Antibiotic susceptibility of bacteria isolated from infections in cats and dogs throughout Europe (2002–2009)

Kroemer, S.; Garch, Farid El; Galland, Delphine; Petit, Jean-Luc; Woehrle, Frédérique; Boulouis, Henri-Jean

doi:10.1016/j.cimid.2013.10.001

Cited by 44 publications

(44 citation statements)

References 13 publications

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“…Taking into account the low permeability of the cell wall and the presence of effl ux pumps [20], the broad range of β-lactamases produced, biofi lm production [21], and the high genetic versatility of this species, only a very limited number of antimicrobials are at the clinicians disposal. Enrofl oxacin and marbofl oxacin are licensed only for veterinary use, the latter being more active against P. aeruginosa [2,8]. A total of 349 P. aeruginosa strains isolated from dogs and cats were investigated [8], 23% of these proved to be resistant to marbofl oxacin, a lower ratio compared to our results (36.8%).…”

Section: Discussioncontrasting

confidence: 54%

“…It has better activity [2,7,8] and a longer postantibiotic effect against the pathogen compared to enrofl oxacin [9]. 91.3% incidence of sensitivity to marbofl oxacin was reported in Pseudomonas spp.…”

Section: Introductionmentioning

confidence: 99%

“…Pseudomonas aeruginosa is a frequently isolated Gram-negative bacterium in veterinary practice, associated mainly with external otitis, deep pyoderma, keratoconjunctivitis, respiratory and urinary tract infections [1,2]. This bacterium can develop resistance rapidly against several antibiotics, even during the course of antimicrobial treatment [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa

Jerzsele

Pásztiné-Gere

2015

Acta Microbiologica Et Immunologica Hungarica

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The aim of this study was to determine antimicrobial susceptibility of Pseudomonas aeruginosa strains to marbofl oxacin and gentamicin, and investigate the possible synergistic, additive, indifferent or antagonistic effects between the two agents. P. aeruginosa strains can develop resistance quickly against certain antibiotics if used alone, thus the need emerges to fi nd synergistic combinations. A total of 68 P. aeruginosa strains isolated from dogs were examined. In order to describe interactions between marbofl oxacin and gentamicin the checkerboard microdilution method was utilized. The MICs (minimum inhibitory concentrations) for marbofl oxacin and gentamicin were in the range 0.25-64 mg/L and 0.25-32 mg/L, respectively. The combination of marbofl oxacin and gentamicin was more effective with a MIC range of 0.031-8 mg/L and a MIC 90 of 1 mg/L, compared to 16 mg/L for marbofl oxacin alone and 8 mg/L for gentamicin alone. The FIC (fractional inhibitory concentration) indices ranged from 0.0945 (pronounced synergy) to 1.0625 (indifference). Synergy between marbofl oxacin and gentamicin was found in 33 isolates. The mean FIC index is 0.546, which represents a partial synergistic/additive effect close to the full synergy threshold. In vitro results indicate that marbofl oxacin and gentamicin as partially synergistic agents may prove clinically useful in combination therapy against P. aeruginosa infections. Although marbofl oxacin is not used in the human practice, the interactions between fl uoroquinolones and aminoglycosides may have importance outside the veterinary fi eld.

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa

Jerzsele

Pásztiné-Gere

2015

Acta Microbiologica Et Immunologica Hungarica

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“…and from companion animals (E. coli, Pseudomonas aeruginosa, Staphylococcus intermedius) have shown success with the use of marbofloxacin (de MEUNIER et al, 2004a,b). This is suggestive that marbofloxacin can be used as an alternative antimicrobial to treat various clinical conditions in animals, particularly those of the urinary, respiratory, and dermatological tracts (KROEMER et al, 2014).…”

Section: Aminoglycosidesmentioning

confidence: 99%

Antimicrobial multiple resistance index, minimum inhibitory concentrations, and extended-spectrum beta-lactamase producers of Proteus mirabilis and Proteus vulgaris strains isolated from domestic animals with various clinical manifestations of infection

