Antibiotic resistance rates of Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae isolated from a university-affiliated hospital in North Cyprus

Ruh, Emrah; Gazi, Umut; Güvenir, Meryem; Süer, Kaya; Çakir, Nedim

doi:10.5505/turkhijyen.2016.82653

Cited by 6 publications

(4 citation statements)

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“…Reduced carbapenem susceptibility among CIRE ( n = 6/500; 1.2%) isolates was mostly detected against ERT (resistant = 2/6, intermediate = 4/6, susceptible = 0/6), while number of the isolates that were susceptible to IMP (resistant = 1/6, intermediate = 1/6, susceptible = 4/6) and MEM (resistant = 1/6, intermediate = 0/6, susceptible = 5/6) was higher. This result is compatible with a previous report from Northern Cyprus where the resistance rate of ERT (4.6%) was higher than those of IMP (0.0%) and MEM (1.0%) in K. pneumoniae isolates [24].…”

Section: Discussionsupporting

confidence: 93%

“…Indeed, longer hospital stay was shown to be a risk factor for fecal carriage of CRE [20]. Furthermore, carbapenem resistance in K. pneumoniae isolates was documented at low levels previously in Northern Cyprus [24]. Taken together, all these evidence can explain the low CRE and CIRE colonization rates in the present study.…”

Section: Discussionsupporting

confidence: 70%

“…Another hospital-based study in Northern Cyprus documented the rate of ESBL to be 16.7% in Klebsiella pneumoniae isolates. Moreover, FQ resistance was reported between 16.8 and 20.1%, whereas IMP, MEM and ERT resistance rates were found to be 0.0, 1.0, and 4.6%, respectively, among K. pneumoniae isolates [24].…”

Section: Introductionmentioning

confidence: 99%

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Extended-spectrum β-lactamase, plasmid-mediated AmpC β-lactamase, fluoroquinolone resistance, and decreased susceptibility to carbapenems in Enterobacteriaceae: fecal carriage rates and associated risk factors in the community of Northern Cyprus

Ruh

Zakka

Hoti

et al. 2019

Antimicrob Resist Infect Control

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Background Antibiotic-resistant Enterobacteriaceae in the gastrointestinal flora can lead to infections with limited therapeutic options. Also, the resistant bacteria can be transferred from colonized persons to others. The present study was conducted to search the fecal carriage rates of (i) Enterobacteriaceae that produce extended-spectrum β-lactamase (ESBL-E) and/or (ii) plasmid-mediated AmpC β-lactamase (pAmpC-E), (iii) ciprofloxacin-resistant Enterobacteriaceae (CIP-RE), and (iv) carbapenem-intermediate or -resistant Enterobacteriaceae (CIRE) in Northern Cyprus. Methods A total of 500 community-dwellers were recruited from consecutive admissions to the clinical laboratories of four hospitals. One rectal swab or stool sample was collected from each participant. A questionnaire was applied to evaluate possible risk factors associated with intestinal colonization of resistant bacteria. The samples were cultured on antibiotic containing media to screen for resistant bacteria colonization. The bacterial colonies that grew on the plates were subjected to further phenotypic tests to confirm the resistance. Results Of 500 volunteers, ESBL-E, pAmpC-E, CIP-RE and CIRE carriage were detected in 107 (21.4%), 15 (3.0%), 51 (10.2%) and six (1.2%) participants, respectively. Escherichia coli was the most commonly recovered species among Enterobacteriaceae isolates. A significant proportion of ESBL-producing E. coli isolates ( n = 22/107; 20.6%) was found to be co-resistant to CIP ( p = 0.000, OR 3.21, 95% CI 1.76–5.87). In this study, higher socioeconomic status (CIP-RE: p = 0.024, OR 1.96, 95% CI 1.09–3.53), presence of gastrointestinal symptoms (CIRE: p = 0.033; OR 6.79, 95% CI 1.34–34.39), antibiotic use (ESBL-E: p = 0.031; OR 1.67, 95% CI 1.04–2.67; and CIRE: p = 0.033; OR 6.40, 95% CI 1.16–35.39), and travelling abroad (pAmpC-E: p = 0.010; OR 4.12, 95% CI 1.45–11.66) were indentified as risk factors. Conclusion The study indicates that resistant Enterobacteriaceae isolates are carried by humans in the community. To prevent further spread of resistance, rational use of antibiotics should be encouraged, and antibiotic resistance should be carefully monitored in Northern Cyprus.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 70%

