2013
DOI: 10.1016/j.jaip.2013.09.013
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Antibiotic Prophylaxis in Primary Immune Deficiency Disorders

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Cited by 76 publications
(51 citation statements)
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References 105 publications
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“…818 Prophylactic antibiotics and early culture-directed antibiotics were recommended by expert groups. 815,[819][820][821][822][823] Yet there are no consensus guidelines on the use of antibiotics in refractory CRS with immunodeficiency.…”
Section: Because Of Limited Data Crswnp and Crssnp Are Combined In Tmentioning
confidence: 99%
“…818 Prophylactic antibiotics and early culture-directed antibiotics were recommended by expert groups. 815,[819][820][821][822][823] Yet there are no consensus guidelines on the use of antibiotics in refractory CRS with immunodeficiency.…”
Section: Because Of Limited Data Crswnp and Crssnp Are Combined In Tmentioning
confidence: 99%
“…16,[25][26][27][28] Ragab et al 15 compared erythromycin with surgery in 90 patients with CRS and found that both treatments elicited similar improvements in symptom scores and endoscopic findings at follow-up. They suggested that CRS should be treated initially with aggressive medical treatment before a decision is made regarding surgical intervention.…”
Section: Discussionmentioning
confidence: 99%
“…The direct comparison of complement immunodeficiencies in this study highlights the differences in clinical phenotypes, with Pneumococcal disease being the predominant problem in classical pathway defect, indicating the importance of ensuring up to date Pneumococcal vaccination in this subgroup. In contrast, meningococcal disease is less of a problem in classical pathway defects but more common in patients with terminal component defects, emphasising that it is this group where quadrivalent (ACW135Y) conjugate vaccine [37] and group B vaccine [38] as well as supplementary prophylactic antibiotics should be prioritized [39]. The recognition that defects in complement underlie a number of auto-inflammatory diseases leading to acute, or chronic renal failure that can potentially have a poor outcome, even after kidney transplantation highlight the need for physicians to accurately diagnose and develop biologic and stem cell therapies that address the primary pathogenesis if patients are to be treated successfully [40].…”
Section: Discussionmentioning
confidence: 99%