Antibiotic Susceptibility Patterns of Bacteria Associated with Sepsis among Hospitalized Patients in the Yaound&amp;#233; University Teaching Hospital—Cameroon

Yimtchi, Lavoisier Christian Ngassa; Pokam, Benjamin D. Thumamo; Baiye, Abange William; Betbeui, Anicette Chafa; Gonsu, Hontense Kamga; Djakissam, Watching

doi:10.4236/ojmm.2023.131009

Cited by 1 publication

(4 citation statements)

References 18 publications

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“…This prevalence is higher than those reported in Africa [32][33][34]. The observed difference in this review may be due to the small sample size of many included studies [20,22,26,27] and their study design. The study revealed that Enterobacterales, including Escherichia coli (23.09%) and Klebsiella spp.…”

Section: Discussioncontrasting

confidence: 62%

“…However, studies conducted in Ethiopia by Bitew et al (2023), Legese et al (2022) and Abebe et al (2021) documented a similar prevalence of BSI [32–34]. The observed difference in this review may be due to the small sample size of many included studies [20, 22, 26, 27] and their study design.…”

Section: Discussionmentioning

confidence: 64%

“…A total of 4223 blood cultures were obtained from the 10 included studies, 920 (21.79%) of which were performed exclusively in the paediatric population (children under 2 years old). The studies were conducted in two of the 10 regions of Cameroon and included patients from only two cities, Douala (n=2547; 60.31%) [20][21][22] and Yaoundé (n=1676; 39.69%) [23][24][25][26][27][28][29]. Most of the studies were cross-6 sectional (n=08) [20,[22][23][24][25][27][28][29], one was longitudinal [26] and one was retrospective [21], but all were of low risk.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The studies were conducted in two of the 10 regions of Cameroon and included patients from only two cities, Douala (n=2547; 60.31%) [20][21][22] and Yaoundé (n=1676; 39.69%) [23][24][25][26][27][28][29]. Most of the studies were cross-6 sectional (n=08) [20,[22][23][24][25][27][28][29], one was longitudinal [26] and one was retrospective [21], but all were of low risk. Only cross-sectional studies reported the age of the patients, which ranged from 0 to 92 years (Table S1).…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Bacterial Bloodstream Infections in Cameroon: A Systematic Review and Meta-Analysis of Prevalence and Antibiotic Resistance

Matakone,

Koudoum,

Zemtsa

et al. 2024

Preprint

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Background:The paucity of data on the epidemiology of bloodstream infection (BSI) in developing countries hampers its effective prevention and management. This review sought to provide the current prevalence, bacteriological and antimicrobial resistance profiles of bacteria implicated in BSI in Cameroon.Methods:PubMed and Google Scholar databases were searched to identify relevant articles. Data was analysed using comprehensive meta-analysis software. The I2was used to evaluate heterogeneity between studies, funnel plot and Egger's test to evaluate publication bias and random-effects analysis models to calculate pooled prevalence.Results:The 10 eligible studies were carried out in only two of the 10 regions of Cameroon and investigated 4,223 participants, of whom 920 were children under two years old. The overall pooled prevalence of bacterial BSI was 26.36% (95% CI= 17.51%-37.64%).Klebsiellaspp. (28.20%; 95%CI= 2.80%-63.60%),Escherichia coli(18.94%; 95%CI= 13.02%-26.72%) andStaphylococcus aureus(14.40%; 95%CI= 8.31%-23.81%) were the most incriminated bacteria species.E. coliandKlebsiellaspp. displayed the highest resistance to amoxicillin (82.6%; 95%CI= 63.3%-92.9 vs 86.4%; 95%CI= 55.9%-97.0%), amoxicillin + clavulanic acid (71.7%; 95%CI= 0.44%-89.2% vs 73.1%; 95%CI= 38.7%-92.1%) and trimethoprim/sulfamethoxazole (76.2%; 95%CI= 51.3%-90.7% vs 69.5%; 95%CI= 52.3-82.6%) respectively. However, meropenem (26.7%; 95%CI= 20.8%-33.7%) and fosfomycin (14.9%; 95%CI= 9.1%-23.4%) were the least resistant inE. coliandKlebsiellaspp. respectively.Staphylococcus aureusshowed high resistance to penicillin (84.4%; 95%CI= 68.1%-93.2%), erythromycin (41.5%; 95%CI= 28.0%-56.5%) and oxacillin (37.4%; 95%CI= 8.8%-78.7%) and low resistance to rifampicin (2.9%; 95%CI= 0.6%-13.4%), fusidic acid (8.1%; 95%CI= 3.4%-18.0%) and vancomycin (13.6%; 95%CI= 2.2%-52.9%).Conclusion:This study reports a high prevalence of bacterial BSIs in Cameroon and the high resistance of these bacteria to common antibiotics. There is a pressing need to conduct BSI surveillance studies in all regions of Cameroon to generate data for evidence-based measures regarding BSI prevention and management.Keywords:Bloodstream infection, epidemiology,Enterobacterales, antibiotic resistance, Cameroon.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 64%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Bacterial Bloodstream Infections in Cameroon: A Systematic Review and Meta-Analysis of Prevalence and Antibiotic Resistance

Matakone,

Koudoum,

Zemtsa

et al. 2024

Preprint

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Antibiotic Susceptibility Patterns of Bacteria Associated with Sepsis among Hospitalized Patients in the Yaoundé University Teaching Hospital—Cameroon

Cited by 1 publication

References 18 publications

Bacterial Bloodstream Infections in Cameroon: A Systematic Review and Meta-Analysis of Prevalence and Antibiotic Resistance

Bacterial Bloodstream Infections in Cameroon: A Systematic Review and Meta-Analysis of Prevalence and Antibiotic Resistance

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