Antibiotic Prophylaxis of Late Bacteremic Vascular Graft Infection in a Dog Model

Update on the Use of Antibiotics in Cutaneous Surgery

“…However, to our knowledge, no human studies exist that specifically evaluate the benefits of bacteremia prophylaxis in the prevention of vascular graft infection. Animal studies have been performed and demonstrate the efficacy of ceftriaxone in preventing synthetic graft infection with S. aureus after bacteremia 155. Elective cutaneous surgery in a patient who has recently undergone vascular graft placement should probably be delayed 6 to 12 months if possible to allow the formation of as much pseudointima as possible.…”

“…Animal studies have been performed and demonstrate the efficacy of ceftriaxone in preventing synthetic graft infection with S. aureus after bacteremia. 155 Elective cutaneous surgery in a patient who has recently undergone vascular graft placement should probably be delayed 6 to 12 months if possible to allow the formation of as much pseudointima as possible. A discussion with the patient's vascular surgeon would be prudent if the surgery is for cancer or other more urgent skin disease.…”