Antibiotic consumption study in two hospitals in Asmara from 2014 to 2018 using WHO’s defined daily dose (DDD) methodology

Abstract

This study compares the antibiotic consumption rates over a period of five years in two hospitals in Eritrea, Orotta National Referral and Teaching Hospital (ONRTH) and Hazhaz Zonal Referral Hospital (HZRH). Antibiotic consumption is an important parameter in the study of antibiotic use. However, no published data on consumption rates exist for these two hospitals, thus the aim of the study is to measure and compare a five year antibiotic consumption trends of the two hospitals' medical wards using Defined Daily Dose per 100 beddays (DDD/100-BD). Antibiotics dispensed from January 2014 to December 2018 were considered. Non-parametric Pearson's correlation coefficient was used for comparison of consumption, while non-parametric Friedman's test measured annual rates. The total antibiotic consumption in the HZRH was almost double that of ONRTH. The analysis showed that antibiotic consumption in ONRTH was significantly decreased from 2014 to 2018 while there was no significant difference in consumption in HZRH. Benzyl penicillin was the most consumed antibiotic in HZRH and ONRTH throughout the study period at 87.8DDD/100-BD and 35.4 DDD/100-BD respectively. Ceftriaxone and ciprofloxacin were among the most commonly consumed antibiotics in both hospitals. Establishment of Antibiotic stewardship program would benefit both hospitals greatly, and further studies need to be done to establish the national antibiotic consumption baseline.

Antibiotic utilization study in a teaching hospital in Nigeria

“…in Asmara, Eritrea. 26 However, it was inconsistent with a study by Gutema et al ., 10 who conducted a study in three medical wards of one of the largest tertiary hospitals in Ethiopia and reported that their antibiotic consumption was 91.8 DDD/100 bed-days. The higher figure obtained in this study reflects the large number of antibiotics that are being used in our hospitals.…”

Antibiotic consumption and time to recovery from uncomplicated urinary tract infection: secondary analysis of observational data from a point-of-care test trial

“…Patients were categorised into two groups: whether they consumed any antibiotic during follow-up or not. A standardised antibiotic consumption unit (standardised antibiotic days) was implemented to allow comparison between different antibiotic strengths and dosing regimens (17)(18)(19). Consumption ranged from 0.17 to 14 standardised antibiotic days and patients who consumed antibiotic were categorised into two categories: ≤ 3 and > 3 standardised antibiotic days.…”

Antibiotic utilization pattern in burn patients admitted at tertiary hospital: A retrospective study

“…Studies have revealed that incorrect choice of antibiotics or its duration of action persists in 25% to 75% of cases [6]. It is very important to prescribe drug rationally especially in developing countries where the limited fund is available in health care and drugs [7].…”

“…An important aspect of antibiotic use is antibiotic consumption. There are several metrics of measuring antibiotic consumption [6]. One of the methods is developed and maintained by the WHO Collaborating Centre for Drug Statistics Methodology [9].…”

“…Thus, antibiotic resistance rates and higher healthcare costs resulting from drug-resistant infections can be lowered by reducing the consumption of unnecessary antibiotics. Studies have revealed that incorrect choice of antibiotics or its duration of action persists in 25% to 75% of cases [6]. It is very important to prescribe drug rationally especially in developing countries where the limited fund is available in health care and drugs [7].…”