Antibiotic growth promoters in agriculture: history and mode of action

Dibner, J. J.; Richards, J. D.

doi:10.1093/ps/84.4.634

Cited by 1,079 publications

(854 citation statements)

References 62 publications

Supporting

Mentioning

753

Contrasting

Unclassified

Order By: Relevance

“…It is generally accepted that the bacterial species inhabiting the gut compete for the nutrients with the host, which results in an higher energy uptake (Furuse and Yokota, 1985). Moreover, intestinal microflora requires increased mucus secretion and epithelial cells turnover in the guts, which is accompanied by an extremely high rate of metabolism and protein synthesis, resulting in 23% to 36% of the whole body energy expenditure (Dibner and Richards, 2005).…”

Section: Discussionmentioning

confidence: 99%

Influence of different prebiotics and mode of their administration on broiler chicken performance

Bednarczyk

Stadnicka

Kozłowska

et al. 2016

Animal

View full text Add to dashboard Cite

In the post-antibiotics era, prebiotics are proposed as alternatives to antibiotic growth promoters in poultry production. The goal of this study was to compare in ovo method of prebiotic delivery with in-water supplementation and with both methods combined ( in ovo + in-water) in broiler chickens. Two trials were conducted. Trial 1 was carried out to optimize the doses of two prebiotics, DN (DiNovo ® , extract of beta-glucans) and BI (Bi 2 tos, trans-galactooligosaccharides), for in ovo delivery. The estimated parameters were hatchability and bacteriological status of the newly hatched chicks. Prebiotics were dissolved in 0.2 ml of physiological saline, at the doses: 0.18, 0.88, 3.5 and 7.0 mg/embryo; control group (C) was injected in ovo with 0.2 ml of physiological saline. Trial 2 was conducted to evaluate effects of different prebiotics (DN, BI and raffinose family oligosaccharides (RFO)) delivered in ovo, in-water and in a combined way ( in ovo + in-water) on broiler chickens performance. The results of the Trial 1 indicated that the optimal dose of DN and BI prebiotics delivered in ovo, that did not reduce chicks' hatchability, was 0.88 mg/embryo (DN) and 3.5 mg/embryo (BI). Both prebiotics numerically increased number of lactobacilli and bifidobacteria in chicken feces ( P > 0.05). In Trial 2, all prebiotics (DN, BI and RFO) significantly increased BW gain compared with the C group ( P < 0.05), especially during the first 21 days of life. However, feed intake and feed conversion ratio were increased upon prebiotics delivery irrespective of method used. Injection of prebiotics in ovo combined with in-water supplementation did not express synergistic effects on broilers performance compared with in ovo injection only. Taken together, those results confirm that single in ovo prebiotics injection into the chicken embryo can successfully replace prolonged in-water supplementation post hatching.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of different prebiotics and mode of their administration on broiler chicken performance

Bednarczyk

Stadnicka

Kozłowska

et al. 2016

Animal

View full text Add to dashboard Cite

show abstract

“…This practice began in the USA and then Europe in the 1950s (Dibner & Richards, 2005) and although the mechanism of growth promotion was -and still is -not fully understood, it became widely utilised in the UK and elsewhere. In 1960, the Agricultural and Medical Research Councils set up a committee, chaired by Lord Netherthorpe, to investigate possible risks from antibiotic feed additives for human and animal health -the report published in 1962 found no persuasive evidence for concern.…”

Section: Amr and The Governance Of Antibiotic Use In Agriculturementioning

confidence: 99%

Framing the agricultural use of antibiotics and antimicrobial resistance in UK national newspapers and the farming press

Morris

Helliwell

Raman

2016

Journal of Rural Studies

View full text Add to dashboard Cite

The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Common to all frames is that the relationship between agricultural use of antibiotics and problems posed by AMR is mostly discussed in terms of the implications for human health as opposed to both human and animal health.

show abstract

“…Perceptions of consumers on raw and cooked meat quality have created significant interest in increasing the understanding of digestive physiology and the dynamics of the gut microflora (Dibner & Richards, 2005). Physiological studies reveal that a functional gastrointestinal tract (GIT) is vital for the digestion and absorption of nutrients required for the bird's maintenance and growth (Mateos et al, 2002;Baurhoo et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Intestinal morphology, digestive organ size and digesta pH of broiler chickens fed diets supplemented with or without <i>Moringa oleifera</i> leaf meal

Nkukwana¹,

Muchenje²,

Masika³

et al. 2015

SA J. An. Sci.

View full text Add to dashboard Cite

The intestinal morphology and pH of digesta of broiler chickens at 35 days old were studied. Birds were reared on these dietary treatments (T). T1, positive control, contained 668 g salinomycin and 500 g zinc bacitracin per kg of feed. Treatments, T2, T3 and T4, contained graded levels of Moringa oleifera leaf meal (MOLM) per kg of feed, namely starter (1, 3, 5 g), grower (3, 9, 15 g) and finisher (5, 15, 25 g). T5 was a negative control (without supplementation). Birds were provided feed and water ad libitum. Birds in T3 had the highest proventriculus digesta pH, and T5 birds the lowest. Birds that were supplemented with MOLMand surprisingly those from the negative control -had significantly higher caecal digesta pH, while T1 had the highest ileal digesta pH. Duodenal villous length was longest in T2, and shortest in T4. Jejunal villous length was longest in T3 and shortest in T2 birds. T3 and T4 jejunal villi were widest, with T1 birds having the shortest. Ileal villous was longest in T2 and T5 birds, while T3 birds had the shortest. Duodenal surface area for absorption was larger in T2 and T5, and smaller in T4, while T3 had the largest ileal surface area, and T1 the smallest. The jejunal surface area was largest in T3 (53.2) and T4 (50.7), and smallest in T1 (25.0). The current results reveal a regulatory effect of MOLM on the gastrointestinal tract, which could be attributed to the coarseness of the diets, thus raising the pH and resulting in thicker digesta viscosity, which is a clear sign of a healthy gut. ______________________________________________________________________________________

show abstract

Antibiotic growth promoters in agriculture: history and mode of action

Cited by 1,079 publications

References 62 publications

Influence of different prebiotics and mode of their administration on broiler chicken performance

Influence of different prebiotics and mode of their administration on broiler chicken performance

Framing the agricultural use of antibiotics and antimicrobial resistance in UK national newspapers and the farming press

Intestinal morphology, digestive organ size and digesta pH of broiler chickens fed diets supplemented with or without <i>Moringa oleifera</i> leaf meal

Contact Info

Product

Resources

About