Antibiotic Resistance in the Uropathogenic Enterobacteria Isolated from Patients Attending General Reference Hospital (GRH) of Niamey, Niger

Mohamed, Alassane Halawen; Dembélé, René; Salaou, Chaibou; Kagambèga, Alix Bénédicte; Coulibaly, Hiliassa; Bado, Frédéric François; Fody, Alio Mahamadou; Boubou, Laouali; Alkassoum, Ibrahim; Omar, Eric Adehossi; Holzinger, Mauricio Arcos; Barro, Nicolas

doi:10.4236/ojmm.2023.131007

Cited by 1 publication

(1 citation statement)

References 40 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitek GN cards were used to identify E. coli isolates and an AST-N372 card was used to determine the E. coli isolates' sensitivity and resistance to fosfomycin [19]. Each AST card contains a selection of antibiotics in varying concentrations, together with a dehydrated culture medium.…”

Section: Identification and Antimicrobial Susceptibility Testingmentioning

confidence: 99%

Efficacy of Fosfomycin against Extended Spectrum Beta-Lactamase-Producing Escherichia coli Isolated from Patient Urinary Cultures in the General Reference Hospital of Niamey, Niger

Mohamed,

Dembélé,

Fody

et al. 2023

Uro

Self Cite

View full text Add to dashboard Cite

Urinary tract infection (UTI) is a common patient infection and a major public health problem today. The rapid spread of antibiotic resistance genes in Enterobacterales, particularly in Extended-spectrum beta-lactamases producing Escherichia coli (ESBL-E. coli), is compromising treatment with the antibiotics that are normally used. The aim of this study was to evaluate the level of susceptibility of uropathogenic ESBL-producing E. coli to fosfomycin as an alternative treatment. A total of 3369 samples of urine were received and processed in the Bacteriology Laboratory of the Niamey General Reference Hospital (NGRH) throughout 2021. Synergy testing was performed for phenotypic detection of ESBLs, and fosfomycin sensibility of ESBLs-producing uropathogenic E. coli isolates were determined using the Viteck-2 system. Of the 280 enterobacteria identified in the urine samples, 104 Escherichia coli isolates were positive to the synergy test. The average age of the patients was 54 ± 17. The age range of 46–65 years was the most affected by these infections. The female patients predominated over the male ones, with a prevalence of 51.90%, a sex ratio of 1.08. The ESBL-producing E. coli isolates were 0.97% resistant to fosfomycin. Fosfomycin is highly effective against uropathogenic ESBL-producing E. coli isolates. It could be used as an alternative treatment for both uncomplicated and complicated urinary tract infections.

show abstract

Section: Identification and Antimicrobial Susceptibility Testingmentioning

confidence: 99%