Antibiotic susceptibility pattern and genotyping of campylobacter species isolated from children suffering from gastroenteritis

El-Baky, Rehab Mahmoud Abd; Sakhy, M; Gad, Gamal Fadl Mahmoud

doi:10.4103/0255-0857.136550

Cited by 14 publications

(12 citation statements)

References 46 publications

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“…Dallal identified a frequency of 0.9% for Campylobacter strains in acute diarrhea among children younger than 5 years of age in south Tehran (19). Various studies have reported Campylobacter frequencies, such as 3.0% in Senegal, 8.4% in Uruguay, 9.6% in Egypt, 9.7% in Tanzania, 9.3% in Uganda, 10.5% in Romania, 11.0% in Sudan, 12.7% in Ethiopia, and 22.6% in Ghana (11,12,15,(20)(21)(22)(23)(24)(25). Therefore, the average contribution of Campylobacter strains to AGE in children was about 9% in most studies.…”

Section: Discussionmentioning

confidence: 99%

“…Campylobacter is one bacterial cause of AGE in developed countries (10). In developed countries, Campylobacter accounts for about 5% -20% of all cases of AGE in children younger than 5 years of age; in developing countries, this incidence ranges from 5% -35% (11,12). Campylobacter is transmitted through food and water and appears more often during the warm seasons (13) self-limiting in nature, antimicrobial therapy can reduce the severity of symptoms and shorten the course of the disease (14).…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Laboratory Characteristics of Pediatric Campylobacter spp. Acute Gastroenteritis

Mazaheri

Rezaei

Aalinezhad

et al. 2016

Arch Pediatr Infect Dis

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Background: Although Campylobacter strains are one cause of acute bacterial gastroenteritis, their clinical and laboratory findings have only been examined in a few studies. Objectives: This study was performed to evaluate the frequency level as well as the clinical and laboratory findings of patients with acute gastroenteritis caused by Campylobacter. Patients and Methods:In this cross-sectional study, 419 Iranian children in Semnan city with acute gastroenteritis were assessed for their clinical and laboratory findings, including fever, abdominal pain, vomiting, dehydration, the presence of red blood cells and white blood cells (WBCs) in the stool, and leukocytosis. After being prepared for testing, a sample of the patient's stool was also examined for the presence of Campylobacter strains through microscopic examination, culture, and chemical reactions.Results: There were 36 positive cultures (8.6%) for Campylobacter, with frequencies of 6.4% and 10.3% for boys and girls, respectively (P = 0.16). The highest frequency of positive culture belonged to the age group over six years (P = 0.02). The most common findings associated with Campylobacter diarrhea included abdominal pain (77.8% vs.1 8.8%, P < 0.001), fever (80.6% vs. 20.4, P < 0.001), leukocytosis (72.2% vs. 45.7%, P = 0.002), and WBCs in the stool (63.9% vs. 23.8%, P < 0.001). Conclusions: This study showed that abdominal pain, fever, leukocytosis, and WBCs in the stool were associated with gastroenteritis infection caused by Campylobacter.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Pediatric Campylobacter spp. Acute Gastroenteritis

Mazaheri

Rezaei

Aalinezhad

et al. 2016

Arch Pediatr Infect Dis

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“…However, gentamicin, amikacin and chloramphenicol were the most effective antibiotics for the in vitro treatment of C. jejuni and C. coli isolates from Egyptian children suffering from gastroenteritis [11].…”

Section: Control and Prevention Interventionsmentioning

confidence: 97%

“…Later on, Campylobacter spp. were identified from patients with gastroenteritis in Cairo, Egypt using conventional and polymerase chain reaction (PCR) methods in 6.6% of human stool samples [10,11]. Recently, the epidemiology of Campylobacter among an Egyptian pediatric population was described and the results pointed out to the variability in Campylobacter spp.…”

