Antibiotic prophylaxis of acute postoperative endophthalmitis

Nikolaenko, Vadim P.; Belov, D.F.

doi:10.32364/2311-7729-2021-21-4-220-226

Cited by 3 publications

(1 citation statement)

References 40 publications

(45 reference statements)

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“…In terms of the etiology of the disease, bacterial and fungal endophthalmitis are distinguished [ 3 , 4 , 5 ]. Bacterial endophthalmitis, caused by Staphylococcus epidermidis, Staphylococcus aureus, Streptococcus, Enterococcus, and Gram-negative bacilli, is the most common [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Intravitreal In Situ Implant of Cefuroxime Based on Poloxamer 407 and Hyaluronic Acid

Bakhrushina,

Dubova,

Nikonenko

et al. 2023

Gels

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The main method of treatment and prevention of endophthalmitis is a combination of intravitreal and topical administration of antibiotics, such as cefuroxime moxifloxacin or vancomycin. However, this method is ineffective due to the rapid elimination of the drug. This problem can be solved with the help of intravitreal in situ injection systems, which are injected with a syringe into the vitreous body and provide prolonged action of the drug at the focus of inflammation. Under the influence of temperature, the liquid drug undergoes a phase transition and turns into a gel after injection. This ensures its prolonged action. The study aimed to develop an intravitreal in situ cefuroxime delivery system for the treatment of endophthalmitis based on a thermosensitive biodegradable composition of poloxamer 407 and hyaluronic acid. A combination of poloxamer Kolliphor® P407, Kolliphor® P188, and PrincipHYAL® hyaluronic acids of different molecular weights was used as a delivery system. The potency of cefuroxime solid dispersion with polyvinylpyrrolidone-10000, polyethylene glycol-400, and polyethylene glycol-1500 in a 1:2 ratio was studied for prolonged action compared to cefuroxime substance. The experimental formulations were studied for the parameters of gelation temperature in a long-term test (4 months), pH, and release of cefuroxime using dialysis bags. To study the distribution parameter in the vitreous body, an in vitro model (1/13) was developed, which was a hollow agar sphere filled with 1% (w/v) polyacrylate gel. For the superior formulations, a HET-CAM test (chorioallantoic membrane test) was performed to determine the absence of irritant effects. According to the study results, a formulation containing a solid dispersion of cefuroxime:PEG-400 (1:2), the matrix of which contained 18% (w/v) Kolliphor® P407 poloxamer, 3% (w/v) Kolliphor® P188 poloxamer, and 0.5% (w/v) hyaluronic acid (1400–1800), was selected. This sample had an average gelation temperature of 34.6 °C, pH 6.7 ± 0.5, and a pronounced prolonged effect. Only 7.6% was released in 3 h of the experiment, whereas about 38% of cefuroxime was released in 72 h. No irritant effect on the chorioallantoic membrane was observed for any formulations studied.

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Section: Introductionmentioning

confidence: 99%

Thermosensitive Intravitreal In Situ Implant of Cefuroxime Based on Poloxamer 407 and Hyaluronic Acid

Bakhrushina,

Dubova,

Nikonenko

et al. 2023

Gels

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Clinical features and treatment of endophthalmitis after cataract surgery

Nikolaenko¹,

Belov²

2023

Vestn. oftal'mol.

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Modern clinical, functional, and ophthalmo-ergonomic features of phacoemulsification in patients with visual-intense labor with bilateral cataract: a systematic review

Kozhukhov¹,

Ovechkin

Kumar

et al. 2023

Russian Medicine

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A systematic review was performed using databases of RSCI and PubMed, and the following keywords were used for the literature search: Cataract, Phacoemulsification, PEC, Visual-stress work, VSW, Anisometropia, and Quality of life. Articles were selected based on the criteria for prospective or retrospective studies. A total of 684 sources were analyzed, further using systematic review filters and authors knowledge of the topic. The retrospective analysis covered the period from 2016 to 2022. Data indicate that the current state of the problem of PEK in patients with VSW with bilateral cataracts during traditional sequential (on different days) surgery (especially if the interval between operations increased by more than 710 days) is accompanied by the emergence of clinical, functional (pain syndrome, anisometropia, diplopia, and impaired stereoscopic vision), and ophthalmo-ergonomic (insufficient level of visual performance) adverse manifestations after the first surgery. To eliminate them, sequential bilateral cataract surgery received increasing attention (both operations within the same day), characterized by fewer hospital visits for the patient, faster recovery of vision, and lower healthcare costs. Thus, the stated provisions in the dispensary observation of patients with VSW with bilateral cataracts must be considered.

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Antibiotic prophylaxis of acute postoperative endophthalmitis

Cited by 3 publications

References 40 publications

Thermosensitive Intravitreal In Situ Implant of Cefuroxime Based on Poloxamer 407 and Hyaluronic Acid

Thermosensitive Intravitreal In Situ Implant of Cefuroxime Based on Poloxamer 407 and Hyaluronic Acid

Clinical features and treatment of endophthalmitis after cataract surgery

Modern clinical, functional, and ophthalmo-ergonomic features of phacoemulsification in patients with visual-intense labor with bilateral cataract: a systematic review

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