Antibiotic resistance gene profiling in response to antibiotic usage and environmental factors in the surface water and groundwater of Honghu Lake, China

Tong, Lei; Qin, Liting; Guan, Chunlin; Wilson, Mesmire; Li, Xianju; Cheng, Dandan; Ma, Jie; Liu, Hui; Gong, Fujun

doi:10.1007/s11356-020-09487-5

Cited by 66 publications

(22 citation statements)

References 54 publications

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“…The discrepancy was due to a shortfall in the stormwater compartment. More specifically, the groundwater, 16–35 livestock manure, 36–55 drinking water, 56–75 and wastewater 25,57,76–93 compartments each included the target number of 20 documents, while the stormwater ( n = 12) 26,94–104 compartment did not have enough documents meeting our criteria (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…The discrepancy was due to a shortfall in the stormwater compartment. More specifically, the groundwater, [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] livestock manure, [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] drinking water, [56][57][58][59][60][61][62][63][64][65][66][67]…”

Section: Characteristics Of Reviewed Documentsmentioning

confidence: 99%

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Targeting current and future threats: recent methodological trends in environmental antimicrobial resistance research and their relationships to risk assessment

Burch

Newton

Kimbell

et al. 2022

Environ. Sci.: Water Res. Technol.

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Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Reviewed Documentsmentioning

confidence: 99%

Targeting current and future threats: recent methodological trends in environmental antimicrobial resistance research and their relationships to risk assessment

Burch

Newton

Kimbell

et al. 2022

Environ. Sci.: Water Res. Technol.

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“…Meanwhile, we also found that DO, pH and CON were three most important factors affecting ARGs. It has also been reported that DO and pH had signi cant effect on the abundance of ARGs (Tong et al, 2020). These environmental factors also are drivers in shaping microbial community (Yang et al, 2019;Zhou et al, 2021).…”

Section: Carcass Decay Changes Environmental Properties and Thus Affects The Resistomesmentioning

confidence: 92%

Corpse Degradation of Farmed Fish Increases the Abundance of Antibiotic Resistance Genes but Exhibits the Temporal Stability

et al. 2021

Preprint

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Serious concerns have been raised regarding resistomes causing by corpse decomposition in the aquatic environment, which pose threats to the water environment and human health. However, antibiotic resistance genes (ARGs) in large-volume tap water and their temporal stability during corpse decay are poorly explored. Here, high-throughput quantitative polymerase chain reaction (HT-qPCR) and amplicon sequencing were applied to profile ARGs and bacterial communities in experimental and control groups containing 50 L of tap water at 7th, 15th and 100th day during corpse decomposition. We found that most of the ARGs in experimental groups had higher abundance compared with the control groups independent of time. And the absolute abundance of some ARGs in the carcass groups was even enriched by 259 to 413,640-folds. The tetracycline and beta-lactamase resistance genes of the experimental groups were obviously enriched compared with control groups, and the ARG profiles were convergent during different decay stages, which indicated the long-term persistence of ARGs. Treatment, dissolved oxygen (DO) and pH were three important factors determining ARG profiles during corpse decomposition. Twelve opportunistic pathogens, especially Burkholderia, Legionella and Halomonas, remarkably increased as decomposition proceeded. Network analysis showed that opportunistic pathogens were significantly associated with ARGs. Our results emphasize that corpse decay increases the abundance and diversity of ARGs in large-volume drinking water independent of time while exhibits temporal persistence of ARGs, thereby uncovering the harmful effects of animal cadavers. It also provides valuable suggestions for the risk assessment and management of source water caused by corpse decay.

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“…The sediment extract samples were analyzed through liquid chromatography with tandem mass spectrometry (LC-MS/MS), which were determined according to the procedures described in previous study (Tong et al, 2020). The samples were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) using an Accela Max 600 high performance liquid chromatography system with an online degasser, quaternary solvent transport system, automatic sampler, TSQ Quantum Access Max (ESI) source and electrospray ionization source.…”

Section: Quanti Cation Of Antibioticsmentioning

confidence: 99%

Occurrence and influencing factors of antibiotics and antibiotic resistance genes in sediments of the largest multi-habitat lakes in Northern China

Wang

Zhang

Liao

et al. 2022

Environ Geochem Health

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Baiyangdian Lake is a typical and largest multi-habitat lake in the North plain of China. To understand the generation and transmission of antibiotics resistance genes (ARGs) in multi-habitat lakes, the contents of nutrients (TC, TOC, TN, TP and TS), heavy metals (Zn, Cr, Ni, Cu, Pb, As, Cd and Hg), 22 antibiotics, 16S-rRNA(16S), Class I integron (intI1) and 20 ARGs were determined. Samples were taken from the Fuhe river, river estuaries, reed marshes, living area, sh poods and open water of Baiyangdian Lake. The results showed that quinolones (QNs) were the main pollutants, and the content range was ND-104.94 ng/g. Thereinto, aac (6') -IB, blaTEM-1, ermF, qnrA, qnrD, tetG, sul1, sul2 and tetM were detected in 100%. The absolute abundance of sul1 was the highest (5.25×10 5 copies/g-6.21×10 7 copies/g), which was the dominant ARGs. In these different habitats, the abundance of antibiotics and ARGs in river estuary was the highest, and that in reed marshes was the lowest. There was a signi cant positive correlation between the abundance of heavy metals (Cu, Pb, Zn, Ni, Cd, Hg) and the absolute abundance of 11 ARGs (P<0.01). Redundancy analysis showed that Cu, Zn, intI1, TP and macrolides (MLs) were the important factors affecting the distribution of ARGs. Our ndings provides a more likely driving and in uencing factor for the transmission of ARGs in lakes with complex and diverse habitats.

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Antibiotic resistance gene profiling in response to antibiotic usage and environmental factors in the surface water and groundwater of Honghu Lake, China

Cited by 66 publications

References 54 publications

Targeting current and future threats: recent methodological trends in environmental antimicrobial resistance research and their relationships to risk assessment

Targeting current and future threats: recent methodological trends in environmental antimicrobial resistance research and their relationships to risk assessment

Corpse Degradation of Farmed Fish Increases the Abundance of Antibiotic Resistance Genes but Exhibits the Temporal Stability

Occurrence and influencing factors of antibiotics and antibiotic resistance genes in sediments of the largest multi-habitat lakes in Northern China

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