Antibiotic-loaded hydroxyapatite scaffolds fabricated from Nile tilapia bones for orthopaedics

Khamkongkaeo, Atchara; Jiamprasertboon, Arreerat; Jinakul, Nanthawan; Srabua, Phatraya; Tantavisut, Saran; Wongrakpanich, Amaraporn

doi:10.1016/j.ijpx.2023.100169

Cited by 2 publications

(1 citation statement)

References 64 publications

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“…PENDAHULUAN Hidroksiapatit (HAp) merupakan biomaterial kalsium fosfat dengan komposisi kimia Ca10(PO4)6(OH)2 yang memiliki struktur heksagonal, identik dengan fase mineral tulang dan jaringan keras manusia (Khamkongkaeo et al, 2023). HAp adalah salah satu bio keramik yang memiliki sifat biokompatibel, biodegradable dan tidak beracun (Siswoyo et al, 2020).…”

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Ekstraksi dan Karakterisasi Hidroksiapatit (HAp) dari Tulang Ikan Tenggiri (Scomberomorus commersoni) dengan Metode Heat Treatment

Purba,

Restianingsih,

Anggraini

et al. 2024

JFU

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Telah dilakukan ekstraksi hidroksiapatit (HAp) dari tulang ikan tenggiri (Scomberomorus commersoni) menggunakan metode heat treatment. Penelitian bertujuan melihat pengaruh suhu yang diberikan kepada sampel terhadap ukuran kristal dan derajat kristalinitas. Heat treatment dilakukan pada suhu 400 ºC, 600 ºC dan 800 ºC masing-masing selama 3 jam terhadap sampel yang telah di preparasi. Hasil analisis XRD menunjukkan adanya puncak yang terbentuk pada sudut 2θ 25,95º; 31,88º; 39,62º; 44,41º; 46,70º; 49,40º untuk suhu 400 ºC, 31,78º; 32,80º; 34,61º pada suhu 600 ºC dan 31,76º; 32,21º; 32,94º; 34,07º pada suhu 800 ºC yang disesuaikan dengan referensi JCPDS 090432. Pada suhu 400 ºC, 600 ºC dan 800 ºC diperoleh ukuran kristal berturut-turut 12,05 nm, 14,18 nm dan 42,55 nm dan derajat kristalinitas bernilai 41,91%, 76,38% dan 87,29%. Spektrum FTIR menunjukkan bahwa, semakin tinggi suhu maka lembah yang terbentuk semakin tajam dan adanya gugus fungsi OH -, CO 3 2− dan PO 4 3− yang merupakan karakteristik dari gugus fungsi HAp, selain itu muncul pula gugus H2O. Karakterisasi SEM menunjukkan morfologi berbentuk bulk.

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Section: Iunclassified

Ekstraksi dan Karakterisasi Hidroksiapatit (HAp) dari Tulang Ikan Tenggiri (Scomberomorus commersoni) dengan Metode Heat Treatment

Purba,

Restianingsih,

Anggraini

et al. 2024

JFU

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Functionalization of Octacalcium Phosphate Bone Graft with Cisplatin and Zoledronic Acid: Physicochemical and Bioactive Properties

Кувшинова

Petrakova

Свиридова

et al. 2023

IJMS

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Bones are the fourth most frequent site of metastasis from malignant tumors, including breast cancer, prostate cancer, melanoma, etc. The bioavailability of bone tissue for chemotherapy drugs is extremely low. This requires a search for new approaches of targeted drug delivery to the tumor growth zone after surgery treatment. The aim of this work was to develop a method for octacalcium phosphate (OCP) bone graft functionalization with the cytostatic drug cisplatin to provide the local release of its therapeutic concentrations into the bone defect. OCP porous ceramic granules (OCP ceramics) were used as a platform for functionalization, and bisphosphonate zoledronic acid was used to mediate the interaction between cisplatin and OCP and enhance their binding strength. The obtained OCP materials were studied using scanning electron and light microscopy, high-performance liquid chromatography, atomic emission spectroscopy, and real-time PCR. In vitro and in vivo studies were performed on normal and tumor cell lines and small laboratory animals. The bioactivity of initial OCP ceramics was explored and the efficiency of OCP functionalization with cisplatin, zoledronic acid, and their combination was evaluated. The kinetics of drug release and changes in ceramics properties after functionalization were studied. It was established that zoledronic acid changed the physicochemical and bioactive properties of OCP ceramics and prolonged cisplatin release from the ceramics. In vitro and in vivo experiments confirmed the biocompatibility, osteoconductivity, and osteoinductivity, as well as cytostatic and antitumor properties of the obtained materials. The use of OCP ceramics functionalized with a cytostatic via the described method seems to be promising in clinics when primary or metastatic tumors of the bone tissue are removed.

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Antibiotic-loaded hydroxyapatite scaffolds fabricated from Nile tilapia bones for orthopaedics

Cited by 2 publications

References 64 publications

Ekstraksi dan Karakterisasi Hidroksiapatit (HAp) dari Tulang Ikan Tenggiri (Scomberomorus commersoni) dengan Metode Heat Treatment

Ekstraksi dan Karakterisasi Hidroksiapatit (HAp) dari Tulang Ikan Tenggiri (Scomberomorus commersoni) dengan Metode Heat Treatment

Functionalization of Octacalcium Phosphate Bone Graft with Cisplatin and Zoledronic Acid: Physicochemical and Bioactive Properties

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