Antibiotic prophylaxis in orthognathic surgery: A 1-day versus 5-day regimen

Bentley, Kenneth C.; Head, Timothy W.; Aiello, George

doi:10.1016/s0278-2391(99)90664-x

Cited by 74 publications

(77 citation statements)

References 21 publications

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“…Los resultados obtenidos en ensayos clínicos aleatorios son controversiales; sin embargo, muestran una tendencia a favor del uso de PA de corta duración 10,11,14,16,23,24 . Los protocolos existentes en distintos centros hospitalarios varían en la administración de antimicrobianos: mientras en algunos hospitales se realiza PA de corta duración, en otros, la PA se extiende, prolongándose hasta por 7 días 25 .…”

Section: Discussionunclassified

“…Antimicrobianos con múltiples dosis post-operatorias (PA de larga duración) 6,7,[9][10][11][13][14][15][16][17][18] . Todo lo anterior cobra importancia en el uso racional de antimicrobianos en los pacientes sometidos a cirugía, lo que conlleva a una disminución de la probabilidad de toxicidad, alergias, sobreinfección y aumento de la resistencia bacteriana.…”

Section: Artículo Originalunclassified

“…En la PA de larga duración, en cambio, se administra además de la dosis pre-operatoria, múltiples dosis post-operatorias prolongándose por más de 24 horas 1,8 . La efi cacia y principios de la PA han sido ampliamente documentados en la literatura médica; sin embargo, su aplicación en cirugía maxilofacial mayor limpiacontaminada es controversial 6,[9][10][11][12][13] . La cirugía maxilofacial clasifi cada como herida limpia-contaminada es aquella con acceso a la cavidad oral y donde no existe infección previa 7 .…”

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Profilaxis antimicrobiana de corta duración versus profilaxis antimicrobiana de larga duración en cirugía maxilofacial mayor limpia-contaminada: Un estudio de cohorte

Villanueva

2012

Rev. chil. infectol.

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AntimicrobianosProfi laxis antimicrobiana de corta duración versus profi laxis antimicrobiana de larga duración en cirugía maxilofacial mayor limpia-contaminada. Un estudio de cohorte Julio Villanueva M., Ignacio Araya C. y Nicolás Yanine M.Short-term antibiotic prophylaxis versus long-term antibiotic prophylaxis in major clean-contaminated maxillofacial surgery.Introduction: There is no consensus on the most appropriate duration of antimicrobial prophylaxis (single or multiple dose) in clean-contaminated maxillofacial surgery. Objective: To determine whether short-term antimicrobial prophylaxis is effective compared to long-term antimicrobial prophylaxis in preventing surgical site infection in clean-contaminated maxillofacial surgery. Patients and Methods: The cohort study included 527 patients. We compared the incidence of surgical site infection in two groups. One group received short-term antibiotic prophylaxis (single dose) and the other group, long-term antimicrobial prophylaxis (multiple dose). Results: The single dose group showed 5.7% of postoperative infections and the multiple-dose group, 5.9%, with an odds ratio of 0.96 (95% CI 0.44 to 2.10) p = 0.9214. Conclusion: No signifi cant differences were found between the infection incidences in the single dose antibiotic prophylaxis group compared with the use of multiple doses.

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Profilaxis antimicrobiana de corta duración versus profilaxis antimicrobiana de larga duración en cirugía maxilofacial mayor limpia-contaminada: Un estudio de cohorte

Villanueva

2012

Rev. chil. infectol.

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“…A penicilina e a clindamicina, utilizadas como profilaxia antibiótica em alguns estudos (Bentley, Head, Aiello, 1999, Chow, 2007Lindeboom, 2006e Jansisyamond, 2008, apresentaram índices de infecção mais elevados (6 a 7%) se comparados aos do HRAC, provavelmente por não estarem associadas a outras drogas necessárias para cobrir uma maior gama de microorganismos.…”

