Antibiotic Susceptibility Profile of respiratory pathogens obtained at tertiary care hospital from western Nepal

Abstract

The prevalence and drug resistance of the respiratory pathogens is increasing gradually in Nepal. However, their detail study is rare in the western region of Nepal. Hence, this study was carried out to know the incidence and antibiotic susceptibility profile of the respiratory pathogens obtained at a tertiary care center located at Pokhara. 139 pathogens were isolated from 460 clinical samples included. Significant pathogens were Gram-negative bacteria 94 (67.62%), followed by 28 (20.15%) Candida, and Gram-positive isolates 17 (12.23%). The growth rate was significantly higher for sputum samples in comparison to throat swabs. Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter were significant Gram-negative isolates while Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes were Gram-positive pathogens. Sensitivity rate was higher for colistin and imipenem among Gram-negative isolates while lower sensitivity was for cefepime. Vancomycin was effective against all tested Gram-positive isolates while erythromycin and ciprofloxacin were less effective.

Positive Bacterial Culture among Lower Respiratory Tract Specimens of Patients in a Tertiary Care Centre: A Descriptive Cross-sectional Study

“…1 Another study was done in Nepal also shows cultural positivity of 30.2% with gram-negative predominance. 10 In this study, Klebsiella pneumoniae (37.9%) was the most common isolate followed by ACB complex (29.3%). The other isolates included Escherichia coli, Pseudomonas aeruginosa, Citrobacter species, Staphylococcus aureus.…”

“…This is in concordance with another study that reported that gram-negative bacteria have a higher sensitivity to carbapenems. 10 High rate of resistance of the gramnegative isolates was observed towards ampicillin, cephalosporins, cotrimoxazole, and levofloxacin. The gram-negative isolates were resistant to most of the antibiotics tested.…”

“…1 Another study was done in Nepal also shows cultural positivity of 30.2% with gram-negative predominance. 10 …”