Antibiotic duration for treating uncomplicated, symptomatic lower urinary tract infections in elderly women

Lutters, Monika; Vogt-Ferrier, NB

doi:10.1002/14651858.cd001535

Cited by 50 publications

(50 citation statements)

References 144 publications

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“…Studies have looked to find the optimal length of therapy222324 but potential treatment durations are based on empirical evidence. This study used a mathematical model as a way to determine the time to eradication of the infection and therefore the minimum duration of treatment required.…”

Section: Discussionmentioning

confidence: 99%

Optimising Antibiotic Usage to Treat Bacterial Infections

Paterson

Hoyle

Ochoa

et al. 2016

Sci Rep

100

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The increase in antibiotic resistant bacteria poses a threat to the continued use of antibiotics to treat bacterial infections. The overuse and misuse of antibiotics has been identified as a significant driver in the emergence of resistance. Finding optimal treatment regimens is therefore critical in ensuring the prolonged effectiveness of these antibiotics. This study uses mathematical modelling to analyse the effect traditional treatment regimens have on the dynamics of a bacterial infection. Using a novel approach, a genetic algorithm, the study then identifies improved treatment regimens. Using a single antibiotic the genetic algorithm identifies regimens which minimise the amount of antibiotic used while maximising bacterial eradication. Although exact treatments are highly dependent on parameter values and initial bacterial load, a significant common trend is identified throughout the results. A treatment regimen consisting of a high initial dose followed by an extended tapering of doses is found to optimise the use of antibiotics. This consistently improves the success of eradicating infections, uses less antibiotic than traditional regimens and reduces the time to eradication. The use of genetic algorithms to optimise treatment regimens enables an extensive search of possible regimens, with previous regimens directing the search into regions of better performance.

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Section: Discussionmentioning

confidence: 99%

Optimising Antibiotic Usage to Treat Bacterial Infections

Paterson

Hoyle

Ochoa

et al. 2016

Sci Rep

100

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“…In addition, three meta-analyses on general aspects of antibiotic therapy for acute uncomplicated cystitis [4][5][6] and one recently published meta-analysis on antibiotic versus placebo treatment of women with uncomplicated cystitis [7] were also considered. The studies were rated according to the level of evidence (LoE) and the grade of recommendation (GoR) using ICUD standards (for details see Preface) [8,9].…”

Section: Methodsmentioning

confidence: 99%

Antibiotic treatment of uncomplicated urinary tract infection in premenopausal women

Naber

Wullt

Wagenlehner

2011

International Journal of Antimicrobial Agents

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“…Longer-thanneeded durations are one of the most frequent causes of unnecessary antibiotic prescriptions [14]. Several authors have shown that around half of systemic antibiotic courses in LTCFs are longer than 7 days [8,10,30], and this appeared to be influenced by prescriber preference more than patient characteristics, even though 7 days of therapy is sufficient for the most common bacterial infections encountered in LTCF residents [62][63][64].…”

Section: Target Areas Where Antibiotic Misuse Is Commonmentioning

confidence: 99%

Strategies and challenges of antimicrobial stewardship in long-term care facilities

Dyar

Pagani

Pulcini

2015

Clinical Microbiology and Infection

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As people are living longer the demand for long-term care facilities (LTCFs) continues to rise. For many reasons, antimicrobials are used intensively in LTCFs, with up to a half of this use considered inappropriate or unnecessary. Over-use of antimicrobials can have direct adverse consequences for LTCF residents and promotes the development and spread of resistant bacteria. It is therefore critical that LTCFs are able to engage in antimicrobial stewardship programmes, which have the potential to minimize the antibiotic selective pressure, while improving the quality of care received by LTCF residents. To date, no antimicrobial stewardship guidelines specific to LTCF settings have been published. Here we outline the scale of antimicrobial use in LTCFs and the underlying drivers for antibiotic over-use. We further describe the particular challenges of antimicrobial stewardship in LTCFs, and review the interventional studies that have aimed to improve antibiotic use in these settings. Practical recommendations are then drawn from this research to help guide the development and implementation of antimicrobial stewardship programmes.

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Antibiotic duration for treating uncomplicated, symptomatic lower urinary tract infections in elderly women

Abstract: Cochrane Database of Systematic Reviews

Cited by 50 publications

References 144 publications

Optimising Antibiotic Usage to Treat Bacterial Infections

Optimising Antibiotic Usage to Treat Bacterial Infections

Antibiotic treatment of uncomplicated urinary tract infection in premenopausal women

Strategies and challenges of antimicrobial stewardship in long-term care facilities

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