Antibiotic susceptibility patterns of aerobic bacterial strains isolated from patients with burn wound infections

Vaez, Hamid; Beigi, Fahimeh

doi:10.11599/germs.2016.1087

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…On the contrary, the antimicrobial drugs that were found to be most active were amikacin and imipenem against Gram-negative species and vancomycin and trimethoprim/sulfamethoxazole versus Gram-positives. The efficacy of amikacin, vancomycin and imipenem was reported also in other studies [15]. Several studies, reported in literature, confirmed our results demonstrating that vancomycin appears to be the most effective antibiotic towards Gram-positive bacteria [36,41,44,49].…”

Section: Discussionsupporting

confidence: 91%

“…The detection of microbial species, pathogens distribution and antimicrobial susceptibility patterns are important aspects, often underestimated, in order to limit the spread of antibiotic-resistant isolates. In particular, the detection of the different microbial species colonizing a wound, as well as their susceptibility to the antimicrobials, can provide an indication for a more appropriate therapy to be administered to patients, significantly reducing the health care costs [15].…”

Section: Introductionmentioning

confidence: 99%

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Microbial Species Isolated from Infected Wounds and Antimicrobial Resistance Analysis: Data Emerging from a Three-Years Retrospective Study

et al. 2021

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The antimicrobial resistance is a topic of global interest in the treatment of wound infections. The goal of this retrospective study was both the identification of the microorganisms responsible for wound infections and the determination of their drug susceptibility pattern. The study was performed from 2017 to 2019 and included 239 patients. Thirty-four species were isolated by culture methods and identified and analysed for their susceptibility patterns to antimicrobials through the Walk Away automated system. The presence of one species was the most frequent condition (75.3%), whereas a co-infection was detected in 24.7% of samples. The most common species were Gram-negative (57.9%), amongst which the most prevalent were Pseudomonas aeruginosa (40.2%), Escherichia coli (20.7%), Proteus mirabilis (11.2%), and Acinetobacter baumannii/haemolyticus (9.5%). Gram-positive bacteria were observed in 36.6%, Staphylococcus aureus (79.4%) being the most predominant species. At least one resistance to antibiotics was detected in 88.2% of isolates, while a multi-drug-resistance versus no less than 6 antimicrobials was detected in 29.2% of isolates. Although multi-drug resistant species and co-infections were observed, those were less frequently observed at the wound site. These conditions make the microorganisms eradication more difficult. The detection of a polymicrobial infection and multi-drug resistant microorganisms followed by a proper therapeutic treatment would lead to the resolution of the infection, promoting wound healing and the limitation of the spread of antibiotic resistance.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Microbial Species Isolated from Infected Wounds and Antimicrobial Resistance Analysis: Data Emerging from a Three-Years Retrospective Study

et al. 2021

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“…In present study, P. aeruginosa isolates were mostly resistant against piperacillin (93.3%), ceftriaxone (93.3%), and aztreonam (86.7%). These findings are similar to other studies performed in Iran [ 4 , 5 ]. Salimi et al reported that many isolates of P. aeruginosa collected from burn patients referred to Mottahari hospital in Tehran province were resistant to used antibiotics, ceftizoxime (87%), aztreonam (80.2%), kanamycin (79.4%), and ceftazidime (74.8%) [ 6 ].…”

supporting

confidence: 93%

The emergence of multidrug-resistant clone ST664 Pseudomonas aeruginosa in a referral burn hospital, Isfahan, Iran

2017

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“…29 Other burn centres in Australia, Iran, Singapore and Turkey have also documented similar results with Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii being the most common pathogens responsible for burn wound infections. [30][31][32][33][34] Gram-negative pathogens (Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia Coli, Enterobacter spp. and Proteus spp.)…”

Section: Discussionmentioning

confidence: 99%

Bacterial and Antimicrobial Susceptibility Profile, and Prevalence of Sepsis Among Burn Patients at the Burn Unit of Cipto Mangunkusumo Hospital

Djan¹

2017

Preprint

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Infection is a major cause of mortality and morbidity among burn patients. An effective measure to reduce infection is routine monitoring of bacterial infection and antimicrobial susceptibility patterns at the burn unit. This will help to create a burn centre-specific empirical antibiotic therapy protocol. A retrospective, descriptive study was conducted at the Cipto Mangunkusumo Hospital (RSCM) Burn Unit between September-November 2016. Data regarding bacterial culture isolates, antimicrobial susceptibility spectrum, and the number of burn patients diagnosed with sepsis were collected. There were 36 patients with positive bacterial cultures, with the isolates changing continuously between Klebsiella pneumonia (17%), Pseudomonas Aeruginosa (12%) and Acinetobacter baumannii (11%). High resistance was found for 10 antimicrobials, particularly cephalosporins. The three bacteria were only sensitive to carbapenem, aminoglycosides and tigecycline. Fourteen patients were diagnosed with sepsis (38.9%), 10 died. Two major sepsis-causing bacteria were P. aeruginosa (33.3%) and K. pneumoniae (28.9%). Bacterial isolates in our setting changed every month. Almost all bacterial isolates are multi-drug resistant, highly resistant to the empirical therapy given (ceftriaxone), leading to outbreaks of sepsis and increased mortality rates. Carbapenem (imipenem, meropenem and doripenem) and aminoglycosides (amikacin) combination was the selected empirical therapy.

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Antibiotic susceptibility patterns of aerobic bacterial strains isolated from patients with burn wound infections

Cited by 11 publications

References 7 publications

Microbial Species Isolated from Infected Wounds and Antimicrobial Resistance Analysis: Data Emerging from a Three-Years Retrospective Study

Microbial Species Isolated from Infected Wounds and Antimicrobial Resistance Analysis: Data Emerging from a Three-Years Retrospective Study

The emergence of multidrug-resistant clone ST664 Pseudomonas aeruginosa in a referral burn hospital, Isfahan, Iran

Bacterial and Antimicrobial Susceptibility Profile, and Prevalence of Sepsis Among Burn Patients at the Burn Unit of Cipto Mangunkusumo Hospital

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