Antibiotic drug release behavior of poly (vinyl alcohol)/sodium alginate hydrogels

Xie, Liang; Wei, Hongyuan; Kou, Lvheng; Ren, Liming; Zhou, Jiang

doi:10.1002/mawe.201900163

Cited by 26 publications

(19 citation statements)

References 17 publications

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“…In recent studies, antimicrobial CAM was encapsulated in nonelectroresponsive polymeric carriers for release. [ 26–28 ] For example, CAM‐loaded polycaprolactone (PCL) nanofibers and, especially, PCL‐ polyethylene oxide (PEO) and microfiber exhibited a very fast release in PBS, reaching in 1 h more than 30% and 90%, respectively. [ 26 ] The difference between such two systems was attributed to the hydrophobic and hydrophilic nature of PCL and PCL‐PEO fibers, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…In any case, the strength of the interaction between CAM and such polymers was significantly weaker than with PEDOT. Similarly, the release of CAM loaded in poly(vinyl alcohol)/sodium alginate hydrogels was very high, independently of the ratio between such two polymers, reaching more than 50% in less than 3 h. [ 27 ] Similarly, CAM was easily released from both loaded amorphous calcium phosphate and hydroxyapatite nanoparticles in the simple physiological PBS medium. [ 28 ] Overall, these observations support the strength of CAM⋅⋅⋅PEDOT interactions.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Nanotheranostic Interface Based on Antibiotic‐Loaded Conducting Polymer Nanoparticles for Real‐Time Monitoring of Bacterial Growth Inhibition

Enshaei

Puiggalı́-Jou

Valle

et al. 2020

Adv Healthcare Materials

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Conducting polymers have been increasingly used as biologically interfacing electrodes for biomedical applications due to their excellent and fast electrochemical response, reversible doping–dedoping characteristics, high stability, easy processability, and biocompatibility. These advantageous properties can be used for the rapid detection and eradication of infections associated to bacterial growth since these are a tremendous burden for individual patients as well as the global healthcare system. Herein, a smart nanotheranostic electroresponsive platform, which consists of chloramphenicol (CAM)‐loaded in poly(3,4‐ethylendioxythiophene) nanoparticles (PEDOT/CAM NPs) for concurrent release of the antibiotic and real‐time monitoring of bacterial growth is presented. PEDOT/CAM NPs, with an antibiotic loading content of 11.9 ± 1.3% w/w, are proved to inhibit the growth of Escherichia coli and Streptococcus sanguinis due to the antibiotic release by cyclic voltammetry. Furthermore, in situ monitoring of bacterial activity is achieved through the electrochemical detection of β‐nicotinamide adenine dinucleotide, a redox active specie produced by the microbial metabolism that diffuse to the extracellular medium. According to these results, the proposed nanotheranostic platform has great potential for real‐time monitoring of the response of bacteria to the released antibiotic, contributing to the evolution of the personalized medicine.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nanotheranostic Interface Based on Antibiotic‐Loaded Conducting Polymer Nanoparticles for Real‐Time Monitoring of Bacterial Growth Inhibition

Enshaei

Puiggalı́-Jou

Valle

et al. 2020

Adv Healthcare Materials

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“…Thus, releasing of chloramphenicol from the loaded КC/SA/K + hydrogel is achieved only at pH 4.1 and shown in Figure 9. It is clear that the released drug quantity reached a constant value after about 3 hours, which can be interpreted in terms of the beaded hydrogel structure as well as the repulsive electrostatic interactions between the protonated acidic groups in the formed gel structure at pH 4.1 and the drug molecules that ultimately facilitate the releasing of such drug 51,52 …”

Section: Resultsmentioning

confidence: 99%

К‐carrageenan/Na‐alginate wound dressing with sustainable drug delivery properties

Fahmy¹,

Aly²,

Sayed³

et al. 2021

Polymers for Advanced Techs

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Despite К‐carrageenan (КC) merits as a biopolymer convenient for versatile medical applications, it exhibits limitations in processability and reactivity. To overcome such limitations, КC, in this study, was blended with Na‐alginate (SA) in different weight ratios and cross‐linked with potassium ions. The swelling and gel fraction properties demonstrate that the cross‐linked КC/SA matrix of a ratio of 66.7% is suitable to be applied as a topical wound dressing. Characterization of the prepared КC/SA/K+ gel film was performed using scanning electron microscope as well as FTIR. The in vitro release of chloramphenicol as a drug model from the nominated loaded film at pH 4.1 reached a constant value after about 3 hours. To enhance the antibacterial properties of the КC/SA/K+ film, silver nanoparticles as bioactive additive were loaded in combination with chloramphenicol, and the antibacterial properties of the loaded film were evaluated, and showed high antibacterial properties against both Gram‐positive and Gram‐negative bacteria.

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“…Polymer hydrogels evaluated were blends of poly(vinyl alcohol) (PVA), sodium alginate (Alg), and chitosan (Ch). Cross-linking agents included CaCl 2 , boric acid, and NaOH . Data were collected in triplicate using a custom, student assembled pH measurement instrument called a “GelipHish” (build instructions in the Supporting Information (SI)).…”

Section: Discussionmentioning

confidence: 99%

Implementing the Elements of Course-Based Undergraduate Research Experiences (CUREs) in a First-Year Undergraduate Chemistry Laboratory with Bioremediation Relevance

et al. 2022

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General chemistry laboratories are a core requirement for nearly all STEM (Science, Technology, Engineering, and Mathematics) majors and have the greatest breadth in disciplines and audience of any STEM course at a university. A bioremediation Course-based Undergraduate Research Experience (CURE) for first-year undergraduate students was developed to capture and engage student interest for this diverse group. In this multiweek laboratory exercise, students joined an NSF-funded research project designed to enhance the bioremediation of chlorinated aliphatic hydrocarbons. Students explored various biocompatible polymer blends and cross-linkers for encapsulation to create protection for bioremediation microbes. In this “guided research” model, students constructed the measurement apparatus, made hydrogel blends, and then monitored the diffusion of acid via pH measurements using a custom instrument. Herein, we describe how CURE elements were implemented within the bioremediation research experience culminating in student teams presenting posters at our university’s undergraduate research symposium. An open-laboratory format facilitated an active research group experience and recitation “group meeting” provided flexibility and needed time for reflection and discussion. Student survey data and course evaluations indicated that students saw value in this genuine research experience and enjoyed the freedom and time to practice and hone skills as both a scientist and teammate in a laboratory setting.

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Antibiotic drug release behavior of poly (vinyl alcohol)/sodium alginate hydrogels

Cited by 26 publications

References 17 publications

Nanotheranostic Interface Based on Antibiotic‐Loaded Conducting Polymer Nanoparticles for Real‐Time Monitoring of Bacterial Growth Inhibition

Nanotheranostic Interface Based on Antibiotic‐Loaded Conducting Polymer Nanoparticles for Real‐Time Monitoring of Bacterial Growth Inhibition

К‐carrageenan/Na‐alginate wound dressing with sustainable drug delivery properties

Implementing the Elements of Course-Based Undergraduate Research Experiences (CUREs) in a First-Year Undergraduate Chemistry Laboratory with Bioremediation Relevance

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