Antibiotic resistomes in water supply reservoirs sediments of central China: main biotic drivers and distribution pattern

Zhang, Kai; Li, Kuangjia; Xu, Rui; Han, Yu; Guo, Ziwei; Zou, Wei; Wei, Wei; Cui, Xiangchao; Zhang, Zhongshuai; Zhang, Ying

doi:10.1007/s11356-021-18095-w

Cited by 9 publications

(3 citation statements)

References 64 publications

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“…Sediment samples from water reservoirs located in central China have revealed the presence of 174 ARGs, with multidrug, sulfonamide, and vancomycin ARGs being the most prevalent. MGEs are identified as the main biotic factors contributing to ARG dissemination in sediment [ 37 ]. Similarly, most borehole and tap water samples in Ghana show no E. coli counts, and over 50% show no detectable P. aeruginosa .…”

Section: Antibiotic Resistance (Abr) In Aquatic Environmentsmentioning

confidence: 99%

Unseen Weapons: Bacterial Extracellular Vesicles and the Spread of Antibiotic Resistance in Aquatic Environments

Barathan,

Ng,

Lokanathan

et al. 2024

IJMS

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This paper sheds light on the alarming issue of antibiotic resistance (ABR) in aquatic environments, exploring its detrimental effects on ecosystems and public health. It examines the multifaceted role of antibiotic use in aquaculture, agricultural runoff, and industrial waste in fostering the development and dissemination of resistant bacteria. The intricate interplay between various environmental factors, horizontal gene transfer, and bacterial extracellular vesicles (BEVs) in accelerating the spread of ABR is comprehensively discussed. Various BEVs carrying resistance genes like blaCTX-M, tetA, floR, and sul/I, as well as their contribution to the dominance of multidrug-resistant bacteria, are highlighted. The potential of BEVs as both a threat and a tool in combating ABR is explored, with promising strategies like targeted antimicrobial delivery systems and probiotic-derived EVs holding significant promise. This paper underscores the urgency of understanding the intricate interplay between BEVs and ABR in aquatic environments. By unraveling these unseen weapons, we pave the way for developing effective strategies to mitigate the spread of ABR, advocating for a multidisciplinary approach that includes stringent regulations, enhanced wastewater treatment, and the adoption of sustainable practices in aquaculture.

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Section: Antibiotic Resistance (Abr) In Aquatic Environmentsmentioning

confidence: 99%

Unseen Weapons: Bacterial Extracellular Vesicles and the Spread of Antibiotic Resistance in Aquatic Environments

Barathan,

Ng,

Lokanathan

et al. 2024

IJMS

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“…Hence, it is critically important that as the use of recycled irrigation water increases any microbiological water quality issues associated with the water are identified and remediated. Issues of potential concern include the possible persistence of bacterial, viral, and protozoan pathogens in recycled irrigation water that has not been adequately treated. − Moreover, there is concern that antibiotic resistance genes (ARGs) persisting in recycled irrigation water could augment environmental reservoirs of resistance and potentially contribute to the growing overall public health challenge of increasing rates of antibiotic-resistant bacterial infections. − …”

Section: Introductionmentioning

confidence: 99%

Variations in Bacterial Communities and Antibiotic Resistance Genes Across Diverse Recycled and Surface Water Irrigation Sources in the Mid-Atlantic and Southwest United States: A CONSERVE Two-Year Field Study

Malayil

Ramachandran

Chattopadhyay

et al. 2022

Environ. Sci. Technol.

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Reduced availability of agricultural water has spurred increased interest in using recycled irrigation water for U.S. food crop production. However, there are significant knowledge gaps concerning the microbiological quality of these water sources. To address these gaps, we used 16S rRNA gene and metagenomic sequencing to characterize taxonomic and functional variations (e.g., antimicrobial resistance) in bacterial communities across diverse recycled and surface water irrigation sources. We collected 1 L water samples (n = 410) between 2016 and 2018 from the Mid-Atlantic (12 sites) and Southwest (10 sites) U.S. Samples were filtered, and DNA was extracted. The V3–V4 regions of the 16S rRNA gene were then PCR amplified and sequenced. Metagenomic sequencing was also performed to characterize antibiotic, metal, and biocide resistance genes. Bacterial alpha and beta diversities were significantly different (p < 0.001) across water types and seasons. Pathogenic bacteria, such as Salmonella enterica, Staphylococcus aureus, and Aeromonas hydrophilia were observed across sample types. The most common antibiotic resistance genes identified coded against macrolides/lincosamides/streptogramins, aminoglycosides, rifampin and elfamycins, and their read counts fluctuated across seasons. We also observed multi-metal and multi-biocide resistance across all water types. To our knowledge, this is the most comprehensive longitudinal study to date of U.S. recycled water and surface water used for irrigation. Our findings improve understanding of the potential differences in the risk of exposure to bacterial pathogens and antibiotic resistance genes originating from diverse irrigation water sources across seasons and U.S. regions.

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“…Currently, ARGs have been regarded as an emerging pollutant [ 2 , 3 , 4 ]. The distribution characteristic and the level of ARGs pollution in the natural environment, such as rivers, lakes, reservoirs, marine, and even drinking water, have been widely studied [ 5 , 6 , 7 , 8 ]. The results showed that ARG pollution existed to different degrees in the environment.…”

Section: Introductionmentioning

confidence: 99%

The Sources and Potential Hosts Identification of Antibiotic Resistance Genes in the Yellow River, Revealed by Metagenomic Analysis

Zhang

Liu

et al. 2022

IJERPH

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The fate of antibiotic resistance genes (ARGs) has been revealed in various environmental media in recent years. Namely, the emergence of genes that resist colistin and carbapenems has attracted wide attention. However, the pollution condition of ARGs and sources in the Yellow River is still little understood, despite the river being the second longest in China. The present study determined the levels of ARG pollution in the Henan section of the Yellow River and evaluated the role of the aquaculture industry in the spread of ARGs. As revealed by the results, a total of 9 types of ARGs were detected in the sediments of the Yellow River, and the total ARG content in the Yellow River ranges from 7.27 to 245.45 RPKM. Sul1 and sul2 are the dominant ARGs, and the huge usage of sulfonamides, horizontal gene transfer, and wide bacteria host contribute to the prevalence of these two genes. The results of Spearman correlation analysis indicate that the breeding industry has little influence on ARGs in the Yellow River. Network analysis reveals that the opportunistic pathogen Pseudomonas is the potential host of sul1, tetG, and ANT(3′′)-IIa, which can pose a risk to human health.

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Antibiotic resistomes in water supply reservoirs sediments of central China: main biotic drivers and distribution pattern

Cited by 9 publications

References 64 publications

Unseen Weapons: Bacterial Extracellular Vesicles and the Spread of Antibiotic Resistance in Aquatic Environments

Unseen Weapons: Bacterial Extracellular Vesicles and the Spread of Antibiotic Resistance in Aquatic Environments

Variations in Bacterial Communities and Antibiotic Resistance Genes Across Diverse Recycled and Surface Water Irrigation Sources in the Mid-Atlantic and Southwest United States: A CONSERVE Two-Year Field Study

The Sources and Potential Hosts Identification of Antibiotic Resistance Genes in the Yellow River, Revealed by Metagenomic Analysis

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