Antibiotic-resistant acne: lessons from Europe

Ross, J I; Snelling, Anna M.; Carnegie, Ellen; Coates, Paul M.; Cunliffe, W.J.; Bettoli, Vincenzo; Tosti, Giulio; Katsambas, Andreas; Pulgar, José Ignacio Galvañ Pérez del; Rollman, Ola; Török, László; Eady, E. Anne; Cove, Jonathan H.

doi:10.1046/j.1365-2133.2003.05067.x

Cited by 311 publications

(344 citation statements)

References 14 publications

(30 reference statements)

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“…The same molecular mechanisms may explain the activity of PMAs in part; however, the basis of this effect by PMAs remains unclear. In addition, the selected PMAs were also highly active (MIC ≤ 2 µg/mL) against anaerobic bacteria P. acnes which is a major etiological agent of acne vulgaris; increasing resistance of this bacteria to standard antibiotic therapies reduces the efficacy of therapeutic agents and often leads to failure of dermatological treatment [50,51]. As a first assessment of polymer toxicity, we evaluated the hemolytic activity of PMAs against human red blood cells (RBCs).…”

Section: Activity Spectrummentioning

confidence: 99%

Activity and Mechanism of Antimicrobial Peptide-Mimetic Amphiphilic Polymethacrylate Derivatives

et al. 2011

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Cationic amphiphilic polymethacrylate derivatives (PMAs) have shown potential as a novel class of synthetic antimicrobials. A panel of PMAs with varied ratios of hydrophobic and cationic side chains were synthesized and tested for antimicrobial activity and mechanism of action. The PMAs are shown to be active against a panel of pathogenic bacteria, including a drug-resistant Staphylococcus aureus, compared to the natural antimicrobial peptide magainin which did not display any activity against the same strain. The selected PMAs with 47-63% of methyl groups in the side chains showed minimum inhibitory concentrations of ≤2-31 µg/mL, but cause only minimal harm to human red blood cells. The PMAs also exhibit rapid bactericidal kinetics. Culturing Escherichia coli in the presence of the PMAs did not exhibit any potential to develop resistance against the PMAs. The antibacterial activities of PMAs against E. coli and S. aureus were slightly reduced in the presence of physiological salts. The activity of PMAs showed bactericidal effects against E. coli and S. aureus in both exponential and stationary growth phases. These results demonstrate that PMAs are a new antimicrobial platform with no observed development of resistance in bacteria. In addition, the PMAs permeabilized the E. coli outer membrane at polymer concentrations lower than their MIC values, but they did not show any effect on the bacterial inner membrane. This indicates that mechanisms other than membrane permeabilization may be the primary factors determining their antimicrobial activity.

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Section: Activity Spectrummentioning

confidence: 99%

Activity and Mechanism of Antimicrobial Peptide-Mimetic Amphiphilic Polymethacrylate Derivatives

et al. 2011

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“…АӨСҮТ-ийн лабораториор 2016 оны 10 сараас 2017 оны 3 сар хүртлэх хугацаанд үйлчлүүлсэн 40 хүнээс судалгааны асуумж [2,3] бөглүүлэн батганы дээжийг тосны булчирхайн шүүрлийг шахах аргаар авлаа [8]. Батганы дээжийг зориулалтын материалаар авч (Hiculture transport swab, Himedia, India) 24 цагийн дотор шинжилсэн болно.…”

Section: материал арга зүйunclassified

Монгол Хүний Батга Үүсгэгч, Эмгэгшүүлэгчийг Тодорхойлсон Дүн

Оюунбилэг¹,

Энхцацрал²,

Болортуяа³

et al. 2017

Proc. Mong. Acad. Sci.

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“…The clinical improvement is not, however, because clindamycin and/or erythromycin are antibacterial, because antibacterial resistance to these agents are reported to be as high as 94% in 2003 [15]. The reason for the combination giving improved therapeutics is that clindamycin and erythromycin are both chemically tertiary amines.…”

Section: Benzoyl Peroxide With Alterations As the Preferred Topicalmentioning

confidence: 99%

A Patient-Oriented Approach to Acne, Rosacea, Perioral Dermatitis, and Isotretinoin with Working Patient Informational/Instructional Sheets and a Review of Pathophysiology and Mechanisms of Therapeutic Agents

Burkhart¹

2008

TODJ

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Patient informational/instructional sheets can be used not only to assist in providing patients with baseline material regarding their condition, but also aid in physicians communicating a treatment protocol. Educational material regarding acne, adult acne, perioral dermatitis, and isotretinoin is included for perusal and discussion. Within this framework, one learns the unifying concept of the Propionibacterium acnes biofilm, methods to maximize production of benzoyl peroxide radicals (the active biological form of this compound), unplugging ability of oral antibiotics, and low-dose isotretinoin therapeutics.

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Antibiotic-resistant acne: lessons from Europe

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Cited by 311 publications

References 14 publications

Activity and Mechanism of Antimicrobial Peptide-Mimetic Amphiphilic Polymethacrylate Derivatives

Activity and Mechanism of Antimicrobial Peptide-Mimetic Amphiphilic Polymethacrylate Derivatives

Монгол Хүний Батга Үүсгэгч, Эмгэгшүүлэгчийг Тодорхойлсон Дүн

A Patient-Oriented Approach to Acne, Rosacea, Perioral Dermatitis, and Isotretinoin with Working Patient Informational/Instructional Sheets and a Review of Pathophysiology and Mechanisms of Therapeutic Agents

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