Section: Discussionunclassified

“…A comparação de utilização de antibióticos nas cirurgias por apenas um dia ou sua manutenção por até cinco dias apresentam resultados satisfatórios para ambas as situações (Bentley, Head, Aiello, 1999;Baqain et al 2004;Jansisyamond et.al 2008). Outras formas de administração antibiótica também são observadas nos estudos como na indução anestésica e durante a cirurgia (Spaey et al 2005) bem como no período pré-operatório e durante a cirurgia (Barrier et al 2009;Kang, Yoo, Yi, 2009 No ano seguinte, por meio de uma revisão sistemática foi confirmada uma significante redução do índice de infecção em cirurgias ortognáticas com a aplicação de profilaxia antibiótica, sem se considerar o regime utilizado (Tan et al 2010).…”

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Antibioticoterapia profilática em cirurgia bucomaxilofacial em pacientes com fissuras labiopalatinas

Faco¹

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Evaluation of Prolonged vs Short Courses of Antibiotic Prophylaxis Following Ear, Nose, Throat, and Oral and Maxillofacial Surgery

Oppelaar

Zijtveld

Kuipers

et al. 2019

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Antibiotic prophylaxis is widely used after surgical procedures operating on the mucosal tissues of the aerodigestive tract, but the optimal duration of these prophylactic therapies is often unclear. OBJECTIVE To compare short-course antibiotic prophylaxis (Յ24 hours) vs extended-course antibiotic prophylaxis (Ն72 hours) after ear, nose, throat, and oral and maxillofacial surgery. DATA SOURCES AND STUDY SELECTION Literature searches of PubMed were completed in October 2017 and included prospective trials that compared antibiotic prophylaxis courses of 24 hours or less vs 72 hours or more after ear, nose, throat, and oral and maxillofacial surgery. Some studies were also handpicked from reference lists of studies found with the initial search terms. All analysis was performed between September 2017 and October 2018. DATA EXTRACTION AND SYNTHESIS All review stages were conducted in consensus by 2 reviewers. Data extraction and study quality assessment were performed with the Cochrane data extraction form and the Cochrane risk of bias tool. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used for reporting. The fixed-effects Mantel-Haenszel method was used for meta-analysis. MAIN OUTCOMES AND MEASURES Relative risk (RR) of surgical site infections, microbial origins of surgical site infections, adverse events, duration of hospital stay, and treatment costs. RESULTS Included in the meta-analysis were 21 articles with a cumulative 1974 patients. In patients receiving 24 hours or shorter vs 72 hours or longer antibiotic prophylaxis regimens, no significant difference was found in the occurrence of postoperative infections in the pooled population (RR, 0.90; 95% CI, 0.67-1.19), or in the ear, nose, throat (RR, 0.89; 95% CI, 0.54-1.45), and oral and maxillofacial populations (RR, 0.88; 95% CI, 0.63-1.21), separately. No heterogeneity was observed overall or in the subgroups. Patients receiving extended-course antibiotic prophylaxis were significantly more likely to develop adverse events unrelated to the surgical site (RR, 2.40; 95% CI, 1.20-3.54). CONCLUSIONS AND RELEVANCE No difference was found in the occurrence of postoperative infections between short-course and extended-course antibiotic prophylaxis after ear, nose, throat, and oral and maxillofacial surgery. Therefore, a short course of antibiotic prophylaxis is recommended unless documented conditions are present that would be best treated with an extended course. Using short-course antibiotics could avoid additional adverse events, antibiotic resistance development, and higher hospital costs. Future research should focus on identifying risk groups that might benefit from prolonged prophylaxis.

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Antibiotic prophylaxis in orthognathic surgery: A 1-day versus 5-day regimen

Cited by 74 publications

References 21 publications

Profilaxis antimicrobiana de corta duración versus profilaxis antimicrobiana de larga duración en cirugía maxilofacial mayor limpia-contaminada: Un estudio de cohorte

Profilaxis antimicrobiana de corta duración versus profilaxis antimicrobiana de larga duración en cirugía maxilofacial mayor limpia-contaminada: Un estudio de cohorte

Antibioticoterapia profilática em cirurgia bucomaxilofacial em pacientes com fissuras labiopalatinas

Evaluation of Prolonged vs Short Courses of Antibiotic Prophylaxis Following Ear, Nose, Throat, and Oral and Maxillofacial Surgery

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