Antibiotic usage and the incidence of resistance

Huovinen, P

doi:10.1111/j.1469-0691.1999.tb00852.x

Cited by 10 publications

(12 citation statements)

References 24 publications

(30 reference statements)

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“…In itself, the observation that there is a direct relationship between antibiotic use and the frequency of resistance in different geographic areas [1][2][3][4][5][6] does not necessarily mean that reductions in antibiotic use will be reflected as declines in the frequencies of resistance. It could be that the rate of ascent of resistance in regions (countries) with lower rates of antibiotic consumption and currently lower frequencies of resistance is simply lower than that in regions where antibiotic consumption is greater.…”

Section: Population Biology Of Antibiotic Treatment and Resistance Inmentioning

confidence: 94%

“…It is also clear that the frequency of resistance in bacteria and the number of different antibiotics to which individual bacteria are resistant are directly related to the consumption of these agents and the patterns in which different agents are used [1][2][3][4][5][6]. Not so clear is whether we can substantially reduce the frequency of antibiotic resistance in bacteria by controlling the consumption of antibiotics and modifying the patterns of use of different antibiotics.…”

mentioning

confidence: 94%

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Minimizing Potential Resistance: A Population Dynamics View

2001

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I examine the results of studies that used mathematical models of the epidemiology and population genetics of antibiotic treatment and resistance in open communities and in hospitals to explore the following issues: the relationship between antibiotic consumption and the frequency of antibiotic resistance in bacterial populations in communities and in hospitals; methods of controlling the growth, dissemination, and persistence of antibiotic resistance in these settings; the extent to which resistance can be controlled; and the speed with which the effects of control measures will be realized. In open communities, it will take years or even decades to see substantial reductions in the frequency of antibiotic resistance solely as a result of more prudent (reduced) use of antibiotics. However, if we can restrict the input of resistant bacteria into hospitals, through the application of infection control and other measures, it should be possible to reduce the frequency of resistance and even eliminate resistant bacteria from these institutions in short order.

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Section: Population Biology Of Antibiotic Treatment and Resistance Inmentioning

confidence: 94%

mentioning

confidence: 94%

Minimizing Potential Resistance: A Population Dynamics View

2001

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“…Regarding resistance to erythromycin, there are well‐documented studies in streptococci, evaluating its relation to the consumption of macrolides, and about the decline in macrolide resistance following a decrease in macrolide usage [28,29]. In this study, however, the only macrolide prescribed was clarithromycin, in four cases.…”

Section: Comparative Antimicrobial Susceptibility Of S Pneumoniae Stmentioning

confidence: 81%

Molecular diagnosis of recurrent Streptococcus mutans endocarditis by PCR amplification and sequencing

Gauduchon

Bénito

Célard

et al. 2001

Clinical Microbiology and Infection

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“…However, in some countries, among them The Netherlands and Denmark, such resistance has not yet become a significant medical problem [18,19]. The development of antibacterial resistance is closely linked to consumption of antibacterials [2,13–15]. In Iceland, a decline in the prevalence of penicillin‐resistant S. pneumoniae was observed following a campaign aimed at reducing the prescription of antibacterials [20].…”

Section: Discussionmentioning

confidence: 99%

“…Increased bacterial resistance is associated with high antibiotic consumption [2,13–15]. In Norway, consumption of antibacterial agents is low, but little is known of bacterial susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women

Auquer

Cordón

Gorina

et al. 2002

Clinical Microbiology and Infection

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A double-blind, randomized controlled study to evaluate the efficacy and safety of a single dose of 500 mg of ciprofloxacin versus 3 days 400 mg twice-daily of norfloxacin in uncomplicated urinary tract infection in women was designed. Patients underwent four visits: baseline, and at 3, 7 and 28 days. The main efficacy variables were clinical and microbiological outcome at day 7. Analyses on both valid patients and intention-to-treat populations were performed. Two hundred and twenty-six patients (114 receiving ciprofloxacin and 112 receiving norfloxacin) were considered valid for efficacy evaluation. Bacteriologic cure was 91.2% in the ciprofloxacin group and 91.9% in the norfloxacin group. Clinical resolution was 91.2 and 93.8%, respectively. Both treatments were equally efficacious (P = 0.016).

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Antibiotic usage and the incidence of resistance

Cited by 10 publications

References 24 publications

Minimizing Potential Resistance: A Population Dynamics View

Minimizing Potential Resistance: A Population Dynamics View

Molecular diagnosis of recurrent Streptococcus mutans endocarditis by PCR amplification and sequencing

Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women

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