Antibiotic Susceptibility of Neisseria gonorrhoeae Isolates from Guangzhou, China, during 2002–2011

Zheng, Heping; Yang, Bin; Wu, Xingzhong; Huang, Jinmei; Zeng, Weiying; Xue, Yaohua; Qin, Xiaolin; Lan, Yinyuan; Tang, Sanmei; Ou, Jiangli; Li, Yixin

doi:10.7883/yoken.67.288

Cited by 10 publications

(4 citation statements)

References 17 publications

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“…Since 1992, China has been part of the WHO Western Pacific Region (WPR) Resistance Surveillance Program; however, for several years, the reported data were only limited to several cities, such as Guangzhou (14), Nanjing (15), and Shanghai (16), and the AMR profiles were basically consistent with the patterns found in other regions of the WPR. To our knowledge, there has been no monitoring the AMR of N. gonorrhoeae in Changsha, a megacity close to Guangzhou, where STD incidence is one of the highest in China.…”

mentioning

confidence: 93%

Surveillance of the Antimicrobial Susceptibility of <i>Neisseria gonorrhoeae</i> Isolates Collected in Changsha, China from 2003 to 2015

et al. 2017

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confidence: 93%

Surveillance of the Antimicrobial Susceptibility of <i>Neisseria gonorrhoeae</i> Isolates Collected in Changsha, China from 2003 to 2015

et al. 2017

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“…Studies have shown that changes in the bacteria environment was the main reason for the appearance of drug-resistant strains, and not the uneven distribution of infections across different hospitals or wards [ 10 , 11 ]. In recent years, owing to the broad application of antibiotics in hospital as well as self-medication in communities in China, bacteria drug-resistance has reached very high levels [ 12 ]. This prompted the Chinese Health Ministry to issue guidelines for a better use of antimicrobial drugs in hospitals.…”

Section: Introductionmentioning

confidence: 99%

Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China

et al. 2017

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BackgroundTo understand the relationship between the Staphylococcus aureus infection rate and the reasonable usage of antibiotics, which will help in the effective control of MRSA infection.MethodsAll data were obtained by the application of the nosocomial infection surveillance network. Drug resistance, departmental sources, and isolated sites as well as infection rate variations of S. aureus were analyzed in the 7-year period in key departments.ResultsBetween 2008 and 2014, 2525 strains of S. aureus isolates, mainly from sputum, skin/soft tissue, bloodstreams were collected from several hospital departments including respiratory, burn, brain surgery, orthopedics, ICU, and emergency. During these periods, the resistance rate of S. aureus to most drugs, including oxacillin, tetracycline, erythromycin, clindamycin, gentamicin, and ciprofloxacin, showed a tendency to decrease. The resistance to sulphamethoxazole/trimethoprim showed the opposite trend (P = 0.075) and there were no S. aureus strains resistant to linezolid and vancomycin. The MRSA infection rate was different across crucial hospital departments, with the burns department and ICU maintaining a high infection level. Over the 7-year period, both the brain surgery and the emergency departments had an expected upward trend (P < 0.05), while the orthopedic department showed a clear downward trend (P < 0.05) in MRSA infection rate.ConclusionHospitals should continue to maintain the current pattern of antibiotic administration, while more effective measures should be taken to reduce the high MRSA infection rate in some important hospital departments.

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“…Compounding HAI-related issues, antibiotic resistance among pathogens is a serious problem, owing to drug abuse stemming from hospital over-prescription as well as excessive self-medication in Chinese communities [6]. Furthermore, multidrug-resistant (MDR) bacteria have become increasingly prevalent, with notable examples being methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamase (ESBL)-positive Escherichia coli [7].…”

Section: Introductionmentioning

confidence: 99%

Drug Resistance of Pathogens Causing Nosocomial Infection in Orthopedics from 2012 to 2017: A 6-Year Retrospective Study

Yang

Guo

Xie

et al. 2020

Preprint

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Background: Hospital-acquired infections (HAIs) are an emerging global problem that increases in-hospital mortality, length of stay, and cost. We performed a 6-year retrospective study to provide valuable insight into appropriate antibiotic use in HAI cases. We also aimed to understand how hospitals could reduce pathogen drug resistance in a population that overuses antibiotics.Methods: All data (2012–2017) were obtained from the Hospital Information Warehouse and Clinical Microbiology Laboratory.Results: We isolated 1392 pathogen strains from patients admitted to the orthopedics department during 2012–2017. Escherichia coli (14.7%, 204/1392), Enterobacter cloacae (13.9%, 193/1392), and Staphylococcus aureus (11.3%, 157/1392) were the most common pathogens causing nosocomial infections. The dominant Gram-negative bacterium was E. coli, with high resistance to ampicillin, levofloxacin, cotrimoxazole, gentamicin, and ciprofloxacin, in that order. E. coli was least resistant to amikacin, cefoperazone-sulbactam. The most dominant Gram-positive bacterium was S. aureus, highly resistant to penicillin and ampicillin, but not resistant to fluoroquinolones and cotrimoxazole. Analysis of risk factors related to multidrug-resistant bacteria showed that patients with open fractures were significantly more susceptible to methicillin-resistant S. aureus infections (p < 0.05). Additionally, extended-spectrum β-lactamase-producing E. coli infections occurred significantly more often in patients with degenerative diseases (p < 0.05). Elderly patients tended to be more susceptible to multidrug-resistant bacterial infections, but this outcome was not statistically significant.Conclusions:Antimicrobial resistance is a serious problem in orthopedics. To effectively control antimicrobial resistance among pathogens, we advocate extensive and dynamic monitoring of MDR bacteria, coupled with careful use of antibiotics.

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Antibiotic Susceptibility of Neisseria gonorrhoeae Isolates from Guangzhou, China, during 2002–2011

Cited by 10 publications

References 17 publications

Surveillance of the Antimicrobial Susceptibility of <i>Neisseria gonorrhoeae</i> Isolates Collected in Changsha, China from 2003 to 2015

Surveillance of the Antimicrobial Susceptibility of <i>Neisseria gonorrhoeae</i> Isolates Collected in Changsha, China from 2003 to 2015

Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China

Drug Resistance of Pathogens Causing Nosocomial Infection in Orthopedics from 2012 to 2017: A 6-Year Retrospective Study

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