Antibiotic-Resistant Gram-negative Bacteria Carriage in Healthcare Workers Working in an Intensive Care Unit

Duong, Bich Thuy; Duong, M.; Campbell, James; Nguyễn, Văn Minh; Nguyen, Huu Hien; Bui, Thi Bich Hanh; Nguyễn, Văn Vịnh; McLaws, Mary‐Louise

doi:10.3947/ic.2021.0040

Cited by 8 publications

(4 citation statements)

References 18 publications

(30 reference statements)

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“…Health-care workers (HCWs) represent a special population in the community that may have a significantly different colonization prevalence with MDR-Ent. For instance, the prevalence of HCWs colonized with 3GC-R-Ec was 4%, 12%, 24%, 47%, 65%, and > 75% in Germany (2013-2014), Italy (2016), Egypt (2013), Rwanda (2014), Vietnam (2019), and Madagascar (2014-2015), respectively [55,[128][129][130][131][132]. Nevertheless, such prevalence seems consistent to that recorded in the general population (see previous section).…”

Section: Health-care Workersmentioning

confidence: 56%

Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers

Campos-Madueno

Moradi

Eddoubaji

et al. 2023

Eur J Clin Microbiol Infect Dis

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The clinical impact of infections due to extended-spectrum β-lactamase (ESBL)- and/or carbapenemase-producing Enterobacterales (Ent) has reached dramatic levels worldwide. Infections due to these multidrug-resistant (MDR) pathogens—especially Escherichia coli and Klebsiella pneumoniae—may originate from a prior asymptomatic intestinal colonization that could also favor transmission to other subjects. It is therefore desirable that gut carriers are rapidly identified to try preventing both the occurrence of serious endogenous infections and potential transmission. Together with the infection prevention and control countermeasures, any strategy capable of effectively eradicating the MDR-Ent from the intestinal tract would be desirable. In this narrative review, we present a summary of the different aspects linked to the intestinal colonization due to MDR-Ent. In particular, culture- and molecular-based screening techniques to identify carriers, data on prevalence and risk factors in different populations, clinical impact, length of colonization, and contribution to transmission in various settings will be overviewed. We will also discuss the standard strategies (selective digestive decontamination, fecal microbiota transplant) and those still in development (bacteriophages, probiotics, microcins, and CRISPR-Cas-based) that might be used to decolonize MDR-Ent carriers.

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Section: Health-care Workersmentioning

confidence: 56%

Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers

Campos-Madueno

Moradi

Eddoubaji

et al. 2023

Eur J Clin Microbiol Infect Dis

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“… _ _ _ _ 1 [ 73 ] Klebsiella spp. 1 [ 33 ] 5 [ 35 , 36 , 38 , 114 , 115 ] _ _ 1 [ 73 ] ESBL-producing Klebsiella _ 2 [ 74 , 75 ] _ _ _ Proteus spp. _ 1 [ 36 ] _ _ _ ESBL-producing Proteus _ 1 [ 75 ] _ _ _ Shigella spp.…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of integrated studies on antimicrobial resistance in Vietnam, with a focus on Enterobacteriaceae, from a One Health perspective

et al. 2022

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“…Because the rectal area has more pathogens than the hands and nose, in comparison to the current study, so there may be a lower percentage of gram-negative organisms. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Surveillance of bacterial carriage in the nose and hands of healthcare workers and patients attending maternity and children's hospital

Mitra,

Pachpute

2023

Journal of Family Medicine and Primary Care

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Introduction: Nosocomial infections have been acknowledged as a significant pathogen responsible for human illness due to the rise in the incidence of these infections that are mainly caused by resistant strains. As a result, it is important to prevent nosocomial infections. Therefore, in the epidemiology and pathogenesis of infection bacterial carriage appears to be of great importance and in healthy persons, three patterns of carriage are observed over time. The common ecological niches of microorganisms are the anterior nares and hands; hence, the present study aims to evaluate the surveillance of bacterial carriage from the hands and noses of healthcare workers that involve doctors, nurses, and housekeeping staffs and patients involving pregnant women or mothers. Materials and Methods: An observational prospective study was conducted for 1.5 years in which collection of swabs from both the hands and nose were taken and inoculated on mannitol salt agar, blood agar, and MacConkey agar and incubated at 37°C for 24 h following which biochemical reactions were performed from isolates and 160 nasal swabs and hand swabs were studied for bacterial growth. Results: The percentages of bacterial growth in the hands of mothers, doctors, housekeeping staff, and nurses were 17.5, 12.5, 52.5, and 25%, respectively, and in the nose were 7.5, 5, 32.5, and 12.5%, respectively. Total bacterial carriage in hand and nose swabs were 26.87 and 14.37%, respectively. Conclusion: Methicillin-resistant Staphylococcus aureus was the most common microorganism isolated and as a result to prevent its spread along with other nosocomial microorganisms, appropriate precautions should be taken as the spreading of these organisms can lead to drug resistance strains.

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Antibiotic-Resistant Gram-negative Bacteria Carriage in Healthcare Workers Working in an Intensive Care Unit

Cited by 8 publications

References 18 publications

Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers

Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers

A systematic review and meta-analysis of integrated studies on antimicrobial resistance in Vietnam, with a focus on Enterobacteriaceae, from a One Health perspective

Surveillance of bacterial carriage in the nose and hands of healthcare workers and patients attending maternity and children's hospital

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