Antibiotic prescribing among elderly living in long-term care facilities versus elderly living at home: a Danish registry-based study

Azaizi, Hadir; Jensen, Maria Louise Veimer; Rasmussen, Ida Scheel; Jarloev, Jens Otto; Jensen, J. Steen

doi:10.1080/23744235.2022.2076903

Cited by 1 publication

(1 citation statement)

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“…The elderly population is highly relevant to the study in relation to AMR as it is a high antibiotic-exposure population [ 12 , 13 , 14 ]. This population furthermore has a high rate of hospital admissions and residency at long term care facilities, which both are risk environments for colonization with antimicrobial resistant bacteria and antibiotic treatment [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Prior Antibiotic Use Increases Risk of Urinary Tract Infections Caused by Resistant Escherichia coli among Elderly in Primary Care: A Case-Control Study

et al. 2022

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We investigated whether prior use of antibiotics affects the risk of mecillinam/trimethoprim/nitrofurantoin/multi-resistant Escherichia coli urinary tract infection (UTI) among elderly patients in general practice. Data on urine culture came from urine samples performed in general practice and sent to hospitals in the Capital Region of Denmark, and prescription data came from a nationwide prescription database. The study population consisted of patients with UTI episodes (n = 41,027) caused by E. coli that received a concurrent antibiotic prescription against UTI from 2012 to 2017. We used a case-control design. Cases were UTI episodes caused by mecillinam, trimethoprim, nitrofurantoin or multi-resistant E. coli and controls were UTI episodes caused by E. coli not displaying the respective resistance pattern. We analyzed whether exposure to antibiotics in a period of 8–90 days prior to the UTI episode affected the risk of antibiotic resistant uropathogenic E coli. The analyses were adjusted for age, sex, hospital admission and nursing home status. The odds of resistance to all of the four antibiotics increased significantly after exposure to antibiotics within 90 days prior to the UTI episode. In general, mecillinam showed the lowest increase in the odds for selection of resistance. The results indicate that mecillinam is a favorable antibiotic choice in terms of selection of resistance.

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