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Extended-spectrum β-lactamase, plasmid-mediated AmpC β-lactamase, fluoroquinolone resistance, and decreased susceptibility to carbapenems in Enterobacteriaceae: fecal carriage rates and associated risk factors in the community of Northern Cyprus

Ruh

Zakka

Hoti

et al. 2019

Antimicrob Resist Infect Control

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“…CRPa was highly resistant to the carbapenems at an average of 41% with no trends (P > 0.05), our rateswere higher than some hospitals in our region. A recent published work from Jordan demonstrated that P. aruginosa isolated from clinical respiratory specimens expressed multiple resistant genes with 52.5% MDR phenotype [11,12], but lower than other countries where CRPa rate was as high as 90% [13]. The resistance for the traditional antipseudomonal β-lactamsin in this study was 35%, meanwhile, it ranged 15-23% elsewhere [14].…”

Section: Discussionmentioning

confidence: 42%

A Ten Years Study of The Rates and Resistance Trends of the ESKAPE Bacteria Isolated from Sterile Body Sites (2010 – 2019) at a Single Hospital

Ramahi¹,

Jamal²

2020

int. arab. j antimicrob. agents

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Background To assess the rates and trends of resistance among ESKAPE pathogens during 2010 – 2019. Methods A retrospective, single-center study between 2010 –2019, non-duplicate isolates from six sterile sources were studied. Pathogens were processed through the automated VITEK-2. The Clinical Laboratory Standards Institute (CLSI) breakpoints were referenced. The aim was to detect the rates and resistance trends of the ESKAPE pathogens, the rates of ESBL-producing K. pneumoniae, and the carbapenem-resistant (CR)-K. pneumoniae, CRAb, CRPa, VRE, and MRSA for the inpatients. Trends for the prevalence and resistance rates were analyzed by linear regression. Missing values were averaged based on the neighboring values. Data analysis was by SPSS version 25, and statistical significance is considered for one-tailed P < 0.05. Results The ESKAPE bacteria (4286 isolate) comprised (45.57%) of the inpatients' isolates, the sterile sources consisted of 1421 (33.15%): K. pneumonia 272 isolates, the ESBL-producing K. pneumoniae significantly declined (Pearson R - 0.877, P = 0.001), CR-K. pneumoniae showed no significant trends (P = 0.475). P. aeruginosa 202 isolates; resistance to carbapenem (CRPa) averaged 42%. S. aureus 198 isolates; MRSA rates averaged 45%. A. baumannii 165 isolates; carbapenem-resistance (CRAb) average 93%. Vancomycin-resistant (VR)E. Faecium = 33%, and VRE. faecalis = 15% with a weighted average 17%. Enterobacter spp. resistance rates were: Amikacin 3.6%, Third and fourth generation cephalosporines 28% and 20% respectively, Quinolones 27% ± 3%, Piperacillin/tazobactam resistance 29%, Imipenem 15%, and Meropenem 27. Conclusion The ESKAPE pathogens were highly resistant, making treatment more complicated, and compromise the initial empiric treatment.

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Bacterial Antibiotic Resistance: on the Cusp of a Post-antibiotic World

Sprigg

Pietrangeli

2019

Curr Treat Options Infect Dis

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Antibiotic resistance rates of Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae isolated from a university-affiliated hospital in North Cyprus

Cited by 6 publications

References 9 publications

Extended-spectrum β-lactamase, plasmid-mediated AmpC β-lactamase, fluoroquinolone resistance, and decreased susceptibility to carbapenems in Enterobacteriaceae: fecal carriage rates and associated risk factors in the community of Northern Cyprus

Extended-spectrum β-lactamase, plasmid-mediated AmpC β-lactamase, fluoroquinolone resistance, and decreased susceptibility to carbapenems in Enterobacteriaceae: fecal carriage rates and associated risk factors in the community of Northern Cyprus

A Ten Years Study of The Rates and Resistance Trends of the ESKAPE Bacteria Isolated from Sterile Body Sites (2010 – 2019) at a Single Hospital

Bacterial Antibiotic Resistance: on the Cusp of a Post-antibiotic World

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