Antibiotic resistant biofilms and the quest for novel therapeutic strategies

Abstract

Antimicrobial resistance (AMR) is one of the major leading causes of death around the globe. Present treatment pipelines are insufficient to overcome the critical situation. Prominent biofilm forming human pathogens which have the ability to thrive in infection sites using adaptive features results in biofilm persistence. This is a challenge due to involvement of unknown pathways for which therapeutic targets are still unknown. In regard to this developing newer and effective treatment options using edge cutting technologies in medical research is the need of time. The reasons underlying the adaptive features in biofilm persistence have been centred on different metabolic and physiological aspects. The high tolerance levels against antibiotics direct researchers to search for novel bioactive molecules that can help combat the problem. In view of this, the present review outlines the focuses on a possible opportunity of different strategies which are in testing pipeline can thus be developed into products ready to use.