Antibiotic Susceptibility of Klebsiella pneumoniae isolated from Selected Tertiary Hospitals in Osun State, Nigeria

Abstract

Klebsiella pneumoniae is a pathogen of the Enterobacteriaceae family that causes healthcare-associated infections and has recently emerged as one of the most antibiotic-resistant organisms responsible for outbreaks in both community and healthcare settings. The aim of this study is to determine the resistance pattern of Klebsiella pneumoniae isolated from selected tertiary hospitals in Osun state, Nigeria. A total of 62 Klebsiella pneumoniae isolates were obtained from 1056 samples of urine, wound swab, ear swab, eye swab and other collection sites that were routinely submitted to the diagnostic laboratories of the selected tertiaryhospitals. Susceptibility to twelve (12) antibiotics (Oxoid) was determined using the Kirby Bauer disk diffusion method for the 62 isolates. Rate of resistance to carbapenems, fluoroquinolones, polymyxins, monobactams, cephalosporins, penicillin and phosphonic acid derivative are 29.03%, 47.84%, 29.03%, 46.77%, 50.80%, 93.55%, and 37.10% respectively. The isolates were mostly susceptible to carbapenems, especially, Imipenem with 74.19%. Highest resistance was to Penicillin (93.55%). The multiple antibiotic resistance (MAR) index revealed that 52 (83.87%) out of 62 isolates were multi-drug resistant. Increase in antibiotic resistance continues to be a problem amidst patients infected with Klebsiella pneumoniae which can be most likely attributed to increase in antibiotic misapplication, misuse and abuse which is most prevalent among youths. It is therefore of utmost importance that consistent monitoring of antibiotic resistance be done as it will assist in the appropriate selection of empiric antibiotic treatment in the proper setting.

Prevalence of antimicrobial resistance in Klebsiella pneumoniae, Enterobacter cloacae and Escherichia coli isolates among stillbirths and deceased under-five children in Sierra Leone: Data from the Child Health and Mortality Prevention Surveillance sites from 2019 to 2022

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Molecular modelling of SdiA protein by selected flavonoid and terpenes compounds to attenuate virulence in Klebsiella pneumoniae

“…K. pneumoniae has the ability to colonize the gastrointestinal system, nasopharynx, and skin causing a wide range of infections, ranging from minor to life-threatening (Tzouvelekis et al, 2012). Urinary tract infections (UTIs), soft tissue infections, intra-abdominal infections, septicaemia, wound or blood infections, and pneumonia are examples of such illnesses (Adeosun et al, 2019). The high resistance to several classes of antibiotics, including the last line of resort has been implicated in its biofilm-forming potential.…”

Tigecycline is the Most Effective against Multi-Drug Resistant Klebsiella pneumoniae Recovered from Burn Wound Infections in Two Hospitals in Al-Kut City, Iraq

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