Antibiotic resistance pattern of uropathogens in urinary tract infections in children at State Referral Hospital, Falkawn, Mizoram, India

Lalhmangaihzuali, F. Elizabeth; Zarzoliana,; Varte, Zorinsangi; Laldinmawii, Gracy

doi:10.18203/2349-3291.ijcp20184182

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…This is a rather alarming finding for the northeastern region of India because it indicates faster dissemination of antibiotic resistance genes had occurred among the bacterial population. A study conducted by the state referral hospital in Falkawn, Mizoram, showed the emergence of a large number of MDR strains in this region [10]. Our study, which focused on two areas, Lunglei and Aizawl, found a high incidence of antibiotic resistance in Gram-negative bacteria to the last-resort antibiotics carbapenem, colistin and tigecycline.…”

Section: Discussionmentioning

confidence: 48%

“…In the northeast regions, in the states of Mizoram, Tripura, Nagaland and Meghalaya, the prevalence of carbapenem resistance were found to be below 5% due to less developed healthcare and the comparably reduced amounts of carbapenems used in these regions [10]. Based on this information, this study was conducted to assess the emergence of Gramnegative bacteria in Mizoram that are carbapenem-resistant, as well as to detect the presence of carbapenemase genes in the clinical isolates collected from two hospitals in the region.…”

Section: Introductionmentioning

confidence: 99%

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The Emergence of Carbapenem-Resistant Gram-Negative Bacteria in Mizoram, Northeast India

Vanlalruati¹,

Loganathan

Manohar

et al. 2022

Microbiology Research

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(Background) Numerous reports on carbapenem resistance in different parts of India have been published, yet there are insufficient studies on the prevalence of antibiotic resistance in the northeast region of the country. This study evaluated the emergence of carbapenem resistance in the clinical isolates collected in Mizoram. (Results) A total of 141 Gram-negative clinical isolates were collected from the two hospitals, including the Civil Hospital in Lunglei and the Synod Hospital in Aizawl. The isolates include Escherichia coli (n = 62, 43.9%), Klebsiella spp. (n = 43, 30.4%), Pseudomonas aeruginosa (n = 9, 6.3%), Serratia marcescens (n = 3, 2.1%), Proteus mirabilis (n = 2, 1.4%), Shigella spp. (n = 4, 2.8%), Enterobacter spp. (n = 6, 4.2%) and Acinetobacter spp. (n = 12, 8.5%). The isolates were found to be resistant to meropenem (11%), colistin (48%), tigecycline (25%) and cefotaxime (50%). A total of four E. coli and one Shigella sonnei encoded the blaOXA-48-like gene. The blaCTX-M-1 gene was detected in 13 isolates, of which eight were E. coli, two Shigella flexneri, and one isolates each of K. pneumoniae, K. oxytoca and Shigella sonnei, respectively. (Conclusion) Carbapenem-resistant Enterobacteriaceae are common among other parts of India, despite limited access to antibiotics, the emergence of resistance in the northeastern region is worrying.

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

The Emergence of Carbapenem-Resistant Gram-Negative Bacteria in Mizoram, Northeast India

Vanlalruati¹,

Loganathan

Manohar

et al. 2022

Microbiology Research

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“…or ampicillin 1-2 g orally or i.v. (especially infection due to enterobacter) or a cephalosporin (19). Follow up urine culture is recommended after 2 weeks of therapy.…”

Section: Treatment Of Upper Utimentioning

confidence: 99%

Current therapies of urinary tract infections and prevention of multi drug resistance

Balusupati,

Sura,

Pinneboina

et al. 2024

Int J Curr Innov Adv Res

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Urinary Tract Infections are very severe public health problem and are caused by Escherichia coli, Klebsiella, Proteus, Enterococcus, Pseudomonas, Acinetobacter, Citrobacter and Staphylococcus etc. . Recurrent UTIs and multi drug resistance causes increasing in the economic burden. In this review article we discuss about the pathogens causing UTI, prevalence, current treatment options, multi drug resistance and it’s prevention. For prophylactic management in recurrent UTIs, there are no standard and uniform guidelines . Over use and misuse of the antibiotics leads to drug resistance in the patients. Mostly clinicians use empirical or targeted anti infective agents in the prevention and treatment of UTI along with long term low dose prophylactic antibiotics. However against the growing drug resistance within the uropatgogens, alternative non antibiotic strategies like immuno prophylaxis, estrogen replacement in women are becoming an extremely attractive and reasonable solution in reducing the resistance.

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Trends in Antimicrobial Resistance in a Tertiary Care Hospital of Assam, India

Das¹,

Nath²,

Choudhury³

et al. 2023

J. Pure Appl. Microbiol.

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Antimicrobial resistance (AMR) in bacterial pathogens has emerged as a challenge in health care settings resulting in high rates of morbidity and mortality. The aim of the present study was to describe the trends and burden of AMR in a tertiary care hospital. A retrospective observational study was undertaken from October 2018 to March 2021 in a clinical microbiology laboratory where local priority pathogens and their antimicrobial resistance patterns were analyzed. Organism identification and antimicrobial susceptibility testing were performed as per Clinical and Laboratory Standards Institute guidelines. Out of 9948 isolates, Enterobacteriaceae (58%) were mostly isolated followed by Staphylococci (18.6%), Non-fermenting gram negative bacilli (NFGNB) (13.7%), and Enterococci (8.4%) respectively. Highest isolation was from inpatient department (61.3%); 31.5% from outpatient, and 7.2 % from intensive care units. Klebsiella pneumoniae (26.9%) was most isolated organism, mostly from respiratory samples; Escherichia coli was isolated mostly from urine (40.7%). Almost half of the Enterobacteriaceae isolates were extended spectrum beta-lactamase producers while >50% of Enterobacteriaceae and NFGNB isolates were resistant to one or more Carbapenems. Frequency of Methicillin resistant Staphylococcus aureus was 44.7% , Vancomycin resistant Enterococci was 1.2%. A rising trend of resistance to cephalosporins and carbapenems along with fluoroquinolones was observed. Our study has witnessed a high prevalence of Gram negative pathogens with increasing resistance to commonly applied antimicrobials during the surveillance period which can act as a guiding tool in devising local antimicrobial priorities, antibiotic policy, and proper antimicrobial prescribing practices.

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Antibiotic resistance pattern of uropathogens in urinary tract infections in children at State Referral Hospital, Falkawn, Mizoram, India

Cited by 5 publications

References 16 publications

The Emergence of Carbapenem-Resistant Gram-Negative Bacteria in Mizoram, Northeast India

The Emergence of Carbapenem-Resistant Gram-Negative Bacteria in Mizoram, Northeast India

Current therapies of urinary tract infections and prevention of multi drug resistance

Trends in Antimicrobial Resistance in a Tertiary Care Hospital of Assam, India

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