Antibiotic loaded electrospun poly (lactic acid) nanofiber mats for drug delivery system

Suner, Salih Can; Yıldırım, Yeliz; Yurt, Fatma; Ozel, Derya; Oral, Ayhan; Öztürk, İsmail

doi:10.1016/j.jddst.2022.103263

Cited by 15 publications

(8 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to magnesium, some metal ions or atoms, such as silver [19,20], zinc [20] or copper [20][21][22] are also used to give PLA antibacterial properties. In this respect, the bibliography illustrates the use of other dopants of the matrix [13] by reinforcing or by impregnating it [23], such as antibiotics [24,25], surfactants [26][27][28], nanoparticles [29][30][31] and natural biological materials [32,33].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Response to the Surface Aging of PLA Matrices Loaded with Active Compounds

et al. 2022

View full text Add to dashboard Cite

The use of active components in biomaterials improves the properties of existing ones and makes it possible to obtain new devices with antibacterial properties that prevent infections after implantation, thus guaranteeing the success of the implant. In this work, cetyltrimethylammonium bromide (CTAB) and magnesium particles were incorporated into polylactic acid (PLA) films to assess the extent to which progressive aging of the new surfaces resists bacterial colonization processes. For this purpose, the films’ surface was characterized by contact angle measurements, ToF-SIMS and AFM, and adhesion, viability and biofilm growth of Staphylococcus epidermidis bacteria on these films were also evaluated. The results show that the inclusion of Mg and CTAB in PLA films changes their surface properties both before and after aging and also modifies bacterial adhesion on the polymer. Complete bactericidal activity is exhibited on non-degraded films and films with CTAB. This antibacterial behavior is maintained after degradation for three months in the case of films containing a higher amount of CTAB.

show abstract

Section: Introductionmentioning

confidence: 99%

Bacterial Response to the Surface Aging of PLA Matrices Loaded with Active Compounds

et al. 2022

View full text Add to dashboard Cite

show abstract

“…At the same time, if the solution parameters are chosen well, the biomolecule is above all protected by a polymer matrix and, thus, the possible structural changes and activity limitations of the molecule due to the effect of high voltage are minimized. It has been proven that the kinetic profile of antibiotic release from the nanofibrous network was mostly gradual compared to the tablets, and their distribution to the site of action is more efficient in the long term, as the minimum effective concentration parameter is maintained throughout the therapy [ 152 , 153 ]. A selection of successfully incorporated antibiotics in nanofibrous carriers is summarized in Table 9 .…”

Section: Organic Antimicrobial Agentsmentioning

confidence: 99%

Trends in the Incorporation of Antiseptics into Natural Polymer-Based Nanofibrous Mats

Piskláková,

Skuhrovcová,

Bártová

et al. 2024

Polymers

View full text Add to dashboard Cite

Nanofibrous materials represent a very promising form of advanced carrier systems that can be used industrially, especially in regenerative medicine as highly functional bandages, or advanced wound dressings. By incorporation of antimicrobial additives directly into the structure of the nanofiber carrier, the functionality of the layer is upgraded, depending on the final requirement—bactericidal, bacteriostatic, antiseptic, or a generally antimicrobial effect. Such highly functional nanofibrous layers can be prepared mostly by electrospinning technology from both synthetic and natural polymers. The presence of a natural polymer in the composition is very advantageous. Especially in medical applications where, due to the presence of the material close to the human body, the healing process is more efficient and without the occurrence of an unwanted inflammatory response. However, converting natural polymers into nanofibrous form, with a homogeneously distributed and stable additive, is a great challenge. Thus, a combination of natural and synthetic materials is often used. This review clearly summarizes the issue of the incorporation and effectiveness of different types of antimicrobial substances, such as nanoparticles, antibiotics, common antiseptics, or substances of natural origin, into electrospun nanofibrous layers made of mostly natural polymer materials. A section describing the problematic aspects of antimicrobial polymers is also included.

show abstract

“…Various types of antimicrobial release devices, such as hydrogels, , nanoparticles (NPs), , micro/nanofibers, , and film-based reservoir devices, , have been proposed. Among them, pulsatile antibiotic delivery systems using external electrical stimulation signals have drawn attention, as they allow repeatable and reliable drug release flux for therapeutic needs, thereby allowing remote control of local drug administration.…”

Section: Introductionmentioning

confidence: 99%

Electroresponsive and pH-Sensitive Hydrogel as Carrier for Controlled Chloramphenicol Release

et al. 2023

View full text Add to dashboard Cite

Multiresponsive hydrogels, which are smart soft materials that respond to more than one external stimulus, have emerged as powerful tools for biomedical applications, such as drug delivery. Within this context and with the aim of eliminating the systematic administration of antibiotics, special attention is being paid to the development of systems for controlled delivery of antibiotic for topical treatment of bacterial infections. In this work, an electro-chemo responsive hydrogel able to release chloramphenicol (CAM), a broad spectrum antibiotic also used for anticancer therapy, is proposed. This has been prepared by grafting poly(acrylic acid) (PAA) to sodium alginate (Alg) and in situ encapsulation of poly(3,4-ethylenedioxythiophene) nanoparticles loaded with CAM (PEDOT/CAM NPs), which were obtained by emulsion polymerization. Although the response to electrical stimuli of PEDOT was the main control for the release of CAM from PEDOT/ CAM NPs, the release by passive diffusion had a relatively important contribution. Conversely, the passive release of antibiotic from the whole engineered hydrogel system, Alg-g-PAA/PEDOT/CAM, was negligible, whereas significant release was achieved under electrostimulation in an acid environment. Bacterial tests and assays with cancer cells demonstrated that the biological activity of CAM remained after release by electrical stimulation. Notably, the successful dual-response of the developed hydrogel to electrical stimuli and pH changes evidence the great prospect of this smart material in the biomedical field, as a tool to fight against bacterial infections and to provide local cancer treatment.

show abstract

Antibiotic loaded electrospun poly (lactic acid) nanofiber mats for drug delivery system

Cited by 15 publications

References 49 publications

Bacterial Response to the Surface Aging of PLA Matrices Loaded with Active Compounds

Bacterial Response to the Surface Aging of PLA Matrices Loaded with Active Compounds

Trends in the Incorporation of Antiseptics into Natural Polymer-Based Nanofibrous Mats

Electroresponsive and pH-Sensitive Hydrogel as Carrier for Controlled Chloramphenicol Release

Contact Info

Product

Resources

About