Antibiotic Susceptibility Among Aerobic Gram-negative Bacilli in Intensive Care Units in 5 European Countries

Hanberger, Håkan; Garcı́a-Rodrı́guez, J.A.; Gobernado, M; Goossens, Herman; Nilsson, Lennart; Struelens, Marc

doi:10.1001/jama.281.1.67

Cited by 294 publications

(176 citation statements)

References 23 publications

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“…In a multicenter study from 5 European countries, the percentage of probable ESBL producers was lower than the percentage found in our study. In that study the highest percentages were found in Portugal (36.0%) and in France (26.0%) [1]. Another interesting observation in this study was the important difference in the resistance rates for aminoglycosides between strains isolated from inpatients and outpatients (Table 1).…”

Section: Antimicrobial Susceptibility Of Klebsiella Pneumoniaesupporting

confidence: 51%

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Multicenter evaluation of resistance patterns of Klebsiella pneumoniae, Escherichia coli, Salmonella spp and Shigella spp isolated from clinical specimens in Brazil: RESISTNET surveillance program

Oplustil¹,

Nunes²,

Mendes³

2001

Braz J Infect Dis

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Surveillance programs are essential to detect the increase of antimicrobial resistance, and several different programs are being conducted in many countries. The RESISTNET is a surveillance program for bacterial resistance against several antimicrobial agents initiated in 1998 among Latin American countries. In Brazil, several centers were invited to join this surveillance and a total of 11 centers (6 from São Paulo and 5 from other states) participated in the study. All results were analyzed using the WHONET program. A total of 894 Escherichia coli, 386 Klebsiella pneumoniae, 70 Shigella spp and 57 Salmonella spp strains were analyzed in this study from April, 1998, to April, 1999. Susceptibility testing was performed by the disk diffusion method using NCCLS 1998 guidelines for several different drugs. For all strains, imipenem was the most effective drug (100% of the strains were susceptible). Klebsiella pneumoniae presented a high resistance rate to ampicillin (96.4%). The rate of probable ESBL producers among K. pneumoniae strains was 36.3%, most of them being isolated from catheters (58.8%). Among all Escherichia coli strains analyzed, the highest resistance rate was found for trimethoprim/ sulfamethoxazole (46.9%) and the majority of the resistant strains were isolated from urine samples (47.8%). Among Salmonella spp, the resistance rates were low for all antibiotics tested. For Shigella spp strains there was a high resistance to trimethoprim/sulfamethoxazole (80.0%). No resistance to ceftriaxone was observed in these strains. Surveillance of antimicrobial resistance is critical for the successful management of infectious diseases. The results of this survey show significant resistance rates among these bacteria which are responsible for several types of human infections.

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Section: Antimicrobial Susceptibility Of Klebsiella Pneumoniaesupporting

confidence: 51%

“…The increase in antimicrobial resistance of bacteria to different antimicrobials leads many countries to initiate surveillance programs [1][2][3]. From all bacteria that have developed resistance, the Enterobacteriaceae are a group of special concern due to the high increase of resistance recently observed.…”

mentioning

confidence: 99%

Multicenter evaluation of resistance patterns of Klebsiella pneumoniae, Escherichia coli, Salmonella spp and Shigella spp isolated from clinical specimens in Brazil: RESISTNET surveillance program

Oplustil¹,

Nunes²,

Mendes³

2001

Braz J Infect Dis

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“…The resistance rates of Acinetobacter isolates were 10-51% against amikacin, 0-81% against gentamicin, 0-81% against ceftazidime, 19-81% against ciprofloxacin, 36-75% against piperacillin/tazobactam, and 5-19% against imipenem, as reported in a surveillance study from the intensive care units (ICU) of five European countries (13) . A. baumannii strains collected from 11 European countries between 1997 and 2000 were reported to be susceptible to imipenem and meropenem, with resistance rates of 16% and 18%, respectively (14) .…”

Section: Discussionmentioning

confidence: 67%

Antimicrobial susceptibility of Acinetobacter clinical isolates and emerging antibiogram trends for nosocomial infection management

Sohail

Rashid

Aslam

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:The drug resistant Acinetobacter strains are important causes of nosocomial infections that are difficult to control and treat. This study aimed to determine the antimicrobial susceptibility patterns of Acinetobacter strains isolated from different clinical specimens obtained from patients belonging to different age groups. Methods: In total, 716 non-duplicate Acinetobacter isolates were collected from the infected patients admitted to tertiary-care hospitals at Lahore, Pakistan, over a period of 28 months. The Acinetobacter isolates were identified using API 20E, and antimicrobial susceptibility testing was performed and interpreted according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: The isolation rate of Acinetobacter was high from the respiratory specimens, followed by wound samples. Antibiotic susceptibility analyses of the isolates revealed that the resistance to cefotaxime and ceftazidime was the most common, in 710 (99.2%) specimens each, followed by the resistance to gentamicin in 670 (93.6%) isolates, and to imipenem in 651 (90.9%) isolates. However, almost all isolates were susceptible to tigecycline, colistin, and polymyxin B. Conclusions: The present study showed the alarming trends of resistance of Acinetobacter strains isolated from clinical specimens to the various classes of antimicrobials. The improvement of microbiological techniques for earlier and more accurate identification of bacteria is necessary for the selection of appropriate treatments.

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“…[4][5][6] Recent reports confirm that mortality continues to remain significantly higher in patients who have received inadequate antimicrobial therapy. 7 These persistent problems suggest that novel strategies need to be devised to more effectively prevent and treat burn wound infections. Considering the increased bacterial resistance to conventional antibiotics, present studies focus on investigating the biological activity of recently described naturally occurring host defense peptides (HDP).…”

Section: Introductionmentioning

confidence: 99%

Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections

et al. 2005

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Antibiotic Susceptibility Among Aerobic Gram-negative Bacilli in Intensive Care Units in 5 European Countries

Cited by 294 publications

References 23 publications

Multicenter evaluation of resistance patterns of Klebsiella pneumoniae, Escherichia coli, Salmonella spp and Shigella spp isolated from clinical specimens in Brazil: RESISTNET surveillance program

Multicenter evaluation of resistance patterns of Klebsiella pneumoniae, Escherichia coli, Salmonella spp and Shigella spp isolated from clinical specimens in Brazil: RESISTNET surveillance program

Antimicrobial susceptibility of Acinetobacter clinical isolates and emerging antibiogram trends for nosocomial infection management

Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections

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