Antibiotic-free composite bone cements with antibacterial and bioactive properties. A preliminary study

Miola, Marta; Bruno, Matteo; Maina, Giovanni; Fucale, Giacomo; Lucchetta, Giovanni; Verné, Enrica

doi:10.1016/j.msec.2014.06.026

Cited by 43 publications

(35 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highest compressive strength (89 MPa) was reached by cements having very low viscosity, even though the values were not statistically different, as also observed by authors in other reports [ 39 ]. This preliminary mechanical characterization demonstrates that the addition of 10% inorganic phase did not modify the compression strength of cements, as already observed by authors for different composite cement compositions [ 37 , 38 , 39 ]. Thus, this provides an important starting point for future mechanical evaluation, such as bending and fatigue strength characterization.…”

Section: Resultssupporting

confidence: 85%

“…Nevertheless, Moojen et al stated that bone cements containing silver (Ag) nanoparticles were not effective in preventing in vivo infections [ 35 ]. Authors proposed an innovative solution by incorporating bioactive and Ag-doped glass powders in PMMA bone cements, thus creating a composite bone cement that is also bioactive and antibacterial without the use of antibiotics [ 36 , 37 , 38 , 39 ]. Furthermore, the addition of a single phase, having both bioactive and antibacterial properties, allowed the maintenance of mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization

et al. 2018

Self Cite

View full text Add to dashboard Cite

To promote osteointegration and simultaneously limit bacterial contamination without using antibiotics, we designed innovative composite cements containing copper (Cu)-doped bioactive glass powders. Cu-doped glass powders were produced by a melt and quenching process, followed by an ion-exchange process in a Cu salt aqueous solution. Cu-doped glass was incorporated into commercial polymethyl methacrylate (PMMA)-based cements with different viscosities. The realized composites were characterized in terms of morphology, composition, leaching ability, bioactivity, mechanical, and antibacterial properties. Glass powders appeared well distributed and exposed on the PMMA surface. Composite cements showed good bioactivity, evidencing hydroxyapatite precipitation on the sample surfaces after seven days of immersion in simulated body fluid. The leaching test demonstrated that composite cements released a significant amount of copper, with a noticeable antibacterial effect toward Staphylococcus epidermidis strain. Thus, the proposed materials represent an innovative and multifunctional tool for orthopedic prostheses fixation, temporary prostheses, and spinal surgery.

show abstract

Section: Resultssupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…2, 5 After the bacterial proliferation periods, the infections associated with the implants can hardly be cured by traditional systemic antibiotic therapy due to the formation of biofilms 1 . The biofilms can also protect the bacteria against human defense system 2 . It was reported that the infection rate in orthopedic and trauma surgeries for open fracture could be up to about 1% and 12–53%, respectively.…”

Section: Introductionmentioning

confidence: 99%

Addition of Zn to the ternary Mg–Ca–Sr alloys significantly improves their antibacterial properties

Zhang

et al. 2015

J. Mater. Chem. B

View full text Add to dashboard Cite

Most of the magnesium (Mg) alloys possess excellent biocompatibility, mechanical property and biodegradability in orthopedic applications. However, these alloys may suffer from bacterial infections due to their insufficient antibacterial capability. In order to reduce the post-surgical infections, a series of biocompatible Mg–1Ca-0.5Sr-xZn (x=0, 2, 4, 6) alloys were fabricated with the addition of antibacterial Zn with variable content and evaluated in terms of their biocompatibility and antibacterial property. The in vitro corrosion study showed that Mg-1Ca-0.5Sr-6Zn alloys exhibited a higher hydrogen evolution volume after 100 h immersion and resulted in a higher pH value of the immersion solution. Our work indicated that Zn-containing Mg alloys exhibited good biocompatibility with high cell viability. The antibacterial studies reveal that the number of bacteria adhered on all of these Mg alloy samples diminished remarkably compared to the Ti-6Al-4V control group. We also found that the proliferation of the bacteria was inhibited by these Mg alloys extracts. Among the prepared alloys, Mg-1Ca-0.5Sr-6Zn alloy not only exhibited a strong antibacterial effect, but also promoted the proliferation of MC3T3-E1 osteoblasts, suggesting that it is a promising alloy with both good antibacterial property and good biocompatibility for use as an orthopedic implant.

show abstract

“…In the literature, only a few studies were found that concerned the bactericidal activity of bone cements modified with nanometals, mainly with nanosilver. In the case of bone cements, the main conclusions suggested that only bacteriostatic properties were found and bactericidal activity was not detected (Miola et al, ; Moojen et al, ; Paiva et al, ; Petrochenko et al, ; Slane, Vivanco, Rose, Ploeg, & Squire, ). In our research, the bacterial growth inhibition zone occurred and it oscillated around 15 mm (after 7 days).…”

Section: Discussionmentioning

confidence: 99%

“…In the case of infection risk, the use of bioactive cement (with an antibiotic or nanometals) is suggested. On the basis of own research and literature (Miola et al, ; Moojen et al, ; Paiva et al, ; Petrochenko et al, ; Slane et al, ; Świeczko‐Żurek, ; Wekwejt et al, ), the following conclusions have been drawn: antibiotics worsen the mechanical properties, while nanometals have no negative effect on them; in the case of antibiotics, there is a problem of bacterial resistance and lack of therapeutic efficacy; however, in the case of nanometals, dose selection is crucial because of their cytotoxicity. Moreover, a significant problem in both cases is to provide a long period of protection, which depends on the release of the active substance.…”

Section: Discussionmentioning

confidence: 99%

Implant system for treatment of the orbital floor defects of blowout fractures in the maxillofacial region using polypropylene yarn and bioactive bone cement

et al. 2020

View full text Add to dashboard Cite

Fractures in the craniofacial region are a serious problem in terms of treatment. The most reasonable solution is the use of individual implants dedicated to a specific patient. The aim of this study was to develop the implant system specifically for treatment of the orbital floor defects of blowout fractures of maxillofacial region, using polypropylene yarn and bone cement. Three types of bone cement were used to fix the polypropylene yarn: unmodified, antibiotic‐loaded, and modified with nanometals. The following research was carried out: selection of cement production parameters, assessment of the curing time, measurement of polymerization temperature, an analysis of microstructure and surface topography, evaluation of wettability, measurement of microhardness, and studies of bactericidal effectiveness. The research confirms the possibility of using bone cement and polypropylene yarn for an individual implant, dedicated to the fractures treatment in the maxillofacial region. Moreover, the bactericidal properties of the proposed modifications for bone cement have been verified; hence, bioactive cements are recommended for use in the case of infectious complications.

show abstract

Antibiotic-free composite bone cements with antibacterial and bioactive properties. A preliminary study

Cited by 43 publications

References 29 publications

Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization

Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization

Addition of Zn to the ternary Mg–Ca–Sr alloys significantly improves their antibacterial properties

Implant system for treatment of the orbital floor defects of blowout fractures in the maxillofacial region using polypropylene yarn and bioactive bone cement

Contact Info

Product

Resources

About