Antibiotic Susceptibility of Periodontal Streptococcus constellatus and Streptococcus intermedius Clinical Isolates

Abstract

Subgingival S. constellatus and S. intermedius exhibited variable antibiotic susceptibility profiles, potentially complicating empirical selection of periodontitis antibiotic therapy in patients who are species positive.

Changes in antimicrobial susceptibility profile and prevalence of quinolone low-sensitive strains in subgingival plaque from acute periodontal lesions after systemic administration of sitafloxacin

“…Moreover, nearly all subgingival isolates of yellow complex species (streptococci) were susceptible to sitafloxacin, although Streptococcus strains resistant to levofloxacin, azithromycin or clindamycin were identified during the course of the periodontal treatment. These findings are in line with the recent report by Rams et al [24], which showed the variable antibiotic susceptibility profiles of some of the subgingival streptococci.…”

Glycaemic status affects the subgingival microbiome of diabetic patients

“…An earlier study reported that S. intermedius levels were higher in supragingival but not in subgingival plaque of T2DM patients when compared to controls (Hintao, Teanpaisan, Chongsuvivatwong, Ratarasan, & Dahlen, ). SAG seems to be resistant to periodontal therapy, as their levels remain high in periodontal sites after periodontal treatment (Feres et al., ) and are resistant to multiple antimicrobials (Rams, Feik, Mortensen, Degener, & van Winkelholf, ). In addition, these organisms are involved in invasive infections, demonstrated by their ability to cause abscesses (Asam & Spellerberg, ).…”

“…Inadequate glycaemic control was associated with increasing levels of succinate/acetate producers and decreased levels of butyrate producers, which may interfere with the immune response against subgingival microbiota. The altered microbial profile may also influence periodontal treatment outcomes by selecting species resistant to mechanical treatment and even to antibiotics commonly used in the periodontal therapy, such as the anginosus group of streptococci (Feres et al., ; Rams et al., ). Furthermore, our data suggest that shifts in microbiome signatures in T2DM patients with inadequate glycaemic control may play a role locally in periodontal tissues and increase the risk of infection diseases commonly associated with diabetes, by selection of pathobionts such as S. agalactiae .…”

Bioaerosols in an Underground Tourist Trail

“…constellatus oral cavity, gastrointestinal tract [42,43] potential role in chronic periodontitis [44] NDA Note: NDA -no data available production of mycotoxins. Special attention should be paid to filamentous fungi that belong to primary colonizers -fungi able to grow in the lowest water activity environment, i.e., Penicillum expansum [45][46][47].…”