Antibiotic resistance: Global health crisis and metagenomics

Abstract

Highlights Antimicrobial resistance is global risk to both humans & environment health. Aquatic system serves as hotspot for dissemination of AMR. Metagenomics can be used for monitoring abundance of ARGs in environment. Application of metagenomics has potential to yield novel secondary metabolites having antimicrobial potential.

A New Ceramide (Rumexamide) and Other Chemical Constituents from <i>Rumex abyssinicus</i> Jacq (Polygonaceae): Isolation, Characterization, Antibacterial Activities and Chemophenetic Significance

“…In conclusion, the chemical study of the whole plant of R. abyssinicus led to the isolation of one previously undescribed ceramide (1) and sixteen known (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) compounds which enriched the chemical diversities of the plant, genus Rumex and Polygonaceae family. Compounds 10-12 may demonstrate here the relationship between F. aubertii and other species belonging to other genera herbs of Polygonaceae.…”

“…However, their overexploitation has caused the appearance and increase in the rate of resistance of microorganisms to said antibiotics [1]. It is well established that this resistance is nowadays responsible for nearly 7 million deaths per year and it is estimated that it will reach to 10 million deaths per year by 2050 [2]. Thus, in order to overcome this state of affairs, efforts are being made to find new antimicrobial agents such as medicinal plants [3].…”

Photoinactivation of Catalase Sensitizes Wide-Ranging Bacteria to ROS-Producing Agents and Immune Cells

“…Since the discovery of penicillin in 1928 by Alexander Fleming 64 , there was a golden age (from 1940s to 1960s) for the discovery of antibiotics, most of which remain in clinical use today 65 . Yet, imprudent usage of antibiotics speeded up the natural selection of drug-resistant bacteria 66 . In the past decades, the ever-rising emergence of multidrug-resistant bacteria has been an alarming threat worldwide.…”

Microbiome Studies from Saudi Arabia over the Last 10 Years: Achievements, Gaps, and Future Directions

“…Metagenome can be a valuable tool to identify and monitor antimicrobial resistance genes (ARGs). Metagenome-based analysis reveals that water treatment plants (urban wastewater and sewage) area hotspot for ARGs [ 44 , 45 ]. Metagenome analysis of mangrove microbiome and glacial lake sediments also show the presence of ARGs [ 38 , 46 ].…”