Antibiotic consumption and resistance of gram-negative pathogens (collateral damage)

Čižman, Milan; Srovin, Tina Plankar

doi:10.3205/id000040

Cited by 19 publications

(8 citation statements)

References 53 publications

(68 reference statements)

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“…Antibiotic consumption may increase selective pressure on certain classes of antibiotics. Although antibiotic consumption in hospitals is much lower than in the community, the intensity of use ensures a high rate of antibiotic resistance in the hospitals (Cižman & Srovin, 2018). Previous studies used aggregated population-level data to investigate the correlation between antibiotic consumption and antibiotic resistance in P. aeruginosa, A.…”

Section: Antibiotic Resistancementioning

confidence: 99%

Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital

Sanjaya,

Siada,

Juanita

et al. 2024

Pharmaciana

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Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are the most critical groups of multi-drug resistant (MDR) bacteria that cause a threat in hospitals. This study identified the trend of antibiotic consumption, antibiotic resistance pattern, and the relationship between antibiotic consumption and antibiotic resistance in a critical group of bacteria in a general regional hospital. This ecological study was based on retrospective data from inpatient databases in a general regional hospital over three years (2017)(2018)(2019). The trend for annual antibiotic consumption over 2017-2019 was defined as defined daily doses/100 bed-days. The relationship between total antibiotic consumption and the percentage of antibiotic resistance among four isolated critical bacteria was explored in time series analysis and linear regression. The most frequently used antibiotic was ampicillin (220.33 DDD/100 bed-days), ciprofloxacin (126.86 DDD/100 bed-days), and ampicillinsulbactam (126.34 DDD/100 bed-days). There was a significant relationship between antibiotic consumption (ampicillin, ampicillin-sulbactam, ceftazidime, gentamicin, amikacin, and ciprofloxacin) in DDD/100 bed-days and antibiotic resistance in E. coli, K. pneumoniae, and P. aeruginosa (p<0.05) but not statically significant in A. baumannii (p=0.062). The annual usage fluctuated or remained stable, with no statistically significant trends change. The relationship between antibiotic consumption and antibiotic resistance was significant in three out of four critical groups of bacteria.

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Section: Antibiotic Resistancementioning

confidence: 99%

Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital

Sanjaya,

Siada,

Juanita

et al. 2024

Pharmaciana

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“…Despite these statistics, when the ratio between the consumption of broad-spectrum and narrow-spectrum antibiotics in the community is analyzed, it increased by 0.6% compared to 2013, with 5.6 DDD per 1000 inhabitants per day. These findings should be taken into consideration by the European authorities and the prescription plans revised so that their use can be reduced, since the use of broad-spectrum antibiotics is a factor in the development of resistance [ 136 ].…”

Section: One Health In Portugalmentioning

confidence: 99%

Tackling Carbapenem Resistance and the Imperative for One Health Strategies—Insights from the Portuguese Perspective

Mó,

da Silva

2024

Antibiotics

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Carbapenemases, a class of enzymes specialized in the hydrolysis of carbapenems, represent a significant threat to global public health. These enzymes are classified into different Ambler’s classes based on their active sites, categorized into classes A, D, and B. Among the most prevalent types are IMI/NMC-A, KPC, VIM, IMP, and OXA-48, commonly associated with pathogenic species such as Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The emergence and dissemination of carbapenemase-producing bacteria have raised substantial concerns due to their ability to infect humans and animals (both companion and food-producing) and their presence in environmental reservoirs. Adopting a holistic One Health approach, concerted efforts have been directed toward devising comprehensive strategies to mitigate the impact of antimicrobial resistance dissemination. This entails collaborative interventions, highlighting proactive measures by global organizations like the World Health Organization, the Center for Disease Control and Prevention, and the Food and Agriculture Organization. By synthesizing the evolving landscape of carbapenemase epidemiology in Portugal and tracing the trajectory from initial isolated cases to contemporary reports, this review highlights key factors driving antibiotic resistance, such as antimicrobial use and healthcare practices, and underscores the imperative for sustained vigilance, interdisciplinary collaboration, and innovative interventions to curb the escalating threat posed by antibiotic-resistant pathogens. Finally, it discusses potential alternatives and innovations aimed at tackling carbapenemase-mediated antibiotic resistance, including new therapies, enhanced surveillance, and public awareness campaigns.

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“…Particularly in IBD patients, the gut microbiota is already in an unstable state due to the disease condition ( Clooney et al, 2021 ; Kharaghani et al, 2023 ). Prolonged antibiotic use may further intensify imbalances in the community by increasing selective pressures for resistant strains ( Rashid et al, 2015 ; Cižman and Plankar, 2018 ), potentially exacerbating antibiotic resistance in IBD patients ( Park et al, 2014 ; Nitzan et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The impact of antibiotic exposure on antibiotic resistance gene dynamics in the gut microbiota of inflammatory bowel disease patients

Zhang,

Xue,

Wang

et al. 2024

Front. Microbiol.

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BackgroundWhile antibiotics are commonly used to treat inflammatory bowel disease (IBD), their widespread application can disturb the gut microbiota and foster the emergence and spread of antibiotic resistance. However, the dynamic changes to the human gut microbiota and direction of resistance gene transmission under antibiotic effects have not been clearly elucidated.MethodsBased on the Human Microbiome Project, a total of 90 fecal samples were collected from 30 IBD patients before, during and after antibiotic treatment. Through the analysis workflow of metagenomics, we described the dynamic process of changes in bacterial communities and resistance genes pre-treatment, during and post-treatment. We explored potential consistent relationships between gut microbiota and resistance genes, and established gene transmission networks among species before and after antibiotic use.ResultsExposure to antibiotics can induce alterations in the composition of the gut microbiota in IBD patients, particularly a reduction in probiotics, which gradually recovers to a new steady state after cessation of antibiotics. Network analyses revealed intra-phylum transfers of resistance genes, predominantly between taxonomically close organisms. Specific resistance genes showed increased prevalence and inter-species mobility after antibiotic cessation.ConclusionThis study demonstrates that antibiotics shape the gut resistome through selective enrichment and promotion of horizontal gene transfer. The findings provide insights into ecological processes governing resistance gene dynamics and dissemination upon antibiotic perturbation of the microbiota. Optimizing antibiotic usage may help limit unintended consequences like increased resistance in gut bacteria during IBD management.

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Antibiotic consumption and resistance of gram-negative pathogens (collateral damage)

Cited by 19 publications

References 53 publications

Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital

Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital

Tackling Carbapenem Resistance and the Imperative for One Health Strategies—Insights from the Portuguese Perspective

The impact of antibiotic exposure on antibiotic resistance gene dynamics in the gut microbiota of inflammatory bowel disease patients

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