add to dashboard Cite

show abstract

“…To normalize gut microbiota, rats from all groups were kept in the same room and maintained by the same personal. Study was approved by the bioethical committee of ESC "Institute of Biology" Taras Shevchenko National University of Kyiv (Protocol No 8 issued by Nov, 2,2015).…”

Section: Methodsmentioning

confidence: 99%

“…In 2011, two independent groups reported about positive correlation between longterm use of antibiotics and the risk of IBD in children [2] and adults (average age -43.4 years) [12]. The mechanisms underlying this phenomenon are hypothetical and require empirical study.…”

Section: Introductionmentioning

confidence: 99%

The disturbance of oxidant-antioxidant balance in rat colonic mucosa after antibiotic therapy

Holota¹,

Tjapko²,

Dovbynchuk³

et al. 2015

Biol. Stud.

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Antibiotic treatment increases susceptibility to development of inflammatory bowel diseases (IBD) both in children and adults. Oxidative stress plays a prominent role in IBD pathogenesis. The aim of present study was to test an interrelationship between the morphological changes in rat colonic mucosa, the levels of antioxidant enzymes and redox sensitive transcription factors Egr-1 and Sp-1 after treatment with cephalosporin antibiotic ceftriaxone (Cf) with broad spectrum of action. Study was performed on male Wistar rats (180-230 g). Cf (50 mg/kg, i.m.) were injected daily for 5 days. The colonic levels of catalase and superoxide dismutase activity were measured by the colorimetric assays and zymography; levels of Egr-1 and Sp-1 -by Western-blot analysis; histological chan ges -by morphometric analysis. Body weight and diarrhea were recorded. Systemic administration of the ceftriaxone induced morphological and functional changes in rat colonic mucosa associated with initial stages of the acute inflammation. These changes were accompanied by a decrease of activity of superoxide dismutase and catalase. Levels of redox-sensitive transcription factors Egr-1 and Sp1 were significantly increased, which shows a disturbance of homeostasis of the intestinal barrier.

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“…15 The relationship between the host-gut microbiota and systemic immunity attracting more and more attention, however, the mechanism for this phenomenon remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Dysbiosis of gut microbiota induced the disorder of helper T cells in influenza virus-infected mice

Dai

Chen³

et al. 2015

Human Vaccines & Immunotherapeutics

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Antibiotic use and inflammatory bowel diseases in childhood

Cited by 429 publications

References 18 publications

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

The disturbance of oxidant-antioxidant balance in rat colonic mucosa after antibiotic therapy

Dysbiosis of gut microbiota induced the disorder of helper T cells in influenza virus-infected mice

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