Antibiotic Resistance Profile of Clinical Strains of Enterococci from Secondary/Persistent Endodontic Infections: What do We Know? A Systematic Review of Clinical Studies

Barbosa-Ribeiro, Marlos; Gomes, Brenda P.F.A.; Arruda-Vasconcelos, Rodrigo; Monteiro, Igor de Albuquerque; Costa, Moan Jéfter Fernandes; Sette-de-Souza, Pedro Henrique

doi:10.1016/j.joen.2023.12.007

Cited by 2 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They demonstrated 40 STs, of which 23 STs contained only one isolate, and clones of ST21 ST40, ST30 and ST56. Pinheiro et al [12] also found clones belonging to ST 25, ST 62, ST 79 and ST 396 in endodontic E. faecalis, in which 42.8% were assigned to the same clonal complex (CC25). This complex includes ST 97, also found in our collection (n=3).…”

Section: Discussionmentioning

confidence: 96%

“…Regarding ST 397, it has only been reported in Brazil and was the main ST associated with our isolates in both sampling years (2010 and 2020), demonstrating its persistence over the years in Brazilian endodontic infections. The initial recorded case of ST 397 in a patient with an endodontic infection was in the state of São Paulo in 2003 [12,15]. This suggests that ST 397 has been present in the southeastern region of Brazil for at least 17 years and could potentially infect root canals of unrelated patients.…”

Section: Discussionmentioning

confidence: 99%

“…According to Barbosa-Ribeiro et al [12], there has been an increase in the resistance pro le of E faecalis to vancomycin, chloramphenicol, gentamicin, metronidazole, moxi oxacin, tigecycline in recent years. However, resistance to vancomycin was not observed in our collection.…”

Section: Discussionmentioning

confidence: 99%

“…Another concern regarding E. faecalis is its antimicrobial resistance. Ardilla et al [11]; 2022, reviewed antimicrobial resistance in endodontic infection and Barbosa-Ribeiro et al [12], 2024, in endodontic enterococci. Both reports expressed alarm at the increasing antimicrobial resistance of endodontic E. faecalis over time.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diversity in endodontic Enterococcus faecalis from Brazil with high occurrence of ST 397 clone

LINS,

FREITAS,

VICENTE

2024

Preprint

View full text Add to dashboard Cite

Objectives: The aim of this study was to assess the genetic relatedness of E. faecalis strains from primary endodontic infections in Brazil, test the hypothesis of clones infecting unrelated individuals, and examine the antimicrobial resistance profile. Materials and Methods: The genetic relationship of 32 endodontic E. faecalis were investigated by multilocus sequecing typing (MLST). These isolates were collected from unrelated patients with primary endodontic infection treated in Brazil between 2010 and 2023. Antimicrobial susceptibility testing was performed using the disk diffusion technique according to the Clinical Laboratory Standard Institute. Results: 12 sequence types (STs) were detected, of which 8 STs contained only one strain. We found clones of ST 30, ST40, ST 97 and ST 397, with a high frequency of the latter (15/32). Susceptibility to the antimicrobial agents tested varied, with the highest percentage of resistance observed for clindamycin (100%), tetracycline (34.4%), azithromycin (31.2%) and ciprofloxacin (19.2%). One isolate was multidrug resistant. Conclusions: MLST of endodontic E. faecalis showed clones infecting different individuals in different cities up to 10 years apart with high occurrence of ST 397. This data, together with the literature, raise the concern that there may be clones specialized in endodontic infections. Further MLST studies are needed, as well as surveillance for antimicrobial resistance in endodontic isolates. Clinical Relevance: Enterococcus faecalis is a common cause of nosocomial infections and is frequently associated with root canal infections. The identification of clones specialized in endodontic infections may lead to more effective therapeutic strategies.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations