Antibiotic sensitivity pattern of bacteria from diabetic foot infections Haji Adam Malik central general hospital

Bulolo, B A; Pase, M. Aron; Ginting, Franciscus

doi:10.1088/1755-1315/125/1/012052

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…In this study, it was found that the mean age of patients with DFI was 53.9 years old. This is in accordance with the results of several other local studies that reported the average age of DFI patients to be over 50 years old ( 9 – 10 ). The majority of the patients with DFI in the present study were female.…”

Section: Discussionsupporting

confidence: 93%

“…Research by Pemayun and Naibaho ( 9 ) conducted at the Dr Kariadi General Hospital Medical Centre Semarang reported that Gram-negative bacillus was found in 70.8% of DFI cases. Another local study conducted by Bulolo et al ( 10 ) at the Haji Adam Malik General Hospital Medan also reported that the most common bacteria found in DFI were Gram-negative bacilli with Klebsiella pneumonia (33.3%) as the predominant bacteria finding, followed by Escherichia coli (24.2%) and Acinetobacter baumannii (12.15%). Similar findings have previously been reported by various studies from other Southeast Asian countries ( 12 – 13 , 22 – 24 ).…”

Section: Discussionmentioning

confidence: 88%

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Bacteriological Profile and Antibiotic Susceptibility Pattern of Diabetic Foot Infection in a Tertiary Care Hospital in Lampung, Indonesia

Darwis¹,

Wang²,

Wisnu³

et al. 2021

MJMS

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Background: Diabetic foot infection (DFI) is a serious complication of diabetes mellitus and identification of the causative bacteria is an essential step in selecting the appropriate antibiotic therapy. This study aimed to evaluate the bacterial pattern and antibiotic susceptibility of the bacteria causing DFI in Lampung Province in Indonesia. Methods: This study is a retrospective study reviewing the medical records of DFI patients admitted to the Dr Hi Abdul Moeloek Regional General Hospital in 2017–2019. DFI patients with complete medical record data were included in this study. Demographic, clinical, laboratory, wound culture and antibiotic susceptibility data were collected from the medical records using a short structural chart. The data obtained then reviewed. Results: In this study, 131 DFI patients met the study criteria and were included. Based on the wound culture results, Gram-negative bacteria were obtained in 112 (85.5%) subjects with Enterobacter spp. as the predominant bacteria. Gram-positive bacteria were found in 19 (14.5%) subjects with Staphylococcus spp. as the predominant bacteria. Gram-negative bacteria found in this study showed high susceptibility to amikacin, meropenem and sulbactam/cefoperazone. Meanwhile, the Gram-positive bacteria showed high susceptibility to meropenem, sulbactam/ cefoperazone and amikacin. Conclusion: The findings of the study revealed Enterobacter spp. as the most predominant bacteria causing DFI in the studied population. The highest antibiotic susceptibility was seen for amikacin, meropenem and sulbactam/cefoperazone.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 88%

Bacteriological Profile and Antibiotic Susceptibility Pattern of Diabetic Foot Infection in a Tertiary Care Hospital in Lampung, Indonesia

Darwis¹,

Wang²,

Wisnu³

et al. 2021

MJMS

View full text Add to dashboard Cite

show abstract

“…Because of their higher blood glucose levels, weakened immune systems, neuropathy, and reduced blood supply to their extremities, diabetics are more susceptible to infections and wounds that heal slowly. Numerous bacteria can lead to infections in diabetes people [10,11].…”

Section: Introductionmentioning

confidence: 99%

Carbapenemase-Producing Klebsiella pneumoniae Infections in Diabetic and Nondiabetic Hospitalized Patients

Pattolath,

Adhikari,

Pai

2024

Cureus

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Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has recently attracted widespread attention due to its limited treatment options and significant morbidity and mortality rates. This study aimed to examine the relationship between risk factors and antimicrobial resistance in individuals with and without diabetes for the development of carbapenemase-producing K. pneumoniae infections.Methods: Between May 2019 and January 2021, a prospective study involving patients with and without diabetes who were infected with K. pneumonia, was carried out in a tertiary care hospital. Six hundred K. pneumoniae isolates were collected from various clinical samples, such as pus/wound samples, urine, respiratory samples, blood, and body fluids. An antimicrobial susceptibility test in K. pneumoniae was performed and compared between diabetics and nondiabetics. Univariate and multivariate logistic regression were used to identify independent risk factors for K. pneumoniae infections in the diabetic group and nondiabetic group separately. Multiplex PCR was used to detect genes that produce carbapenemase.Results: A total of 600 patients were infected with K. pneumoniae, with 300 (50%) being diabetic and 300 (50%) being nondiabetic. We found that diabetics had higher antimicrobial resistance to numerous routinely used drugs for infection than the nondiabetic group. In the multivariate analysis of the variables, it was found that immunosuppressive therapy, prior antibiotic use, mechanical ventilation, and urinary catheter use were all significant risk factors influencing the development of K. pneumoniae infections in diabetic patients. Diabetics had a higher prevalence of carbapenemase-producing K. pneumoniae than nondiabetics. Outcome measures in K. pneumoniae patients revealed that the diabetic group had considerably higher infection-related mortality. Conclusion:We found that CRKP infection was associated with higher resistance to antibiotics in the diabetic group. Furthermore, the diabetic group had a higher prevalence of carbapenemase-producing K. pneumoniae than the nondiabetic group. Crucially, in order to lower mortality without worsening antibiotic resistance and metabolic damage, more focus has to be placed on sensible and efficient antibiotic and supportive care therapies.

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Antibiotic sensitivity pattern of bacteria from diabetic foot infections Haji Adam Malik central general hospital

Cited by 2 publications

References 11 publications

Bacteriological Profile and Antibiotic Susceptibility Pattern of Diabetic Foot Infection in a Tertiary Care Hospital in Lampung, Indonesia

Bacteriological Profile and Antibiotic Susceptibility Pattern of Diabetic Foot Infection in a Tertiary Care Hospital in Lampung, Indonesia

Carbapenemase-Producing Klebsiella pneumoniae Infections in Diabetic and Nondiabetic Hospitalized Patients

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