Antibiotic noncompliance and waste in upper respiratory infections and acute diarrhea

Reyes, Hortensia; Guiscafré, H; Muñoz, Onofre; Pérez‐Cuevas, Ricardo; Martı́nez, Homero; Gutiérrez, Gonzalo

doi:10.1016/s0895-4356(97)00197-2

Cited by 63 publications

(41 citation statements)

References 36 publications

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“…15 In the 14 estimates involving 7204 participants in whom antibiotics were prescribed for respiratory tract infections, the rate of adherence was slightly higher at 72.6% (95% CI = 65.5 to 79.7). However, there were studies included in this review that included only children, [16][17][18][19] were conducted in resource-poor 17,20,21 or secondary care settings, 7 and/or included small numbers. Furthermore, a number of different methods of measuring and defining adherence were used.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Antibiotics for acute cough: an international observational study of patient adherence in primary care

Francis

Gillespie²,

Nuttall³

et al. 2012

Br J Gen Pract

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BackgroundNon-adherence to acute antibiotic prescriptions is poorly described and may impact on clinical outcomes, healthcare costs, and interpretation of research. It also results in leftover antibiotics that could be used inappropriately. AimTo describe adherence to antibiotics prescribed for adults presenting with acute cough in primary care, factors associated with non-adherence, and associated recovery. Design and settingProspective observational cohort study in general practices in 14 European primary care networks. MethodGPs recorded patient characteristics and prescribing decisions for adults with acute cough or clinical presentation suggestive of lower respiratory tract infection. Patients recorded antibiotic consumption and daily symptoms over 28 days. Rates of adherence to prescribed antibiotics were assessed, and factors associated with non-adherence were identified using logistic regression. Recovery was compared using a Cox proportional hazards model. ResultsOf 2520 patients prescribed immediate or no antibiotics at the index consultation, 282 (11.2%) took an antibiotic during the follow-up period that was not prescribed for them at the index consultation. Of these, 38.1% had no reconsultations during this period. Prior duration of symptoms, antibiotic treatment duration, antibiotic choice, and primary care network were all associated with adherence. There was no difference in time to recovery between those who were prescribed antibiotics at the index consultation and were fully adherent, partially adherent, and non-adherent. ConclusionNon-adherence to antibiotics for acute cough or lower respiratory tract infection is common. Duration of treatment, choice of antibiotic, and setting were associated with adherence but adherence to treatment was not associated with differences in recovery.

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Section: Strengths and Limitationsmentioning

confidence: 99%

Antibiotics for acute cough: an international observational study of patient adherence in primary care

Francis

Gillespie²,

Nuttall³

et al. 2012

Br J Gen Pract

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“…Since many drugs are expensive, some patients purchase incomplete regimens whenever possible and discontinue treatment when the symptoms disappear [209]. As in industrialized countries, unnecessary prescriptions of antibiotics, mainly in cases of acute infantile diarrhea and respiratory infections, have been reported in developing countries [210][211][212][213]. Although the problem is not exclusive to the developing countries, in many hospitals in these regions antibiotic policies and infection control practices are suboptimal, nonexistent, not appropriately enforced or compromised due to the lack of resources and properly trained personnel [214].…”

mentioning

confidence: 99%

Update on Antibacterial Resistance in Low-Income Countries: Factors Favoring the Emergence of Resistance

Vilà

Pál

2010

TOIDJ

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Antimicrobial resistance has increased drastically in recent years in the developing countries, and it has rapidly become a leading public health concern. The prevalence of antimicrobial resistance varies greatly between and within countries and between different pathogens. However, overall a trend to the increase of the resistance to those antimicrobial agents more often used in these countries has been observed. Several factors can contribute to the rapid emergence and dissemination of antimicrobial resistance. In this paper, the current antimicrobial resistance in different microorganisms from different countries as well as the factors contributing to the emergence and spread of resistance in developing countries will be reviewed.

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“…Estos resultados son similares a los de estudios previos que señalan un intervalo de incumplimiento de la terapia antibiótica entre el 40% y el 70% [20][21][22] o, en un intervalo más amplio, del 25 al 82% 15 . Tampoco son diferentes de los de otros estudios españoles que señalan un 60% de incumplimiento del tratamiento en infecciones respiratorias agudas 23 o que lo sitúan por encima del 50% 9,24 . Aunque se ha afirmado que el conocimiento o el nivel de educación no influyen en el cumplimiento terapéutico 13 , en nuestros resultados se ha mostrado que el nivel de estudios de los padres está relacionado con el incumplimiento.…”

Section: Discussionunclassified

Cumplimiento del tratamiento antibiótico en niños en Atención Primaria

et al. 2014

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Antibiotic noncompliance and waste in upper respiratory infections and acute diarrhea

Cited by 63 publications

References 36 publications

Antibiotics for acute cough: an international observational study of patient adherence in primary care

Antibiotics for acute cough: an international observational study of patient adherence in primary care

Update on Antibacterial Resistance in Low-Income Countries: Factors Favoring the Emergence of Resistance

Cumplimiento del tratamiento antibiótico en niños en Atención Primaria

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