Antibiotic resistance spread potential in urban wastewater effluents disinfected by UV/H2O2 process

Ferro, Giovanna; Guarino, Francesco; Castiglione, Stefano; Rizzo, Luigi

doi:10.1016/j.scitotenv.2016.04.047

Cited by 134 publications

(46 citation statements)

References 32 publications

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“…Municipal wastewater treatment plants. Urban wastewater treatment plants (UWWTPs) are one of the most concerned sources of AR spread into the environment due to higher cellular density and contamination with both antibiotics and bacteria (Ferro et al, 2016). Production of sewage sludge is a major by-product of municipal wastewater treatment process (Bondarczuk et al, 2016).…”

Section: Occurrence Of Amr In the Environmentmentioning

confidence: 99%

“…The fate of ARGs and other intracellular material after the disruption of bacterial cells in the disinfection process often goes unaddressed. AR spread into the environment and their control by the UV/H2O2 disinfection process was investigated(Ferro et al, 2016). The total coliforms including resistant E. coli were significantly inactivated after disinfection, but many resistant genes (blaTEM, qnrS, and tetW) were present even after 4 hr of disinfection treatment.…”

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confidence: 99%

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Antimicrobial Resistance in the Environment

Waseem

Williams

Stedtfeld

et al. 2017

Water Environment Research

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This review summarizes selected publications of 2016 with emphasis on occurrence and treatment of antibiotic resistance genes and bacteria in the aquatic environment and wastewater and drinking water treatment plants. The review is conducted with emphasis on fate, modeling, risk assessment and data analysis methodologies for characterizing abundance. After providing a brief introduction, the review is divided into the following four sections: i) Occurrence of AMR in the Environment, ii) Treatment Technologies for AMR, iii) Modeling of Fate, Risk, and Environmental Impact of AMR, and iv) ARG Databases and Pipelines.

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Section: Occurrence Of Amr In the Environmentmentioning

confidence: 99%

mentioning

confidence: 99%

Antimicrobial Resistance in the Environment

Waseem

Williams

Stedtfeld

et al. 2017

Water Environment Research

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“…Among other emerging health threats on the global scale, spreading of antibiotic-resistant genes (ARG), often hosted in common pathogen microorganisms such as Escherichia Coli, has become an urgent health issue as well as a threat to economic stability (Ferro et al, 2016).…”

Section: Healthier Diets Mattermentioning

confidence: 99%

Innovative beer-brewing of typical, old and healthy wheat varieties to boost their spreading

Albanese

Ciriminna

Meneguzzo

et al. 2017

Preprint

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Certain typical old wheat varieties grown in the Mediterranean countries and elsewhere are renowned for their nutritional value due to higher concentration of polyphenols, especially flavonoids, as well as of important minerals, than modern varieties. However, the respective economical sustainability is constrained by reduced yield, increasing costs and stagnating or decreasing market prices. Moreover, under certain conditions, connected with the respective scale and local market volume, low-input, organically grown cereals can lead to lower environmental footprint. Brewing with a portion of such old grains can effectively boost their spreading, conditioned on its ability to supply a significant additional net income to farmers. Beer has become the worldwide most consumed alcoholic beverage and, although its market is dominated by few global players and standardized products, craft breweries have quickly spread out in most countries. Nevertheless, a scale issue has arisen about the economic sustainability of microbreweries, mainly due to high initial capital investment, energy costs, scale, and sometimes taxation. It is shown how breakthrough, cheaper, more efficient and profitable microbreweries can help solving the sustainability issues affecting old wheat varieties, thus boosting the respective spreading, lowering the environmental footprint of the cereal sector and contributing to improve the public health.

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“…Currently, antibiotic resistance presents an increasing trend that leads to significant public health issues and the increase in healthcare-associated infections caused by antibiotic-resistant pathogens worldwide (4,5). Resistance to different antimicrobial drugs is attributed to the increased irregular employment of antibiotics that have resulted in the drug resistance of expression of virulence factors, promotion of intra-hospital cross infection and even increased challenges of clinical treatments (6)(7)(8). A previous report suggests that the major driving force for the occurrence of antibiotic-resistant pathogens is the evolution of metabolic function caused by the rapid antibiotic consumption worldwide (9).…”

Section: Introductionmentioning

confidence: 99%

Klebsiella pneumoniae presents antimicrobial drug resistance for β‑lactam through the ESBL/PBP signaling pathway

et al. 2020

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Overuse and misuse of antibiotics leads to antibiotic resistance which has become a significant public health concern. Klebsiella pneumoniae is the most common pathogenic bacteria underlying nosocomial infections due to the expression of virulence factors and occurrence of antibiotic resistance. Evidence indicates that β-lactamase is involved in the antibiotic resistance of Klebsiella pneumoniae to β-lactam antibiotics. The aim of the present study was to investigate the association between the molecular biological mechanisms of antibiotic resistance of Klebsiella pneumoniae and extended-spectrum β-lactamase (ESBL). In order to assess temporal trends in prevalence and antimicrobial susceptibility, Klebsiella pneumoniae bacteria were isolated and the ESBL expression level was analyzed. Susceptibility tests were performed using automated systems. The β-lactam-resistance in Klebsiella pneumoniae was assessed by the β-lactam agar screen plate and respective MIC values were evaluated using E-test strips. The confirmatory disk diffusion methods were applied for phenotypic identification of the ESBL production of Klebsiella pneumoniae. The results showed that Klebsiella pneumoniae bacteria exhibited higher ESBL production after treatment with β-lactam compared to the control. The ESBL gene expression was upregulated in Klebsiella pneumoniae after treatment with β-lactam. Results identified that penicillin-binding proteins (PBPs) were associated with the growth and resistance to β-lactams. Zinc finger nuclease markedly inhibited the antibiotic resistance of Klebsiella pneumoniae to β-lactam. PBP knockdown abolished the inhibitory effects of zinc finger nuclease on the growth of Klebsiella pneumoniae induced by β-lactam antibiotic treatment. In conclusion, these results suggest that the resistance of Klebsiella pneumoniae bacteria to antimicrobial drugs is through the ESBL signaling pathway, which indicates that ESBL may be a potential target for abolishing resistance to β-lactam.

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Antibiotic resistance spread potential in urban wastewater effluents disinfected by UV/H2O2 process

Cited by 134 publications

References 32 publications

Antimicrobial Resistance in the Environment

Antimicrobial Resistance in the Environment

Innovative beer-brewing of typical, old and healthy wheat varieties to boost their spreading

Klebsiella pneumoniae presents antimicrobial drug resistance for β‑lactam through the ESBL/PBP signaling pathway

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