Antibiotic Resistance Among Ocular Pathogens in the United States

Asbell, Penny A.; Sanfilippo, Christine M; Pillar, Chris M.; DeCory, Heleen H; Sahm, Daniel F.; Morris, Timothy W.

doi:10.1001/jamaophthalmol.2015.3888

Cited by 135 publications

(95 citation statements)

References 48 publications

(14 reference statements)

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“…Overall these three organisms did not show alarming resistance to the antimicrobials tested and are consistent with other antimicrobial surveillance studies that have been conducted recently [1, 7, 13, 19]. …”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Retrospective report of antimicrobial susceptibility observed in bacterial pathogens isolated from ocular samples at Mount Sinai Hospital, 2010 to 2015

Oydanich

Dingle

Hamula

et al. 2017

Antimicrob Resist Infect Control

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BackgroundAntimicrobial resistance has emerged as a major threat to global public health. Thus, the surveillance of changes in antimicrobial resistance in local and global settings is a paramount necessity. While many studies have tracked antimicrobial resistance, only a small percentage surveyed ocular isolates. The purpose of this study was to report the in vitro susceptibility of bacterial pathogens isolated from ocular samples in New York, NY from 2010 to 2015.MethodsA retrospective review of ocular isolates was conducted. All organisms were collected by 25 separate inpatient wards and outpatient clinics, and were analyzed by the clinical microbiology laboratory at Mount Sinai Hospital. Clinical Laboratory and Standards Institute (CLSI) guidelines were followed for susceptibility testing and breakpoint interpretations.ResultsA total of 549 bacterial organisms were isolated from 1664 cultures (33%) during the 6-year study period. Of these, 358 isolates (65.2%) underwent susceptibility testing. 182 (50.8%) isolates were Gram-positive. The most common Gram-positive bacterium was Staphylococcus aureus (62.1%). Methicillin-resistance decreased in S. aureus isolates (31.3% in 2010, 14.1% in 2015) but was without significant change (p = 0.25). When analyzing all S. aureus isolates recovered during the study period, there were significantly more methicillin-resistant S. aureus (MRSA) isolates resistant to fluoroquinolones (p <0.0001), erythromycin (p <0.0001), and trimethoprim/sulfamethoxazole (TMP/SMZ; p <0.05). Overall, Streptococcus pneumoniae isolates showed reduced susceptibility to erythromycin, but were otherwise susceptible to the other antimicrobials tested. Haemophilus influenzae (26.1%) and Pseudomonas aeruginosa (23.9%) were the most common Gram-negative bacteria isolated. Resistance to ampicillin and TMP/SMZ was observed in several of the H. influenzae isolates. P. aeruginosa isolates did not show high resistance overall, however, it was noted that isolates resistant to meropenem were also resistant to other antimicrobials (p < 0.01).ConclusionOverall, antimicrobial resistance was infrequent for the Gram-negative and Gram-positive bacteria analyzed. While the MRSA isolates demonstrated increased resistance to multiple antimicrobial classes, this is expected for this pathogen. Due to the continued use of broad-spectrum oral and systemic antimicrobials to treat ocular infections, findings of this study and other surveillance studies specific to ocular isolates should be used as resources in effective decision making in the treatment of ocular disease.

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Section: Discussionsupporting

confidence: 89%

“…There have been a few nationwide surveillance studies, such as Ocular TRUST and ARMOR, which have tracked resistance patterns in many common ocular pathogens [9, 13]. However, given the growing importance of this issue, there is also a need for smaller, regional studies to obtain local data.…”

Section: Introductionmentioning

confidence: 99%

Retrospective report of antimicrobial susceptibility observed in bacterial pathogens isolated from ocular samples at Mount Sinai Hospital, 2010 to 2015

Oydanich

Dingle

Hamula

et al. 2017

Antimicrob Resist Infect Control

View full text Add to dashboard Cite

show abstract

“…Eighty-one percent of the indefinable ( n = 216) P. aeruginosa isolates from the ARMOR study were from the cornea. [11] BPEI data for 2011-2015 mirrored these results.…”

Section: Resultsmentioning

confidence: 63%

Update on the epidemiology and antibiotic resistance of ocular infections

Miller

2017

Middle East Afr J Ophthalmol

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“…7,9 However, increasing degrees of antimicrobial resistance in gram-negative organisms is a concern in other parts of the world. In the EVS, 89.5% of gram-negative bacteria were sensitive to both amikacin and ceftazidime.…”

Section: Emerging Worldwide Antimicrobial Resistancementioning

confidence: 99%

“…6 In 1999, Kunimoto et al from India reported incomplete susceptibility of gram-negative isolates for ciprofloxacin (87.5%), amikacin (82.1%) and ceftazidime (60.9%). 9 Also Dave et al in 2016 reported 11 cases of endophthalmitis from India caused by ceftazidime-resistant gram-negative organisms. These cases were subsequently managed with intravitreal imipenem.…”

Section: Emerging Worldwide Antimicrobial Resistancementioning

confidence: 99%