Antibiotic prophylaxis in total hip replacement.

Joint prosthetic infections: A success story

“…During the past few decades, several studies have shown that short-term prophylaxis for 1 day or less is as effective as longer regimes (Pollard et al 1979, Nelson et al 1983, Wymenga 1991. The prevailing schedule today is 24 hours (Walenkamp 2001).…”

Penetration of Amoxycillin and Clavulanic Acid into Bone

“…It has been shown that the incidence of infection fol lowing this procedure can be significantly reduced by the administration of antibiot ics to cover the operative period [5,6,10,11,14,17]. The main organisms that cause postoperative infection are Staphylococcus aureus, Staphylococcus albus and various gram-negative bacilli [10,12], The anti biotic that is used for prophylaxis must thus be active against all strains of S. au reus as well as against other possible in fecting organisms.…”

“…A wide variety of antibiotics have been studied with regard to their penetration into bone and satisfactory levels appear to be best achieved after parenteral adminis tration of the antibiotic shortly before the operation commences, usually with the in duction of anaesthesia [14,17].…”

Short-Term Administration of Rifampin in the Prevention or Eradication of Infection Due to Foreign Bodies

“…py [7,8], in contrast to the inefficacy of antibiotic therapy initiated after infection has developed, suggests a change in bacterial behavior during the establishment of foreign-body infection.…”