Antibiotic Susceptibility Evaluation of Bacterial Agents Causing Infection in Children with Acute Tonsillopharyngitis

Abstract

Background: The aim of this study is to evaluate the prevalence of group A beta-hemolytic pharyngitis by assessing the outcome of the culture and the resistance and sensitivity of group A beta hemolytic streptococcus to antibiotics. Methods: This cross-sectional study was conducted on 170 patients, aged 3-15 years, referred to the clinic with complaints of sore throat. Patients’ history was collected and physical examination was performed and were score based on clinical findings. Patients with other underlying pathologies and those taking antibiotics prior to the study were excluded from our study. Antimicrobial susceptibility test was performed by disk diffusion method against cephalexin, cefazolin, erythromycin and amoxicillin. Results: A total of 170 patients were reported with sore throat. Patients with positive culture results were 60% male and 40% female. Amoxicillin resistance was the greatest (5%) in the culture. All isolated bacteria were sensitive to amoxicillin, cephalexin, cefazolin and erythromycin. Patients with McIssac score ≥ 6 showed clinical sensitivity 75% specificity 61% negative predictive value 94.8% and positive predictive value 20.3% for Group A beta-hemolytic streptococcal pharyngitis. Conclusion: The results showed the higher the clinical score, the greater the chance of positive throat culture.

Prevalence, Antibiotic Susceptibility Profile and Associated Factors of Group A Streptococcal pharyngitis Among Pediatric Patients with Acute Pharyngitis in Gondar, Northwest Ethiopia

“… 41 It is also similar to studies from different countries such as Turkey 7.5%, 42 Indonesia 7.9%, 43 Morocco 9.1%, 44 and Iran 11.8%. 45 However, it was higher than reports from Morocco 6.2%, 46 India 5.5%, 47 Romania 4%, 48 Northern India 2.8%, 49 and Iran 2.5%. 50 On the other hand, it was lower than estimates from Pakistan 25.3%, 51 India 28.4%, 52 Iran 30%, 53 and Yemen 41.5%.…”

“… 14 , 62 In our study, all the GAS isolates were susceptible to penicillin, which is also reported by several studies worldwide. 30 , 31 , 41 , 45 , 46 Hence, given its narrow spectrum, low cost, and efficacy in preventing strep throat complications such as RHD and PSGN, penicillin remains the drug of choice for treating GAS pharyngitis. 17 Our findings reveal that vancomycin 4.3% and ceftriaxone 13% have reduced susceptibility against GAS causing pharyngitis.…”

Distribution of Pathogenic Bacterial Causing Urinary Tract Infection and their Sensitivity and Resistant to Antibiotics

“…UTI is related with increased health burden among pediatric patients (3). UTI is the most common genitourinary tract disease and the second most common bacterial infection (after respiratory tract infections) in childhood.…”