Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA)

Zhanel, George G.; Hisanaga, Tamiko; Laing, Nancy M.; DeCorby, Mel; Nichol, Kim; Weshnoweski, B.; Johnson, J.; Noreddin, Ayman M.; Low, Donald E.; Karlowsky, James A.

doi:10.1016/j.ijantimicag.2006.02.009

Cited by 229 publications

(177 citation statements)

References 25 publications

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“…According to this subject the functional mechanism of flouroqueinolones is better than FM, so the consumption of these antibiotics for UTI therapy is recommended. Resistance to this antibiotic is also increasing (6,7,11,19). In studies in Tehran and Hamedan respectively 95% and 93.4% of bacterial isolates were sensitive to CP but in our study only 57% of E. coli isolates were sensitive to this antibiotic.…”

Section: Discussioncontrasting

confidence: 61%

“…The impudence of age, gender and geographic location has previously been shown the amount of antibiotic resistance of urinary isolates (6). According to Table 3 the highest antibiotic resistance of E. coli isolates was related to NA (63%) and STX (58%).…”

Section: Discussionmentioning

confidence: 84%

“…It is important that clinicians are aware of the regional antibiotic resistance rates before initiating experiential antimicrobial therapy for UTI treatment, as it is well-described that urinary infection with a resistant pathogen is more likely to lead to bacteriological/clinical failures (6).…”

Section: Discussionmentioning

confidence: 99%

“…Despite extensive use of FM for many years, this antibiotic still possesses an excellent activity against urinary isolates of E. coli (6,7,11,16,17,19); however, compared with fluoroquinolones, the FM is associated with lower treated rates and more side effects in the treatment of acute cystitis (11,18); also, this antibiotic was poorly tolerated by children and old patients and cannot be used for pyelonephritis (5). In our study, after FM, the E. coli isolates were showing the least resistance to CTX.…”

Section: Discussionmentioning

confidence: 99%

“…There are an estimated 150 million UTIs per year, worldwide (3,4). The clinical significance of the infections is due to its high mortality rate, malignant and chronic hypertensions and the chronic renal failures followed by chronic pyelonephritis (5,6). The severity of UTI depends on the bacteria virulence and susceptibility of the host (7).…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic Resistance of Isolated Gram Negative Bacteria From Urinary Tract Infections (UTIs) in Isfahan

Mirzarazi

Rezatofighi

Pourmahdi

et al. 2013

Jundishapur J Microbiol

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Background: Urinary tract infection (UTI) is a common bacterial disease which may cause chronic renal failure and hypertension. Many reports suggest that the rate of antibiotic resistance to infectious organisms is increasing.Objectives: This study aimed to detect and also compare the frequency and drug resistance pattern of Gram negative bacteria isolated from patients with community-acquired UTIs in Isfahan.Patients and Methods: In this cross-sectional descriptive study, 702 samples from 476 females and 226 males referred to medical centers in Isfahan city from June to September 2011 were collected, we investigated the urine cultures and antibiotic sensitivity of the isolated organisms were measured.Results: Urinary infectious was detected in 203 persons. The most prevalence isolated bacteria were Escherichia coli 138 (68%), followed by Klebsiella spp. (13%). Antibiotic resistance pattern of Gram negative bacteria isolated was investigated. Among E. coli isolates the most antibiotic sensitivity and resistance were related to Nitrofurantoin, Cotrimoxazol and Nalidixic acid, Trimetsulpha respectively. Klebsiella spp. isolates were the most antibiotic sensitive to Cotrimoxazol and Cipropheloxacin and the most antibiotic resistant to Trimetsulpha, Cipropheloxacin and Nalidixic respectively.Conclusions: With regards to the continuous changing in causative microorganisms isolated from patients with UTI and antibiotic sensitivity patterns, it is recommended that bacterial sensitivity patterns in populations are determined in any region annually

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibiotic Resistance of Isolated Gram Negative Bacteria From Urinary Tract Infections (UTIs) in Isfahan

Mirzarazi

Rezatofighi

Pourmahdi

et al. 2013

Jundishapur J Microbiol

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Cranberry Polyphenols in the Promotion of Urinary Tract, Cardiovascular and Emerging Health Areas

Kaspar¹,

Khoo²

2013

Bioactives in Fruit

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The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X‐ray Crystallography

et al. 2015

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Urinary tract infections caused by uropathogenic E. coli are among the most prevalent infectious diseases. The mannose-specific lectin FimH mediates the adhesion of the bacteria to the urothelium, thus enabling host cell invasion and recurrent infections. An attractive alternative to antibiotic treatment is the development of FimH antagonists that mimic the physiological ligand. A large variety of candidate drugs have been developed and characterized by means of in vitro studies and animal models. Here we present the X-ray co-crystal structures of FimH with members of four antagonist classes. In three of these cases no structural data had previously been available. We used NMR spectroscopy to characterize FimH-antagonist interactions further by chemical shift perturbation. The analysis allowed a clear determination of the conformation of the tyrosine gate motif that is crucial for the interaction with aglycone moieties and was not obvious from X-ray structural data alone. Finally, ITC experiments provided insight into the thermodynamics of antagonist binding. In conjunction with the structural information from X-ray and NMR experiments the results provide a mechanism for the often-observed enthalpy-entropy compensation of FimH antagonists that plays a role in fine-tuning of the interaction.

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Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA)

Cited by 229 publications

References 25 publications

Antibiotic Resistance of Isolated Gram Negative Bacteria From Urinary Tract Infections (UTIs) in Isfahan

Antibiotic Resistance of Isolated Gram Negative Bacteria From Urinary Tract Infections (UTIs) in Isfahan

Cranberry Polyphenols in the Promotion of Urinary Tract, Cardiovascular and Emerging Health Areas

The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X‐ray Crystallography

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