Antibiotic Resistance in Neisseria

Bash, Margaret C.; Matthias, Kathryn

doi:10.1007/978-3-319-47266-9_6

Cited by 17 publications

(6 citation statements)

References 203 publications

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“…We were unable to find a systematic review on the topic. In addition to the studies noted above, we found studies where the mean concentration of ciprofloxacin in chicken meat was 6.3 μg/kg (Lebanon) and 31 μg/kg (Turkey) and, in goat’s milk, was 100 mcg/L (Spain) [ 1 , 2 , 3 ].…”

Section: Discussionmentioning

confidence: 76%

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Ciprofloxacin Concentrations 1/1000th the MIC Can Select for Antimicrobial Resistance in N. gonorrhoeae—Important Implications for Maximum Residue Limits in Food

et al. 2022

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Background: Concentrations of fluoroquinolones up to 200-fold lower than the minimal inhibitory concentration (MIC) have been shown to be able to select for antimicrobial resistance in E. coli and Salmonella spp. (the minimum selection concentration—MSC). We hypothesized that the low concentrations of quinolones found in meat may play a role in the genesis of quinolone resistance in Neisseria gonorrhoeae. We aimed to (i) establish the ciprofloxacin MSC for N. gonorrhoeae and (ii) assess if, at the ecological level, the prevalence of gonococcal ciprofloxacin resistance is associated with the concentration of quinolones used in food animal production, which is an important determinant of long-term low-dose exposure to ciprofloxacin in humans. Methods: (i) To assess if subinhibitory ciprofloxacin concentrations could select for de novo generated resistant mutants, a susceptible WHO-P N. gonorrhoeae isolate was serially passaged at 1, 1:10, 1:100 and 1:1000 of the ciprofloxacin MIC of WHO-P (0.004 mg/L) on GC agar plates. (ii) Spearman’s correlation was used to assess the association between the prevalence of ciprofloxacin resistance in N. gonorrhoeae and quinolone use for animals and quinolone consumption by humans. Results: Ciprofloxacin concentrations as low as 0.004 µg/L (1/1000 of the MIC of WHO-P) were able to select for ciprofloxacin resistance. The prevalence of ciprofloxacin resistance in N. gonorrhoeae was positively associated with quinolone use for food animals (ρ = 0.47; p = 0.004; N = 34). Conclusion: Further individual level research is required to assess if low doses of ciprofloxacin from ingested foodstuffs are able to select for ciprofloxacin resistance in bacteria colonizing humans and other species.

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Section: Discussionmentioning

confidence: 76%

“…Certain countries in East Asia are amongst those most heavily affected. The prevalence of ciprofloxacin resistance in China, for example, increased from 10% to 95% between 1996 and 2003 [ 1 ]. In comparison, the country-level median prevalence of ciprofloxacin resistance in 2009 was 24% in the Americas and 6% in Africa [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin Concentrations 1/1000th the MIC Can Select for Antimicrobial Resistance in N. gonorrhoeae—Important Implications for Maximum Residue Limits in Food

et al. 2022

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“…N. meningitidis is one of the most antimicrobial susceptible Neisseria species, as also observed in our current study 43 . A number of genetic differences between N. meningitidis and other Neisseria have been shown to underpin the reduced capacity of N. meningitidis to acquire resistance to various antimicrobials 44 , 45 .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility of commensal Neisseria in a general population and men who have sex with men in Belgium

Laumen

Dijck

Abdellati

et al. 2022

Sci Rep

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Non-pathogenic Neisseria are a reservoir of antimicrobial resistance genes for pathogenic Neisseria meningitidis and Neisseria gonorrhoeae. Men who have sex with men (MSM) are at risk of co-colonization with resistant non-pathogenic and pathogenic Neisseria. We assessed if the antimicrobial susceptibility of non-pathogenic Neisseria among MSM differs from a general population and if antimicrobial exposure impacts susceptibility. We recruited 96 participants at our center in Belgium: 32 employees, 32 MSM who did not use antibiotics in the previous 6 months, and 32 MSM who did. Oropharyngeal Neisseria were cultured and identified with MALDI-TOF–MS. Minimum inhibitory concentrations for azithromycin, ceftriaxone and ciprofloxacin were determined using E-tests® and compared between groups with non-parametric tests. Non-pathogenic Neisseria from employees as well as MSM were remarkably resistant. Those from MSM were significantly less susceptible than employees to azithromycin and ciprofloxacin (p < 0.0001, p < 0.001), but not ceftriaxone (p = 0.3). Susceptibility did not differ significantly according to recent antimicrobial exposure in MSM. Surveilling antimicrobial susceptibility of non-pathogenic Neisseria may be a sensitive way to assess impact of antimicrobial exposure in a population. The high levels of antimicrobial resistance in this survey indicate that novel resistance determinants may be readily available for future transfer from non-pathogenic to pathogenic Neisseria.

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“…Gonococcal meningitis is characterized as an epidemic wave and, in a few cases, as a sporadic infection, both of which cause major morbidity and mortality in children and young people globally [6,7]. With the development of sulfonamide-resistant meningococci and reduced susceptibility to third-generation cephalosporins, drug prophylaxis is of little value to people with close contact [8,9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antibacterial activity of ozonated oil and ozonated water against Neisseria gonorrhoeae and Neisseria meningitidis by broth microdilution method

Yekanipour,

Afkhami,

Amini

et al. 2024

Cell. Mol. Biomed. Rep.

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The necessity of using ozonated oil and water for treating infections such as gonorrhea and meningitis which their treatment by common antibiotics is sometimes difficult and it is becoming more apparent every day. In this study, the antibacterial effect of ozonated oil and water against Neisseria gonorrhoeae (N. gonorrhoeae) and N. meningitidis were investigated using Broth microdilution methods at zero, 24 and 48 hours after incubation at 37°C. The results were determined by culturing bacteria on their specific culture medium and using an ELISA reader to determine minimum inhibitory and bactericidal concentrations (MIC and MBC, respectively). The results showed that ozonated oil with PI=500 had an expressive effect on N. meningitidis. The concentration of 0.09PI was determined as MIC and the concentration of 0.19PI was determined as MBC. The ozonated oil with PI=1000 had an expressive effect on N. gonorrhoeae. The concentration of 3.12 PI was determined as MIC and the concentration of 6.25 PI was determined as MBC. Ozonated water containing 2.5 mg/L of ozone had no significant antimicrobial effect on the studied bacterial species. The results of this study showed that ozonation of oil may improve its chemical properties. In addition, by increasing the incubation time to 24 hours, ozonated oil showed a favorable antibacterial effect against N. gonorrhoeae and N. meningitidis.

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Antibiotic Resistance in Neisseria

Cited by 17 publications

References 203 publications

Ciprofloxacin Concentrations 1/1000th the MIC Can Select for Antimicrobial Resistance in N. gonorrhoeae—Important Implications for Maximum Residue Limits in Food

Ciprofloxacin Concentrations 1/1000th the MIC Can Select for Antimicrobial Resistance in N. gonorrhoeae—Important Implications for Maximum Residue Limits in Food

Antimicrobial susceptibility of commensal Neisseria in a general population and men who have sex with men in Belgium

Evaluation of antibacterial activity of ozonated oil and ozonated water against Neisseria gonorrhoeae and Neisseria meningitidis by broth microdilution method

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