Antibiotic susceptibilities and auxotypes of Neisseria gonorrhoeae strains from women with pelvic inflammatory disease or uncomplicated infections

Jacques, Mario; Turgeon, Pierre; Derepentigny, J; Mathieu, L. G.

doi:10.1128/aac.24.6.952

Cited by 1 publication

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References 14 publications

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“…The nutrients used for auxotyping included ornithine, arginine, proline, uracil, hypoxanthine, leucine and methionine. Several auxotypes were defined; however, little association was found between different auxotypes and gonococcal pathogenesis [7, 159–161]. One exception to this is a correlation between DGI and the arginine, hypoxanthine, uracil (AHU) − auxotype with unknown causal mechanisms [162, 163]; another is dependence on lactate metabolism for long-term survival in human cervical epithelial cells, potentially vital for invasion and spread [164].…”

Section: Gonococcal Virulence Factors Are Diverse Which May Influence...mentioning

confidence: 99%

Bacterium of one thousand and one variants: genetic diversity of Neisseria gonorrhoeae pathogenicity.

Kurzyp,

Harrison

2023

Microbial Genomics

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The bacterium Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhoea. Although diverse clinical manifestations are associated with gonorrhoea, ranging from asymptomatic through to localized and disseminated infection, very little is known about the bacterial determinants implicated in causing such different clinical symptoms. In particular, virulence factors, although defined and investigated in particular strains, often lack comprehensive analysis of their genetic diversity and how this relates to particular disease states. This review examines the clinical manifestations of gonorrhoea and discusses them in relation to disease severity and association with expression of particular virulence factors including PorB, lipooligosaccharide (LOS) and Opa, both in terms of their mechanisms of action and inter- and intra-strain variation. Particular attention is paid to phase variation as a key mechanism of genetic variation in the gonococcus and the impact of this during infection. We describe how whole-genome-sequence-based approaches that focus on virulence factors can be employed for vaccine development and discuss whether whole-genome-sequence data can be used to predict the severity of gonococcal infection.

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Section: Gonococcal Virulence Factors Are Diverse Which May Influence...mentioning

confidence: 99%

Bacterium of one thousand and one variants: genetic diversity of Neisseria gonorrhoeae pathogenicity.

Kurzyp,

Harrison

2023

Microbial Genomics

View full text Add to dashboard Cite

show abstract

Antibiotic susceptibilities and auxotypes of Neisseria gonorrhoeae strains from women with pelvic inflammatory disease or uncomplicated infections

Cited by 1 publication

References 14 publications

Bacterium of one thousand and one variants: genetic diversity of Neisseria gonorrhoeae pathogenicity.

Bacterium of one thousand and one variants: genetic diversity of Neisseria gonorrhoeae pathogenicity.

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