Antibiotic resistance genes in bacteria: Occurrence, spread, and control

Jian, Zonghui; Zeng, Li; Xu, Taojie; Sun, Shuai; Yan, Shixiong; Yang, Lan; Huang, Ying; Jia, Junjing; Dou, Tengfei

doi:10.1002/jobm.202100201

Cited by 116 publications

(84 citation statements)

References 155 publications

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“…Transduction is a process mediated by bacteriophages. Bacteriophages infect bacteria, and after bacteria lysis, they can incorporate DNA fragments that will be transferred to another bacteria genome [27,28]. Bacterial membrane vesicles carry lipids, proteins, and DNA that can be released to the external environment under stressful conditions, fuse, and transform other bacteria [29].…”

Section: Horizontal Gene Transfermentioning

confidence: 99%

Antibiotic Resistance in the Drinking Water: Old and New Strategies to Remove Antibiotics, Resistant Bacteria, and Resistance Genes

et al. 2022

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Bacterial resistance is a naturally occurring process. However, bacterial antibiotic resistance has emerged as a major public health problem in recent years. The accumulation of antibiotics in the environment, including in wastewaters and drinking water, has contributed to the development of antibiotic resistant bacteria and the dissemination of antibiotic resistance genes (ARGs). Such can be justified by the growing consumption of antibiotics and their inadequate elimination. The conventional water treatments are ineffective in promoting the complete elimination of antibiotics and bacteria, mainly in removing ARGs. Therefore, ARGs can be horizontally transferred to other microorganisms within the aquatic environment, thus promoting the dissemination of antibiotic resistance. In this review, we discuss the efficiency of conventional water treatment processes in removing agents that can spread/stimulate the development of antibiotic resistance and the promising strategies for water remediation, mainly those based on nanotechnology and microalgae. Despite the potential of some of these approaches, the elimination of ARGs remains a challenge that requires further research. Moreover, the development of new processes must avoid the release of new contaminants for the environment, such as the chemicals resulting from nanomaterials synthesis, and consider the utilization of green and eco-friendly alternatives such as biogenic nanomaterials and microalgae-based technologies.

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Section: Horizontal Gene Transfermentioning

confidence: 99%

Antibiotic Resistance in the Drinking Water: Old and New Strategies to Remove Antibiotics, Resistant Bacteria, and Resistance Genes

et al. 2022

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“…In light of the above-described uncertainty regarding the specific role(s) of Hfq in ColE1-type plasmid replication and considering the recently identified effects of CTR of this protein on plasmid biology [18], it is clear that detailed studies on interactions of different domains of Hfq with NA involved in ColE1 DNA replication are crucial. Such studies are also important because plasmid-borne antibiotic resistance is a serious medical problem; thus, understanding details of molecular mechanisms of plasmid DNA replication regulation may indicate ways to limit this very adverse phenomenon [3,4]. On the other hand, methods for precise studies on interactions between small proteins and NA are restricted.…”

Section: Hfq-ctr Stabilizes the C-stretch Region Of Cole1 Plasmid Dnamentioning

confidence: 99%

“…Plasmids are extrachromosomal genetic elements that are carriers of many antibiotic resistance genes, thus being responsible for both the efficient survival of bacteria in the presence of antibiotics and many events of horizontal gene transfer, causing effective spreading of antibiotic resistance [4]. Among all kinds of plasmids occurring in Gram-negative bacteria, ColE1-like (or ColE1-type) replicons frequently occur under natural conditions, and they can contribute significantly to the transmission of resistance among pathogenic strains.…”

Section: Introductionmentioning

confidence: 99%

Synchrotron Radiation Circular Dichroism, a New Tool to Probe Interactions between Nucleic Acids Involved in the Control of ColE1-Type Plasmid Replication

et al. 2022

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Hfq is a bacterial master regulator which promotes the pairing of nucleic acids. Due to the high molecular weight of the complexes formed between nucleic acids and the amyloid form of the protein, it is difficult to analyze solely by a gel shift assay the complexes formed, as they all migrate at the same position in the gel. In addition, precise kinetics measurements are not possible using a gel shift assay. Here, we used a synchrotron-based biophysical approach, synchrotron radiation circular dichroism (SRCD), to probe the interaction of the Escherichia coli Hfq C-terminal amyloid region with nucleic acids involved in the control of ColE1-like plasmid replication. We observed that this C-terminal region of Hfq has an unexpected and significant effect on the annealing of nucleic acids involved in this process and, more importantly, on their alignment. Functional consequences of this newly discovered property of the Hfq amyloid region are discussed in terms of the biological significance of Hfq in the ColE1-type plasmid replication process and antibiotic resistance.

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“…Antimicrobial resistance is one of the most serious threats to global health care [ 1 , 2 ]. In the last two decades, an increased number of infections caused by multidrug-resistant Gram-negative bacteria (MDR-GNB) have been reported [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Rectal and Tracheal Carriage of Carbapenemase Genes and Class 1 and 2 Integrons in Patients in Neurosurgery Intensive Care Unit

et al. 2022

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The spread of multidrug-resistant Gram-negative bacteria, which is associated with the distribution of beta-lactamase genes and class 1 and 2 integrons, is a global problem. In this study, in the Moscow neurosurgery intensive care unit (neuro-ICU), the high prevalence of the above-stated genes was found to be associated with intestinal and tracheal carriage. Seven-point prevalence surveys, which included 60 patients in the neuro-ICU, were conducted weekly in the period from Oct. to Nov. 2019. A total of 293 clinical samples were analyzed, including 146 rectal and 147 tracheal swabs; 344 Gram-negative bacteria isolates were collected. Beta-lactamase genes (n = 837) were detected in the isolates, including beta-lactamase blaTEM (n = 162), blaSHV (n = 145), cephalosporinase blaCTX–M (n = 228), carbapenemase blaNDM (n = 44), blaKPC (n = 25), blaOXA–48 (n = 126), blaOXA–51–like (n = 54), blaOXA–40-like (n = 43), blaOXA–23-like (n = 8), and blaVIM (n = 2), as well as class 1 (n = 189) and class 2 (n = 12) integrons. One extensively drug-resistant Klebsiella pneumoniae strain (sequence type ST39 and capsular type K23), simultaneously carried beta-lactamase genes, blaSHV–40 and blaTEM–1B, three carbapenemase genes, blaNDM, blaKPC, and blaOXA–48, the cephalosporinase gene blaCTX–M, and two class 1 integrons. Before this study, such heavily armed strains have not been reported, suggesting the ongoing evolution of antibiotic resistance.

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Antibiotic resistance genes in bacteria: Occurrence, spread, and control

Cited by 116 publications

References 155 publications

Antibiotic Resistance in the Drinking Water: Old and New Strategies to Remove Antibiotics, Resistant Bacteria, and Resistance Genes

Antibiotic Resistance in the Drinking Water: Old and New Strategies to Remove Antibiotics, Resistant Bacteria, and Resistance Genes

Synchrotron Radiation Circular Dichroism, a New Tool to Probe Interactions between Nucleic Acids Involved in the Control of ColE1-Type Plasmid Replication

Rectal and Tracheal Carriage of Carbapenemase Genes and Class 1 and 2 Integrons in Patients in Neurosurgery Intensive Care Unit

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