Antibiotic resistance: bioinformatics-based understanding as a functional strategy for drug design

Ndagi, Umar; Falaki, Abubakar A.; Abdullahi, Maryam; Lawal, Monsurat M.; Soliman, Mahmoud E. S.

doi:10.1039/d0ra01484b

Cited by 53 publications

(39 citation statements)

References 121 publications

(256 reference statements)

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“…Some countries may report data from national surveillance systems with broad population coverage, and others may report data from a subset of local laboratories, clinics, and healthcare settings focusing on one area and limiting the representativeness of data on the national level [ 55 ]. As the validity of surveillance systems relies on the comparability of participating laboratories [ 180 ], each may have different trends of AMR surveillance and different level of capacity for identifying the microorganisms and may show differences in the applied methodology and quality assurance limiting benchmarking [ 55 , 181 , 182 ]. Other inconsistencies across participating laboratories include differences in sampling, the use of different clinical case definitions, and the heterogeneous healthcare utilization [ 181 ].…”

Section: Discussionmentioning

confidence: 99%

“…As the validity of surveillance systems relies on the comparability of participating laboratories [ 180 ], each may have different trends of AMR surveillance and different level of capacity for identifying the microorganisms and may show differences in the applied methodology and quality assurance limiting benchmarking [ 55 , 181 , 182 ]. Other inconsistencies across participating laboratories include differences in sampling, the use of different clinical case definitions, and the heterogeneous healthcare utilization [ 181 ]. Standardization of data management is the most challenging task if health information technology and adequate training are lacking.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture

Iskandar

Molinier

Hallit

et al. 2021

Antimicrob Resist Infect Control

201

144

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Data on comprehensive population-based surveillance of antimicrobial resistance is lacking. In low- and middle-income countries, the challenges are high due to weak laboratory capacity, poor health systems governance, lack of health information systems, and limited resources. Developing countries struggle with political and social dilemma, and bear a high health and economic burden of communicable diseases. Available data are fragmented and lack representativeness which limits their use to advice health policy makers and orientate the efficient allocation of funding and financial resources on programs to mitigate resistance. Low-quality data means soaring rates of antimicrobial resistance and the inability to track and map the spread of resistance, detect early outbreaks, and set national health policy to tackle resistance. Here, we review the barriers and limitations of conducting effective antimicrobial resistance surveillance, and we highlight multiple incremental approaches that may offer opportunities to strengthen population-based surveillance if tailored to the context of each country.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture

Iskandar

Molinier

Hallit

et al. 2021

Antimicrob Resist Infect Control

201

144

View full text Add to dashboard Cite

show abstract

“…Results showed the most isolated bacteria which has multi‫ـ‬antibiotics, resistance is P. aeruginosa and followed by S. aureus, E.coli and Proteus vulgaris. this either could belong to their ability to acquire the genes that responsible for drug resistance from other bacteria in the environment though plasmid or other vector by conjugation or any methods of gene transfer, or belong to ability of Gram negative bacteria especially P. aeruginosa to form biofilm that protect bacteria from the effect of host immunity and antibiotics [24][25][26] . P. aeruginosa is one of the most important pathogens causing different infections such as bacteremia and burn infection [27] .…”

Section: Discussionmentioning

confidence: 99%

Detection of the Some Dominant Aerobic Microorganisms in Burn Injury and Testing their Susceptibility for Different Antibiotics in Najaf