Zappa¹,

Bolaños

Paula

et al. 2017

SCA

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Proteus spp. are opportunistic multidrug resistant enterobacteria associated with diverse clinical diseases in domestic animals. However, Proteus infections in domestic animals are often misdiagnosed or considered contaminants in microbiological cultures rather than a primary agent of disease. Descriptions of Proteus infections in domestic animals are typically restricted to case reports, retrospective studies, or surveillance of other microorganisms. The present study investigated multiple antibiotic resistance indices, minimum inhibitory concentrations (MICs), and ESBL production in 73 strains of Proteus mirabilis (n = 69) and Proteus vulgaris (n = 4) isolated from domestic animals with various clinical manifestations. In dogs, the pathogen was most commonly associated with cystitis (48.21), enteritis (21.42%), otitis (14.29%), and conjunctivitis (3.57%). In bovines, the microorganism was predominant in cases of enteritis (22.22%), abscess (11.11%), otitis (11.11%), omphalitis (11.11%), and peritonitis (11.11%), and in organ fragments (11.11%). In equines (50.0%) and cats (100.0%), diarrhea was the main clinical sign. In vitro standard disk diffusion assay showed that the most effective antimicrobials against the isolates were imipenem (98. novobiocin (95.89), azithromycin (57.53), and trimethropim/sulfamethoxazole (39.73). Among the 73 isolates, the efficacy of amoxicillin/clavulanic acid, gentamicin, ceftriaxone, and ciprofloxacin according to MICs was 87.67%, 86.30%, 84.93%, and 82.19%, respectively. The MIC 50 values of amoxicillin/clavulanic acid, ceftriaxone, ciprofloxacin, and gentamicin were, respectively, 1.0, 0.004, 0.03, and 1.0 µg/mL. Thirty-three strains (45.21%) showed a antimicrobial multiple resistance index of ≥0.3. Multidrug resistance profiles of isolates were observed most frequently in dogs (n = 25; 75.76%), particularly in those with cystitis (n = 13; 52.0%), followed by bovines (n = 4; 12.12%), equines (n = 2; 6.06%), and cats (n = 2; 6.06%). Two (2.7%) strains, obtained from canine skin and feces, were diagnosed phenotypically as ESBL-producers. Here, we observed the diversity of Proteus infections in domestic animals. The presence of multidrug-resistant isolates and ESBL-producers reinforces the need for appropriate antimicrobial use and in vitro antimicrobial tests to support therapy. Key words: Proteus sp. Multidrug resistant. Extended-spectrum beta-lactamase. Livestock. Companion animals. ResumoProteus spp. são enterobactérias oportunistas, multirresistentes aos antimicrobianos, associadas a diversas infecções em animais domésticos. No entanto, as infecções por Proteus em animais de produção e de companhia são negligenciadas ou, por vezes, o patógeno é considerado "contaminante", ainda que em infecções como agente primário. Os registros de infecções por Proteus sp. em animais domésticos estão restritos aos relatos de casos, estudos retrospectivos ou compondo estudos com outros microorganismos. O presente estudo investigou o índice de resistência múltipla (IRMA) e a concentra...

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“…Severe conditions include extraintestinal infections and complications caused by toxins produced by verotoxigenic E. coli (1,2). In animals, E. coli may cause urinary and gastrointestinal tract infections, septicaemia and respiratory tract infections (3,4).…”

Section: Introductionmentioning

confidence: 99%

Quinolone-resistant Escherichia coli in Poultry Farming

Hricová¹,

Röderová²,

Pudová³

et al. 2017

Cent Eur J Public Health

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SUMMARYIncreasing bacterial resistance to quinolone antibiotics is apparent in both humans and animals. For humans, a potential source of resistant bacteria may be animals or their products entering the human food chain, for example poultry. Between July 2013 and September 2014, samples were collected and analyzed in the Moravian regions of the Czech Republic to isolate the bacterium Escherichia coli. As a result, 212 E. coli isolates were obtained comprising 126 environmental isolates from poultry houses and 86 isolates from cloacal swabs from market-weight turkeys. Subsequently, the E. coli isolates were tested for susceptibility to selected antibiotics. Resistance of the poultry isolates to quinolones ranged from 53% to 73%. Additionally, the presence of plasmid-mediated resistance genes was studied. The genes were confirmed in 58% of the tested strains. The data on resistance of isolates from poultry were compared with results of resistance tests in human isolates obtained in the same regions.The high levels of resistance determined by both phenotyping and genotyping methods and reported in the present study confirm the fact that the use of fluoroquinolones in poultry should be closely monitored.

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Antibiotic susceptibility of bacteria isolated from infections in cats and dogs throughout Europe (2002–2009)

Cited by 44 publications

References 13 publications

Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa

Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa

Antimicrobial multiple resistance index, minimum inhibitory concentrations, and extended-spectrum beta-lactamase producers of Proteus mirabilis and Proteus vulgaris strains isolated from domestic animals with various clinical manifestations of infection

Quinolone-resistant Escherichia coli in Poultry Farming

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