Antibiotic embedded absorbable prosthesis for prevention of surgical mesh infection: experimental study in rats

Suárez-Grau, Juan Manuel; Morales-Conde, Salvador; Galán, Verónica González; Cartes, J. A. Martín; Durántez, Fernando Docobo; Padillo-Ruíz, Javier

doi:10.1007/s10029-014-1334-5

Cited by 18 publications

(13 citation statements)

References 18 publications

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“…Antimicrobial meshes can be made by dipping/soaking, plasma surface functionalization, plasma-induced graft polymerization [216] (see Figure 3). The antibiotic dipping/soaking method [217][218][219][220], antiseptics [221] and enzymes [222,223] dissolved in a liquid solution (usually aqueous) that are physically adsorbed onto the mesh. This technique, while useful, has not demonstrated clinical superiority over systemic antibiotic therapy.…”

Section: Antimicrobial Meshes and Their Fabrication Methodsmentioning

confidence: 99%

“…Prior to the clinical translation of these meshes, further studies including long-term evaluation and biocompatibility studies are needed. Other meshes that have already shown an evident decrease in bacterial colonization of the Gram-positive S. aureus are prostheses impregnated with the antibiotic cefazolin [220]. Although adhesions to the prosthesis were produced when it was placed in contact with intra-abdominal viscera, the antibiotic mesh reduced the formation of adhesions compared with the control group, besides inhibiting the inflammatory response to infection [220].…”

Section: Meshes With Antibioticsmentioning

confidence: 99%

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Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Serrano‐Aroca¹,

Pous‐Serrano²

2021

Preprint

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Worldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons working in this area classified according to their biological or chemical nature, morphology and whether bioabsorbable or not. We emphasise the importance of surgical site infection in herniatology, how to deal with this microbial problem, and we go further into the future research lines on the production of advanced antimicrobial meshes to improve hernia repair and prevent microbial infections, including multidrug-resistant strains. A great deal of progress has been made in this biomedical field in the last decade. However, we are still far from an ideal antimicrobial mesh that can also provide excellent integration to the abdominal wall, mechanical performance, low visceral adhesion and minimal inflammatory or foreign body reactions, among many other problems.

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Section: Antimicrobial Meshes and Their Fabrication Methodsmentioning

confidence: 99%

Section: Meshes With Antibioticsmentioning

confidence: 99%

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Serrano‐Aroca¹,

Pous‐Serrano²

2021

Preprint

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“…The loading efficiency was estimated to be around 0.10e0.20 mg/cm 2 of prosthesis, which was sufficient to prevent contamination in an infected rabbit model [81]. Nonspecific physical adsorption of antibiotics [81,88,96,100], antiseptics [103] and enzymes [112,116] were reported by dipping or soaking aqueous solution containing the therapeutics directly on the meshes. Under such condition, the amount of antibacterial compound loaded depends mainly on the fluid adsorption capability of the mesh substrate.…”

Section: Dipping/soakingmentioning

confidence: 99%

Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?

Guillaume

Pérez‐Tanoira

Fortelny³

et al. 2018

Biomaterials

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The incidence of mesh-related infection after abdominal wall hernia repair is low, generally between 1 and 4%; however, worldwide, this corresponds to tens of thousands of difficult cases to treat annually. Adopting best practices in prevention is one of the keys to reduce the incidence of mesh-related infection. Once the infection is established, however, only a limited number of options are available that provides an efficient and successful treatment outcome. Over the past few years, there has been a tremendous amount of research dedicated to the functionalization of prosthetic meshes with antimicrobial properties, with some receiving regulatory approval and are currently available for clinical use. In this context, it is important to review the clinical importance of mesh infection, its risk factors, prophylaxis and pathogenicity. In addition, we give an overview of the main functionalization approaches that have been applied on meshes to confer anti-bacterial protection, the respective benefits and limitations, and finally some relevant future directions.

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“…It was observed that impregnation of the mesh with cefazolin prevents the infection of the prosthesis placed in infected wound [95].…”

Section: Mesh Modificationsmentioning

confidence: 99%

Innovative Modifications for Preventing Mesh Infections

Aydınuraz¹

2017

J Microb Biochem Technol

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Antibiotic embedded absorbable prosthesis for prevention of surgical mesh infection: experimental study in rats

Cited by 18 publications

References 18 publications

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?

Innovative Modifications for Preventing Mesh Infections

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