Alwaeli¹

2020

Indian Journal of Forensic Medicine & Toxicology

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Burn injury and wound is a pig problem that assists the pathogens to grow and cause infection. 149 burn injury swabs were taken from different site of the patients' body ages (11-53 years old). All samples were tested to isolate the sigificant microorganisms that found in burn injury. Antibiotics test was performed by using disc diffusion way that stated by Kirby-Baucer. Results appeared that the most frequent pathogen in burn injury was Pseudomonas aeruginosa 33(22.14%) and followed by E.coli 31(20.8%), Staphylococcus aureus 28(18.79%), Proteus vulgaris 26(17.48%), Coagulase-negative Staphylococci 12(8.05%), Proteus mirabilis 10(6.71%), Klebsiella pneumonia 5(3.35%) and Candida spp. 4(2.68%) respectively. Antibiotic test showed that Staphylococcus aureus was a high resistance against Gentamycin and ciprofloxacin, but it was sensitive to Vancomycin and Imipenem. Coagulase negative Staphylococci showed a resistance to Gentamicin, Ciprofloxacin and Ceftazidime, but it was sensitive to Amikacin, Oxacillin, Cefotaxim, Vancomycin, Imipenem and Cefepime. P. aeruginosa showed resistance against Cefotaxime, Aztreonam, Gentamicin and Ceftazidime. Whlist it showed a high sensitivity against Imipenem, Cefepime and Tobramycin. E.coli showed a high resistance against Ceftriaxone, Ciprofloxacin and Cephalothin. whilst it showed a high sensitivity against Ticarcillin/clavulanic acid, Imipenem, Cefepime and Tobramycin. Proteus vulgaris showed a high resistance against Ceftriaxone, Ceftazidime, Amikacin, Cephalothin and Gentamicin. Whilst it showed a high sensitivity against Cefotaxime, Aztreonam, Ticarcillin/clavulanic acid and Imipenem. Proteus mirabilis showed resistance against Amikacin, Ciprofloxacin, Ceftriaxone, Gentamicin and Cephalothin. Whilst it showed a high sensitivity against Ceftazidime, Cefotaxime, Aztreonam, Ticarcillin/clavulanic acid, Imipenem, Cefepime and Tobramycin. Klebsiella pneumonia showed resistance against Ciprofloxacin, Ceftazidime, Cefotaxime and Aztreonam. whilst it showed a high sensitivity against Ceftriaxone, Amikacin, Gentamicin, Cephalothin, Ticarcillin/clavulanic acid, Imipenem, Cefepime and Tobramycin. The current study was aimed to determine the most frequent pathogens in burn injury and test their antibiotics susceptibility in hospitalize patients in Najaf city.

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“…Annually, around a quarter of all registered deaths across the world are caused by viruses, bacteria and fungi [ 8 , 9 ]. The above-mentioned problems necessitate a rational approach to the design of a new generation of antibiotics [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties

Ermolaev

Arkhipova

Miluykov

et al. 2021

IJMS

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Structure–activity relationships are important for the design of biocides and sanitizers. During the spread of resistant strains of pathogenic microbes, insights into the correlation between structure and activity become especially significant. The most commonly used biocides are nitrogen-containing compounds; the phosphorus-containing ones have been studied to a lesser extent. In the present study, a broad range of sterically hindered quaternary phosphonium salts (QPSs) based on tri-tert-butylphosphine was tested for their activity against Gram-positive (Staphylococcus aureus, Bacillus сereus, Enterococcus faecalis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria and fungi (Candida albicans, Trichophyton mentagrophytes var. gypseum). The cation structure was confirmed to determine their biological activity. A number of QPSs not only exhibit high activity against both Gram-positive and -negative bacteria but also possess antifungal properties. Additionally, the hemolytic and cytotoxic properties of QPSs were determined using blood and a normal liver cell line, respectively. The results show that tri-tert-butyl(n-dodecyl)phosphonium and tri-tert-butyl(n-tridecyl)phosphonium bromides exhibit both low cytotoxicity against normal human cells and high antimicrobial activity against bacteria, including methicillin-resistant strains S. aureus (MRSA). The mechanism of QPS action on microbes is discussed. Due to their high selectivity for pathogens, sterically hindered QPSs could serve as effective tunable biocides.

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Antibiotic resistance: bioinformatics-based understanding as a functional strategy for drug design

Abstract: Understanding the evolution of antibiotic resistance at the molecular level as a functional tool for bioinformatic-based drug design.

Cited by 53 publications

References 121 publications

Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture

Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture

Detection of the Some Dominant Aerobic Microorganisms in Burn Injury and Testing their Susceptibility for Different Antibiotics in Najaf

Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties

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