Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment

Shaskolskiy, Boris; Kandinov, Ilya; Dementieva, Ekaterina; Gryadunov, Dmitry

doi:10.3390/microorganisms10091699

Cited by 9 publications

(6 citation statements)

References 49 publications

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“…140 Cephalosporins: Third-generation cephalosporins like ceftriaxone are the first-line treatment for gonorrhea, particularly in cases of antimicrobial resistance. 141 They are also used to treat PID in combination with other antibiotics. The updated 2020 European guidelines advise a combination of two antimicrobial therapies, which involve intramuscular injection of 1 g ceftriaxone along with a single oral dose of 2 g azithromycin, or solely 1 g ceftriaxone by intramuscular injection if laboratory testing has indicated no resistance to ceftriaxone.…”

Section: Antibiotics In the Treatment Of Reproductive Tract Infectionsmentioning

confidence: 99%

Fertility treatment-induced oxidative stress and reproductive disorders

Liew,

Dutta,

Sengupta

2024

JIST

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Rising global infertility rates have amplified the dependence on assisted reproductive technologies (ARTs) for conception. This necessitates a thorough examination of fertility drug effects on reproductive health. This review explores the impact of fertility drugs, such as antioxidants, antibiotics, and antiinflammatory agents, on oxidative stress (OS), reproductive irregularities, and treatment outcomes. While antioxidants can potentially improve reproductive outcomes by modulating OS, excessive consumption can lead to the 'antioxidant paradox' -a delicate balance between external antioxidant intake, OS reduction, and its effects on fertility. Moreover, some antibiotics and anti-inflammatory drugs can intensify OS, possibly exacerbating reproductive issues. The article emphasizes the complex relationship between fertility drugs and ovarian stimulation, highlighting the need for personalized treatments and careful weighing of the advantages and drawbacks of fertility interventions. This review emphasizes the intricate relationship among fertility drugs, ovarian stimulation, and semen quality, advocating for personalized treatment plans and a thorough assessment of the benefits and drawbacks of fertility interventions. The comprehensive insights obtained from this extensive review aims to aid clinical protocols and support informed decisions in reproductive medicine.

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Section: Antibiotics In the Treatment Of Reproductive Tract Infectionsmentioning

confidence: 99%

Fertility treatment-induced oxidative stress and reproductive disorders

Liew,

Dutta,

Sengupta

2024

JIST

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“…The surveillance includes systematic monitoring of treatment failures and the use of molecular AMR prediction methods. The WHO recommends that gonorrhoea management guidelines should be revised based on recent and quality-assured gonococcal AMR surveillance data and that first-line empirical gonorrhoea treatment should be discontinued when the level of treatment failures and/or in vitro AMR reach 5% [32]. However, the evidence for the ≥ 5% AMR threshold is limited, and proportions of ≥ 1% and > 3% resistance in high-frequency transmitting populations has also been suggested [2].…”

Section: Who Surveillancementioning

confidence: 99%

Current Susceptibility Surveillance and Distribution of Antimicrobial Resistance in N. gonorrheae within WHO Regions

et al. 2022

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Neisseria gonorrhoeae (N. gonorrhoeae) is the etiological agent of the second most common sexually transmitted disease in the world, gonorrhoea. Currently recommended and last available first-line therapy is extended-spectrum cephalosporins most often combined with azitromycin. However, misuse of antibiotics and the abilities of N. gonorrhoeae to acquire new genetic and plasmid-borne resistance determinants has gradually led to the situation where this bacterium has become resistant to all major classes of antibiotics. Together with a generally slow update of treatment guidelines globally, as well as with the high capacity of gonococci to develop and retain AMR, this may lead to the global worsening of gonococcal AMR. Since effective vaccines are unavailable, the management of gonorrhoea relies mostly on prevention and accurate diagnosis, together with antimicrobial treatment. The study overviews the latest results of mostly WHO-initiated studies, primarily focusing on the data regarding the molecular basis of the resistance to the current and novel most promising antibacterial agents, which could serve to establish or reinforce the continual, quality-assured and comparable AMR surveillance, including systematic monitoring and treatment with the use of molecular AMR prediction methods.

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“…N. gonorrhoeae has developed resistance to antibiotics previously recommended for firstline empirical treatment of gonorrhoea [4] . Resistance has been reported to antibiotics including ciprofloxacin, azithromycin, cefixime, and ceftriaxone [4][5][6][7][8] . Further, resistance to ceftriaxone, the last option for monotherapy, is evolving [9] .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of Cassia abbreviata oliv roots against Neisseria gonorrhoeae: A potential traditional medicine for the treatment of sexually transmitted infections

Mudenda,

Chalwe,

Kabuka

et al. 2024

J. Med. Plants Stud.

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Traditional medicines are useful in the management of various diseases, especially in low-and middleincome countries. This study analysed the antibacterial activity of Cassia abbreviata Oliv roots against Neisseria gonorrhoeae. This was a laboratory-based study in which the extracts of Cassia abbreviata Oliv roots were tested against Neisseria gonorrhoeae. Additionally, the extracts of Cassia abbreviata Oliv roots were combined with tetracycline to determine their synergistic effect. Data were analysed using IBM SPSS version 22.0. All extracts were active against Neisseria gonorrhoeae, with a minimum inhibitory concentration of 125 µg/ml for the ethanol and 62.5 µg/ml for the aqueous extract. Despite both extracts having antibacterial activity against Neisseria gonorrhoeae, their effect were lower than that of tetracycline. There was an increase in activity when tetracycline was combined with aqueous extract. This study demonstrated that traditional medicines should be studied further for use in drug discovery, especially with increasing resistance to conventional antibiotics.

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Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment

Abstract: Gonococcal infection caused by the Gram-negative bacteria Neisseria gonorrhoeae is one of the most common sexually transmitted infections (STIs) worldwide [...]

Cited by 9 publications

References 49 publications

Fertility treatment-induced oxidative stress and reproductive disorders

Fertility treatment-induced oxidative stress and reproductive disorders

Current Susceptibility Surveillance and Distribution of Antimicrobial Resistance in N. gonorrheae within WHO Regions

Antibacterial activity of Cassia abbreviata oliv roots against Neisseria gonorrhoeae: A potential traditional medicine for the treatment of sexually transmitted infections

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