Section: Epidemiologymentioning

confidence: 99%

One health approach of campylobacteriosis in Egypt: An emerging zoonotic disease

El-Ghany

2019

J Infect Dev Ctries

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World Health Organization (WHO) defined zoonotic diseases as diseases transmitted from animals to humans and vice versa with or without vector, where more than 75% of the human’s diseases have been transmitted from animals or their products. Nevertheless, campylobacteriosis is still one of the most important food borne zoonotic diseases that is likely to challenge global public health all over the world. In Egypt, campylobacteriosis causes severe losses in comparison with other food borne pathogens like Salmonella or Escherichia coli. The potential sources of Campylobacter transmission are poultry backyards and meat, cattle meat, raw milk and water. The main clinical manifestations of human’s campylobacteriosis are gastroenteritis and later on nervous signs. Prevention and control strategic plans of campylobacteriosis are very crucial.

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“…Although campylobacteriosis is endemic in Egypt and considered a major cause for pediatric diarrhea [135], fluoroquinolone and macrolide resistance, was recently documented to increase in the isolated strains in Egypt [136][137][138][139][140][141][142][143][144][145][146][147]. In the period from 1991 to 2016, several studies screened and analyzed the resistance pattern of macrolides and FQ in campylobacters, especially C. jejuni and C. coli, in chickens and humans in several Governorates in Egypt as shown in Tables 2 and 3 [136][137][138][139][140][141][142][143][144][145][146][147]. Putnam [137] analyzed the annual prevalence of macrolides resistance rate in Cairo from 1995 till 2000, which was 0%.…”

Section: Incidence Of Resistance In Egyptmentioning

confidence: 99%

Macrolides and Fluoroquinolones Resistance Mechanisms in Campylobacters and their Incidence in Egypt; a Review Article

Tawab

Ammar

Ahmed

et al. 2019

Zagazig Veterinary Journal

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Campylobacter species are primarily zoonotic pathogens and recognized as a major cause of human illnesses. Poultry, especially, chicken is the main reservoir of Campylobacter species. The uncontrolled use of antibiotics in prophylaxis and treatment of animals caused an increase in antibiotic resistance to macrolides and fluoroquinolones (FQ) which are considered the drugs of choice for treatment of Campylobacter infection. Recently, studies suggested that multidrug efflux systems have the main role in lowering the efficacy of new and old antibiotics. Consequently, efforts are made to find suitable substances to reverse the action of the efflux pumps and prevent antimicrobial resistance. The substances used for evaluation of efflux pumps modulation are either efflux pump inhibitors (EPIs) or efflux pump inducers. The different types of EPIs; phenylalanine arginyl β-naphthylamide, verapamil and phenothiazines, of different mode of actions were used to suppress the activity of different types of efflux pumps. Aspirin, a drug in livestock and poultry, is a nonsteroidal anti-inflammatory, which induces non-heritable resistance of different bacteria to multiple antibiotics. Moreover, it also increases campylobacter resistance to antimicrobials. Alpha-tocopherol represents a new alternative approach against bacterial resistance. It shows modulatory activity on efflux system, showing clinically relevant results. Therefore, it is important to study different resistance mechanisms of campylobacters.

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Antibiotic susceptibility pattern and genotyping of campylobacter species isolated from children suffering from gastroenteritis

Abstract: PCR assay method allows reliable detection of C. jejuni. C. jejuni was the most prevalent Campylobacter species. Gentamicin, amikacin and chloramphenicol were the most effective antibiotic.

Cited by 14 publications

References 46 publications

Clinical and Laboratory Characteristics of Pediatric Campylobacter spp. Acute Gastroenteritis

Clinical and Laboratory Characteristics of Pediatric Campylobacter spp. Acute Gastroenteritis

One health approach of campylobacteriosis in Egypt: An emerging zoonotic disease

Macrolides and Fluoroquinolones Resistance Mechanisms in Campylobacters and their Incidence in Egypt; a Review Article

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